Samsung Medical Center

This study is for men whose prostate cancer has come back after surgery, shown by rising PSA levels. It compares a standard few weeks of radiation to a much shorter course of just a few days. The goal is to see if the shorter option works just as well to control the cancer while …

This study tests whether a stronger blood thinner (prasugrel) combined with aspirin works better than the standard combination of clopidogrel and aspirin for people with coronary artery disease who need complex stents. About 3,500 adults will be randomly assigned to one of the tw…

This study looks at whether people with chronic heart disease and a high risk of bleeding can safely stop taking antiplatelet drugs (blood thinners) after a special balloon treatment called drug-coated balloon angioplasty. Participants must have been stable for at least a year af…

This study tests whether the drug osimertinib can stop or shrink small, hazy lung spots (called GGNs) that remain after surgery for a type of lung cancer. About 59 adults with EGFR-mutated lung cancer will take a daily pill for a period of time. The goal is to see if the drug pre…

This study tests a drug called patritumab deruxtecan in 30 adults with advanced solid tumors that have a rare NRG1 gene fusion. The drug targets a protein on cancer cells to stop their growth. The main goal is to see how many patients' tumors shrink or disappear.

This study compares two procedures for removing small precancerous growths (≤1 cm) in the stomach: argon plasma coagulation (APC), a simpler, non-contact method, and endoscopic mucosal resection (EMR), which cuts out the tissue. About 160 adults with low-grade dysplasia will be r…

This study tests whether giving the immunotherapy drug avelumab after standard chemotherapy can help prevent upper tract urothelial cancer from coming back. About 48 adults who have already completed chemotherapy and show no signs of cancer will receive avelumab as a maintenance …

This study tests whether a drug-coated balloon works better than a drug-eluting stent for treating complex blockages in heart arteries. About 520 adults with coronary artery disease will be randomly assigned to one of the two procedures. The main goal is to see which approach red…

This study tests whether the drug osimertinib can stop small, hazy spots (called GGNs) left in the lungs from growing after surgery for a type of lung cancer. It includes 43 adults with stage I lung cancer and a specific gene mutation. Participants take a daily pill for one year,…

This study compares a new AI-driven method (MPFFR) against the standard invasive FFR test to decide if and where to place stents in blocked heart arteries. About 2,100 adults with coronary artery disease will be randomly assigned to one of the two approaches. The goal is to see i…

This study looks at whether people who have had a heart attack but do not have heart failure can safely stop taking beta-blockers after at least one year. About 2,540 adults will be randomly assigned to either stop or continue the medication. The goal is to see if stopping is jus…

This study looks at whether starting treatment early for atrial fibrillation (AF) that is only detected by heart devices can reduce the amount of AF or prevent it from becoming a full-blown condition. About 520 adults with heart devices will be split into two groups: one gets ear…

This study tests a combination of two targeted drugs, lazertinib and tepotinib, in people with a specific type of advanced lung cancer (EGFR-mutant non-small cell lung cancer) that has stopped responding to lazertinib alone due to a change in the MET gene. About 47 participants w…

This study looks at two different places to put a pacemaker lead in people with sick sinus syndrome. The goal is to see which spot—Bachmann's bundle or the right atrial appendage—better protects the heart's upper chambers from damage. Researchers will track heart structure and fu…

This study tests whether a personalized form of brain stimulation (rTMS) can improve walking and movement in people with Parkinson's disease better than the standard one-size-fits-all approach. Researchers will tailor the stimulation target based on each patient's brain function.…

This study tests whether personalized brain stimulation (rTMS) can improve arm and hand movement in people who recently had a stroke. About 120 participants will receive either standard or customized stimulation based on their individual brain reserve. The goal is to see if a tai…

This study looks at whether chest CT scans can help predict how well lung cancer responds to chemoimmunotherapy given before surgery. Researchers will compare CT images taken before and after treatment with actual tumor tissue removed during surgery. The goal is to develop a noni…

This study is developing and testing a goal-setting strategy for children in the pediatric intensive care unit (PICU). Researchers will work with experts and families to create a tool that helps set meaningful goals based on what matters most to the child and their caregivers. Th…

This study follows 300 Korean adults with high-grade upper tract urothelial carcinoma to monitor for cancer recurrence after chemotherapy and surgery. Researchers collect blood samples and medical data over time to build a platform that may help predict when the cancer comes back…

This study screens up to 797 people with relapsed small cell lung cancer to identify genetic changes in their tumors. No experimental drugs are given; instead, researchers analyze tissue and blood samples to classify cancer subtypes. The goal is to prepare for future trials that …

This study is for adults with hemophagocytic lymphohistiocytosis (HLH), a rare condition where the immune system becomes overactive and damages the body. Researchers want to learn more about how the disease behaves in adults and how patients respond to standard treatments like st…

This study is collecting medical information and tissue samples from 350 adults with head and neck cancer at Samsung Medical Center. Researchers want to understand why some patients respond better to treatment than others. The goal is to find biological markers that can help doct…

This study looks at whether a special heart scan (coronary CT angiography) is better than standard follow-up care for high-risk patients who have had a stent placed to open blocked arteries. About 3,500 adults aged 19 and older with complex heart conditions will be enrolled. The …