Could a $4 cholesterol pill help fight stomach cancer? new trial aims to find out.

NCT ID NCT07213557

Recruiting now Disease control Sponsor: National Cancer Institute, Naples Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 24, 2026 · Updated 33 times

Summary

This study tests whether adding simvastatin, a common cholesterol medication, to standard chemotherapy and immunotherapy can help people with a specific type of advanced stomach or esophageal cancer live longer without their disease getting worse. The trial is for 84 adults whose tumors have a mutation in the ARID1A gene and have not had prior treatment for advanced disease. Participants will be randomly assigned to receive either the standard treatment alone or the standard treatment plus simvastatin.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Istituto Nazionale Tumori Fondazione G. Pascale
RECRUITING

Naples, Italia, 80131, Italy

Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

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ADVANCED OR METASTATIC GASTROOESOPHAGEAL CARCINOMA