Mario Negri Institute For Pharmacological Research

This study tests a new approach for women with a common type of early breast cancer (HR+/HER2-). Instead of standard chemotherapy before surgery, some participants will receive a targeted drug (abemaciclib) plus hormone therapy, based on a gene test result. The goal is to see if …

This study tests a drug called obinutuzumab in 10 adults with a kidney condition called nephrotic syndrome that keeps coming back despite standard treatments. The goal is to see if a single course can keep the disease in remission for at least 12 months without needing repeated r…

This study will test a new wearable device that records sounds from the blood vessel connection used for dialysis. Six adults on hemodialysis will wear the device once a week for 8 weeks. The goal is to see if the device can accurately measure blood flow sounds compared to a stan…

This study looks at stored blood and kidney samples from 120 people with membranous nephropathy (a kidney disease) and healthy volunteers. Researchers want to find genetic and protein markers that can predict which patients will respond well to the drug rituximab. The goal is to …

This study aims to understand how SGLT2i medications protect the kidneys in people with diabetic kidney disease who are at risk of worsening. Researchers will use special MRI scans and blood tests to measure kidney function, blood flow, and other markers. The study involves 100 a…