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Could argon gas help comatose cardiac arrest patients?

NCT ID NCT05482945

Disease control Sponsor: Mario Negri Institute for Pharmacological Research Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This phase 2 trial tests whether breathing a mix of argon gas and oxygen soon after a cardiac arrest can reduce brain damage. Researchers will enroll 120 comatose patients who were resuscitated from a witnessed cardiac arrest. The main goal is to see if argon lowers a brain injury marker in the blood, with additional checks on heart damage, brain scans, and survival.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Argon gas (mixed with oxygen)
What this could lead to
If it works, this could point toward a simple, safe way to protect the brain and heart after cardiac arrest, improving recovery and survival.
What could go wrong
This is a mid-stage trial with only 120 patients. Argon's benefits seen in animals may not translate to humans, and the primary outcome is a biomarker, not long-term function.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 120 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2022

Expected to finish

Jun 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * ICU admission after resuscitation from witnessed non-traumatic out-of-hospital cardiac arrest (OHCA) of presumably cardiac etiology with a presenting shockable rhythm; * age ≥ 18 years; * unconsciousness after return of spontaneous circulation (ROSC); * duration of CPR ≤ 40 mins; * initiation of study intervention ≤ 4 hrs from ROSC; * stable SaO2 ≥ 94% with a FiO2 of 30%. Exclusion Criteria: * Non-witnessed CA; * CA of traumatic origin or from a non-presumably cardiac cause; * CA with a non-shockable presenting rhythm (pulseless electrical activity and asystole); * female of childbearing potential defined as younger of 50 years; * pregnancy; * known terminal illness; * pre-CA cerebral performance category (CPC) ≥ 3; * initiation of the study intervention \> 4 hrs from ROSC; * participation to another clinical trial

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Conditions

The condition(s) this trial relates to.

cardiac arrest Out-of-Hospital Cardiac Arrest

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiac arrest with successful resuscitation Cardiac arrest, out-of-hospital

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    9 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Arcispedale Santa Maria Nuova di Reggio Emilia

    NOT_YET_RECRUITING

    Reggio Emilia, Reggio Emilia, 42123, Italy

  • Azienda Ospedaliero - Universitaria di Parma

    NOT_YET_RECRUITING

    Parma, Parma, 43126, Italy

  • Azienda Sanitaria Universitaria Giuliano Isontina (Asugi) di Trieste

    RECRUITING

    Trieste, TS, 34148, Italy

  • Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

    RECRUITING

    Milan, Milan, 20122, Italy

  • Fondazione Policlinico Universitario Agostino Gemelli IRCCS

    RECRUITING

    Roma, RM, 00168, Italy

  • Ospedale Civile Santa Maria degli Angeli di Pordenone

    RECRUITING

    Pordenone, Pordenone, 33170, Italy

  • Ospedale Policlinico San Martino di Genova

    RECRUITING

    Genova, GE, 16132, Italy

  • Ospedale San Gerado

    RECRUITING

    Monza, MB, 20900, Italy

  • Ospedale Santa Chiara di Trento

    RECRUITING

    Trento, Trento, 38122, Italy

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