Sheffield Teaching Hospitals Nhs Foundation Trust

This study tested whether mepolizumab, a drug already used for asthma, can help people with COPD who have frequent flare-ups and high levels of certain immune cells (eosinophils). Thirty-one participants took the drug for a year and had special MRI scans to measure lung inflammat…

This study tested two diet approaches for people with a common stomach condition called functional dyspepsia, where meals cause pain, fullness, or bloating. About 60 adults tried either standard tips (small meals, less caffeine and fatty foods) or a low FODMAP diet (avoiding cert…

This study tested whether lycopene, an antioxidant found in cooked tomatoes, can improve sperm quality in men with a low number of swimming sperm. 34 men took either lycopene capsules or placebo capsules for 12 weeks. Researchers compared semen samples before and after treatment …

This study looked at whether a telehealth system could help people with motor neurone disease (MND) receive specialist care from home. MND is a rare condition that causes muscle weakness and makes it hard to travel to clinics. The study involved 77 patients and their carers, with…

This study looked at how teriparatide, a bone-building drug, works in 19 postmenopausal women with osteoporosis. The goal was to understand the changes in bone density and turnover over two years. The findings could help researchers develop better treatments for osteoporosis in t…

This study looked at how different doses of aspirin affect the body's immune response. Healthy volunteers took various aspirin doses for 10-14 days, then received a substance that causes temporary flu-like symptoms to test their immune reaction. The goal was to see if a lower, tw…

This study looked at how doctors treat hernias that need emergency care. Researchers followed 280 adults to track complications, recovery time, and quality of life. The goal was to gather data to help improve treatment for this common but serious condition.

This study looked at whether taking a laxative (Polyethylene Glycol) before a capsule endoscopy helps doctors see the small intestine better. 230 adults were randomly assigned to take the laxative as a single dose, a split dose, or just clear liquids. The goal was to see which me…

This study looked at how being isolated during the COVID-19 pandemic affected the mental health of 232 people with inflammatory bowel disease (IBD). Researchers used questionnaires to measure anxiety, depression, and other psychological symptoms. The goal was to understand the em…

This study tested whether a special MRI scan can measure how two common drugs, metformin and ciclosporin, affect the liver's ability to process a contrast dye. Twelve healthy adults each had MRI scans before and after taking one of the drugs. The goal was to see if this imaging t…

This study looked at whether a very low dose of aspirin taken twice daily, combined with a blood thinner called rivaroxaban, works better than standard aspirin doses in people with chronic coronary syndromes. 48 adults already on daily aspirin were given different combinations of…