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Tomato pill may help men with low sperm count, early study suggests

NCT ID NCT05671562

Symptom relief Sponsor: Sheffield Teaching Hospitals NHS Foundation Trust Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This pilot study tested whether lycopene, an antioxidant found in cooked tomatoes, can improve sperm quality in men with low total motile sperm count. 34 men took either lycopene capsules or placebo for 12 weeks. Researchers measured changes in sperm count, movement, shape, and DNA health before and after treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
lycopene (an antioxidant found in cooked tomatoes)
What this could lead to
If it works, this could point toward a simple dietary supplement to improve sperm quality in men with low motile sperm count.
What could go wrong
This is a very small pilot study with only 34 participants. Results may not apply to all men, and the supplement may not work better than placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

34 people

The number who actually took part.

Started

May 2023

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 50 years

Sex

Male participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Males aged 18 - 50 years of age 2. Attending the Fertility Clinic at the Jessop Wing, (Sheffield Teaching Hospitals). 3. Found to have poor testicular function as evidenced by a low motile sperm count (\<20 million motile sperm per ejaculate). 4. Willing to comply with the study procedures and provide informed consent. Exclusion Criteria: 1. Participants who report allergy to tomatoes, whey, soy. 2. Men with previous testicular surgery or a current or previous diagnosis of cancer. 3. Men found to have normal sperm parameters. 4. Known infection with hepatitis or HIV. 5. Men with azoospermia

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Total motile sperm count

Contacts and locations

Locations

  • Jessop Fertility

    Sheffield, United Kingdom