Mario Negri Institute For Pharmacological Research

This study is for people with stage III lung cancer whose tumor has come back in the chest after previous treatment with chemotherapy, radiation, and the drug durvalumab. Researchers want to see if giving radiation again followed by two drugs (durvalumab and ceralasertib) is safe…

This observational study follows 500 adults with primary membranous nephropathy and nephrotic syndrome who are treated with rituximab or similar antibody drugs. Researchers will track how well the disease responds over time and what factors predict better outcomes. The goal is to…

This study tests whether adding omega-3 fatty acids from fish or plant oils to the diet can reduce inflammation and improve heart health in people at moderate to high risk. About 324 adults over age 55 will take fish oil, camelina oil, or a regular diet for 12 weeks. Researchers …

This study tests whether breathing argon gas after a cardiac arrest can reduce brain damage. Researchers will give argon to 120 adults who have been resuscitated from a witnessed cardiac arrest with a shockable heart rhythm. The goal is to see if argon helps protect the brain and…

This study tests if a drug called patiromer can help people on dialysis safely eat more potassium-rich foods without dangerous side effects. About 40 adults on stable dialysis will receive either patiromer or a placebo. The goal is to see if the drug allows a less strict diet whi…

This study tests whether acetyl-L-carnitine (ALCAR), a natural substance, can slow the loss of function in people with ALS. About 246 adults with early-stage ALS will receive either a low or high dose of ALCAR or a placebo for 48 weeks, while continuing standard treatment. Resear…

This study looks at people with atypical hemolytic uremic syndrome (aHUS), a rare disease that damages red blood cells and kidneys. Researchers want to understand how certain rare gene mutations affect the disease and whether they can find drugs that fix these problems. Participa…

This study looks at how often brain CT scans are used for people with mild head injuries in Italian emergency rooms. Many of these scans show nothing wrong, so the goal is to understand why they are done and find ways to avoid unnecessary ones. The study will also check if curren…

This study looks at blood cells from 86 people with membranous nephropathy, a kidney disease, to find out why some get better with B-cell therapy and others don't. Researchers will compare immune cells in patients who respond to treatment, those who don't, and healthy volunteers.…

This study is testing new ultrasound techniques to get detailed images of blood vessels in the arm and neck. Researchers will examine 60 healthy adults to set normal ranges for vessel size, blood flow, and stiffness. The goal is to improve future research on kidney and brain dise…

This study involves 39,000 patients in semi-intensive care units to continuously evaluate and improve healthcare quality. Researchers will track patient outcomes like transfers to intensive care or death. No new treatments are tested; the goal is to understand and enhance care pr…

This study aims to create a computer tool that can read and understand emergency department medical records. Researchers will check if the tool can accurately pull out key information from the records of 300,000 adult patients. The goal is to make it easier to use real-world data…

This study checks how consistent kidney MRI measurements are when using 1.5T scanners. About 48 healthy adults aged 18-70 will undergo scans to measure kidney size, blood flow, and oxygen levels. The goal is to improve the reliability of MRI for future kidney disease diagnosis an…

This study looks at whether the sound made by blood flowing through an arteriovenous fistula (AVF) can tell doctors about its condition. Researchers will measure sound patterns and compare them to blood flow disturbances in 15 adults with end-stage kidney disease who need a new A…

This study looks at why some emergency departments (EDs) in Europe admit more patients than others, even for similar symptoms like breathing trouble or fainting. Researchers will analyze data from 162,000 adults who visited an ED between 2021 and 2023. The goal is to create a fai…

This study is testing a new method called RNA-Seq to find genetic causes of rare diseases in people who have not been diagnosed with standard genetic tests. Researchers will take skin samples from about 105 participants, including healthy volunteers and patients with known or sus…

This study looks at blood samples from 100 adults with a kidney condition called idiopathic nephrotic syndrome. Researchers want to measure levels of certain autoantibodies (anti-nephrin) to see if they are linked to the disease. The goal is to better understand the disease, not …