National Cancer Institute, Naples

This study tests whether adding two common drugs—valproic acid and simvastatin—to standard chemotherapy can help people with advanced pancreatic cancer that has spread. About 240 adults who have not had prior treatment will be randomly assigned to receive chemo alone or chemo plu…

This study tests whether the drug regorafenib can help people with a specific type of advanced colorectal cancer (RAS-mutant) live longer without their cancer growing. About 60 adults whose cancer has spread and who have already received one prior treatment will take regorafenib.…

This study looks at how well the drug dostarlimab works and how safe it is for people with a certain type of advanced rectal cancer (dMMR/MSI-H). Researchers will track 50 patients who receive the drug before any other treatment, using real-world data from a national registry. Th…

This study tests whether adding simvastatin, a common cholesterol medication, to standard chemotherapy and immunotherapy can help people with a specific type of advanced stomach or esophageal cancer live longer without their disease getting worse. The trial is for 84 adults whose…

This study tests whether adding valproic acid (a drug used for seizures and mood disorders) to a standard anti-EGFR therapy can help people with advanced colorectal cancer whose cancer has returned after previous treatments. About 130 adults with a specific genetic type (RAS/BRAF…

This study is testing whether two drugs, pembrolizumab and lenvatinib, can shrink tumors in people with advanced vulvar cancer that cannot be removed by surgery. About 80 participants will receive the combination therapy. The main goals are to see how many patients respond to tre…

This study is watching how well a single-port robotic system (da Vinci SP) works for staging surgery in people with endometrial cancer. Researchers will track how often the surgery is completed successfully and how many complications occur. The goal is to see if this newer roboti…

This study looks at how the cost of cancer treatment affects the finances of people with early-stage breast cancer. Researchers will follow about 864 patients for one year, asking them to fill out surveys about their financial stress. The goal is to understand what causes financi…

This study looks at proteins called selenoproteins in people with a type of breast cancer (triple-negative) and in healthy women. Researchers want to see if these proteins can help predict how the disease will progress or be used as targets for future treatments. The study does n…

This study gathers information from 15,000 cancer patients to see how well the healthcare system works. It looks at how quickly patients get diagnosed, treated, and supported. No new drugs or treatments are given. The goal is to find ways to make cancer care faster and more effic…