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Breath of life: CO2 readings may predict cardiac arrest survival

NCT ID NCT07632430

Knowledge-focused Sponsor: Office of the Medical Director for EMS in Oklahoma City and Tulsa Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether the amount of carbon dioxide a person breathes out during CPR can help predict if they will survive a cardiac arrest that happens outside a hospital. Researchers are reviewing records from 3,500 adults who had a cardiac arrest and were treated by emergency services. The goal is to find which CO2 patterns are most strongly linked to survival and good brain function after discharge.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help paramedics better predict which patients might survive cardiac arrest, guiding more informed treatment decisions.
What could go wrong
This is an observational study, not a treatment trial. It may not find a clear link between CO2 levels and survival, and results may not apply to all settings.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 3,500 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2024

Expected to finish

Sep 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

This is a retrospective cohort study. All patients encountered by emergency medical services in Oklahoma City and Tulsa experiencing an out-of-hospital cardiac arrest from Jan 1, 2024, to July 1, 2025, will be evaluated against the inclusion and exclusion criteria.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria * EHR's resulting from 9-1-1 response * Adult patients (aged 18+ at time of cardiac event) * experiencing out-of-hospital cardiac arrest (OHCA) * transported by an agency under OMD oversight * must have at least 2 EtCO2 values captured during care Exclusion Criteria * EHR's resulting from inter-facility scheduled or unscheduled medical transfers * pediatric patients (those aged \<18 at time of incident) or unknown age * ROSC obtained prior to arrival of EMS * insufficient vital sign data

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Conditions

The condition(s) this trial relates to.

cardiac arrest Out-of-Hospital Cardiac Arrest

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiac arrest, out-of-hospital End tidal carbon dioxide Prehospital emergency medical services Prehospital resuscitation

Contacts and locations

Locations

  • Office of the Medical Director of EMS for Metropolitan Oklahoma City and Tulsa

    Oklahoma City, Oklahoma, 73135, United States

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