Mario Negri Institute For Pharmacological Research

This study looks at 75 kidney transplant patients to compare two different anti-rejection drug plans. One group gets a single dose of a drug called RATG, while the other gets seven doses over a week. Both groups also receive other standard medications. The goal is to see which pl…

This study looks at whether adding olaparib to standard bevacizumab maintenance therapy helps women with a specific type of advanced ovarian cancer (HRD-positive) stay cancer-free longer after initial chemotherapy. About 190 participants who have already responded to first-line t…

This study reviews medical records from 70 adults with advanced polycystic kidney disease (ADPKD) who are already taking the drug octreotide LAR. The goal is to find out which early signs, like total kidney volume, best predict how fast kidney function will drop over time. No new…

This study gathers medical images (like MRI and CT scans) from 300 adults—some healthy, some with kidney or brain disease—to create a research library. The images and related health data will be stored and shared with other scientists for not-for-profit studies. No new treatments…

This study tests a new indicator called Fenice that measures how crowded an emergency room is. Researchers want to see if it matches what healthcare workers feel about crowding levels. The study involves 828 patients across multiple hospitals. It aims to improve how we understand…

This study looks at 50 people with nephrotic syndrome to see if a newer blood test (cystatin C) is better than the standard creatinine test at measuring kidney function. Researchers will compare both estimates to a direct measurement of kidney filtration. The goal is to find the …

This study aims to create a computer program that can check whether patients admitted to the emergency room actually needed to be there. Researchers will look at data from 1,200 adults who came in with chest pain, belly pain, trouble breathing, or fainting. The goal is to improve…

This study explores whether artificial intelligence can create realistic, privacy-protected health data from real patient records of autosomal dominant polycystic kidney disease (ADPKD). Researchers will use these simulated datasets to run virtual clinical trials and check if the…

This study aims to develop better lab tests to diagnose and monitor two rare kidney diseases: aHUS and C3G. Researchers will analyze blood, cells, and kidney tissue from 180 patients and healthy volunteers. The goal is to find markers that help doctors choose the right treatment …