National Cancer Institute, Naples

This study is tracking 50 people with a specific type of advanced rectal cancer (dMMR/MSI-H) who are getting the drug dostarlimab before surgery. The goal is to see how well the drug shrinks tumors and how safe it is in everyday medical practice, not just in a controlled research…

This study is testing whether two drugs, pembrolizumab and lenvatinib, can shrink tumors in people with advanced vulvar cancer that cannot be removed by surgery. About 80 participants will receive the combination therapy. The main goals are to see how many patients respond to tre…

This study tests whether the drug regorafenib can help people with a specific type of advanced colorectal cancer (RAS-mutant) who have already tried one treatment. The goal is to see if a less intensive approach can keep the cancer from growing for at least 6 months while maintai…

This study tests whether adding simvastatin, a common cholesterol medication, to standard chemotherapy and immunotherapy can help people with a specific genetic type of advanced stomach or esophagus cancer. About 84 adults whose cancer has a mutation in the ARID1A gene will recei…

This study is for people with a certain type of advanced colorectal cancer that has not responded well to previous treatments. Researchers want to see if adding valproic acid, a drug usually used for seizures, can make a standard cancer therapy work again. About 130 adults will b…

This study tests whether adding valproic acid and simvastatin to standard chemotherapy can help people with advanced pancreatic cancer that has spread. About 240 adults who have not had prior treatment will be randomly assigned to receive either the standard chemo or the standard…

This study gathers information from 15,000 cancer patients to see how well the healthcare system works. It looks at how quickly patients get diagnosed, treated, and supported. No new drugs or treatments are given. The goal is to find ways to make cancer care faster and more effic…

This study is observing how well a single-port robotic system (da Vinci SP) performs staging surgery for endometrial cancer. About 564 patients will be enrolled to track how often the surgery is completed successfully, as well as any complications during or after the procedure. T…

This study is looking at proteins called selenoproteins in people with a type of breast cancer called triple-negative breast cancer (TNBC). Researchers want to see if these proteins can help predict how the disease will progress or be used as targets for future treatments. The st…

This study looks at how the cost of cancer treatment affects the finances of people with early-stage breast cancer. Researchers will follow 864 patients for one year, using a questionnaire to measure changes in financial distress. The goal is to understand what causes financial p…