Federico Ii University

This trial tests whether applying hyaluronic acid gel to exposed tooth roots during gum surgery improves healing compared with surgery alone. Researchers plan to enroll 80 adults with periodontitis who have suprabony defects, meaning bone loss that leaves pockets at least 5 mm de…

This trial tests whether a spermidine-based gel can improve the treatment of peri-implant mucositis, a condition where the gums around a dental implant become inflamed. Researchers will compare standard non-surgical cleaning alone against cleaning plus the gel in 20 adults with a…

Researchers are testing whether Lactobacillus GG, a probiotic, can help children with cow's milk allergy develop tolerance to milk. The study involves 20 children aged 4 months to 4 years. The goal is to see if the probiotic changes how genes related to the immune system are turn…

This trial tests whether the probiotic Lactobacillus rhamnosus GG can ease atopic dermatitis, a chronic skin condition causing dry, itchy patches, in children aged 6 to 36 months. Half of the 100 participants receive the probiotic daily, while the other half get a placebo. Resear…

This trial tests whether a nasal spray containing two probiotic bacteria strains can reduce allergy symptoms in children aged 6 to 12 with allergic rhinoconjunctivitis, a condition that causes sneezing, a runny nose, and itchy eyes. Researchers will compare the probiotic spray ag…

This study tested whether eating probiotic-enriched pasta daily for 4 weeks could improve metabolic health and reduce inflammation in overweight and obese adults. Forty healthy men and women with a BMI between 25 and 35 ate either probiotic pasta or regular pasta. Researchers mea…

This study looked at whether faricimab injections can help people with diabetic retinopathy, a diabetes-related eye disease. Over 12 months, 60 patients received the treatment and doctors measured changes in the back of the eye. The goal was to see if the drug could reduce abnorm…

This study tested a dietary supplement containing immune-supporting nutrients and postbiotics in 40 children aged 5–12 with asthma and/or allergic rhinitis. The goal was to see if the supplement could improve symptom control over 6 months. Researchers also looked at changes in im…

This study tested whether adding two special gels to standard cleaning helps treat gum inflammation around dental implants. 92 adults with at least one inflamed implant received either standard cleaning alone or cleaning plus the gels. The gels aim to reduce bleeding and plaque. …

This study tested a new supplement in 30 children with food allergies who were already avoiding certain foods. The goal was to see if the supplement could improve their growth, vitamin D and DHA levels, and immune system balance. The supplement is not a cure but aims to help chil…

This study tested whether taking sodium butyrate tablets for 12 weeks, along with a modestly reduced-calorie diet, helps overweight or obese adults (with or without type 2 diabetes) lose more weight and improve blood sugar and fat levels compared to a placebo. 46 participants wer…

Researchers are testing whether a handheld device that shines a special light on the inside of the mouth can help clinicians spot suspicious areas that might be precancerous or cancerous. The study will have three dentists with different levels of experience examine 200 adults, i…

This study is testing whether following a Mediterranean diet during pregnancy can reduce the chance of children developing allergies by age 2. Researchers are enrolling 276 healthy pregnant women (ages 20-35) who are at risk of having a baby with allergies. Participants receive p…

This study tests whether personalized nutritional counseling from a team of pediatricians, allergists, and dietitians can improve the quality of life for mothers of children with food allergies. Researchers will compare mothers already receiving this multidisciplinary care with t…

Many children with autism are picky eaters, often refusing fruits, vegetables, and proteins, which can lead to poor nutrition and obesity. This trial tests whether nutritional counseling focused on the Mediterranean diet can help these children become less selective and adopt hea…

This study tests whether a common probiotic (Lactobacillus rhamnosus GG) can reduce stomach issues like constipation and diarrhea in children with autism spectrum disorder. About 50 children aged 4 to 12 with both autism and ongoing stomach problems will receive the probiotic or …

This study tested a cream made from shiitake mushroom extract (SMosE) to see if it could improve skin barrier function, reduce oiliness, and soothe acne-prone skin. Researchers studied the extract in the lab and on human skin samples, then tested the cream on 40 adults with acne-…

This study tested a special cream containing a butyrate releaser (a substance that helps the skin barrier) in 100 children aged 6-36 months with eczema. The cream was compared to a standard moisturizer over 12 weeks. The goal was to see if it could reduce eczema severity and impr…

Researchers are testing whether compounds from ultra-processed foods, like additives and advanced glycation end-products (AGEs), can be found in breast milk. They will measure AGE levels in milk samples from 300 healthy nursing mothers and track their diets with a 7-day food diar…

Researchers are studying the gut bacteria of infants with cow milk allergy compared to healthy infants. They aim to see if differences in the types and functions of gut microbes are linked to food allergy. The study includes 600 children aged 6 to 12 months and also compares chil…

Researchers are investigating whether eating ultra-processed foods is linked to obesity and metabolic syndrome in children and teens. The study will compare three groups: children with obesity, children with obesity plus metabolic syndrome, and healthy controls. Participants will…

This study looks at breast milk in detail, analyzing its nutrients, microbes, and other components at different times of the day and during feedings. Researchers will collect milk samples from 100 Italian women who exclusively breastfeed their healthy, full-term babies. They will…

This study aims to identify biological markers of malnutrition by analyzing blood, saliva, and stool samples from 2,000 people, including those with malnutrition and healthy controls. Researchers will use advanced techniques to examine genetic, microbial, and metabolic profiles. …

This study investigates whether compounds found in ultra-processed foods, like advanced glycation end products (AGEs), might play a role in childhood eczema, also known as atopic dermatitis. Researchers will compare the diets of 100 children aged 6 months to 10 years, half with e…

This study measured how often adults with inflammatory bowel disease (Crohn's disease or ulcerative colitis) show signs of eating disorders, including avoidant/restrictive food intake disorder (ARFID). Researchers used questionnaires to assess eating habits and nutritional status…

This study looked at 90 children with cow's milk allergy to see if a special formula (Nutramigen LGG) changes how genes work. Researchers measured DNA changes over 12 months. The goal was to understand how the formula helps kids outgrow the allergy, not to test a new treatment.

This study examined 69 children aged 6 to 14 to see if a deviated nasal septum (a crooked wall inside the nose) is linked to allergic rhinitis (hay fever). Researchers compared kids with and without the deviation using allergy tests, nasal samples, and quality-of-life questionnai…

This study tested whether a computer technique called radiomics can help analyze eye scans from people with vitelliform lesions, which are yellow deposits under the retina that can change over time. Researchers looked at 50 participants' OCT images to see if radiomics could disti…