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Mushroom magic? shiitake extract cream shows promise for oily, Acne-Prone skin

NCT ID NCT06338046

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a cream made from shiitake mushroom extract (SMosE) to see if it could improve skin barrier function, reduce oiliness, and soothe acne-prone skin. Researchers studied the extract in the lab and on human skin samples, then tested the cream on 40 adults with acne-prone or scarred skin. The trial was double-blind and placebo-controlled, meaning neither the participants nor the researchers knew who got the real cream.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Shiitake mushroom oil-soluble extract (SMosE) in a topical cream
What this could lead to
If it works, this could point toward a natural ingredient for managing oily, acne-prone skin and improving skin hydration.
What could go wrong
This is a small, completed early-stage trial with only 40 participants. Results may not apply to everyone, and the extract is tested as a cosmetic, not a medicine.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

40 people

The number who actually took part.

Started

Oct 2023

Finished

Dec 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

25 to 40 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Subjects scheduled for eligibility screening at the study site * Female or Male sex * Subjects with acne prone skin or skin with scar from acne * Subjects exposed to sunlight for at least 4 hours a day * Signing the informed consent form written by the investigators * Certifying not taking part in another clinical study that could interfere with the current one * Affirming the truth of the personal information declared to the technical staff * Capable of following directions and reliable to respect the constraints of the protocol * Free to ensure the visits to the Research Lab * Subjects with self-perceived * Subjects may have mild to sensitive and stressed skin Exclusion Criteria: * Female subjects who are pregnant, breastfeeding, or planning a pregnancy * Subjects with severe overall photodamage as determined by the Investigator. * Subjects who have any dermatological disorder, which in the investigator's opinion, may interfere with the accurate evaluation of the subject's skin, including rosacea, acne, and excessively oily or dry skin. * Subjects who have demonstrated a previous hypersensitivity reaction to any of the ingredients of the study products. * Subjects' use of any medications that are known to potentially cause changes in the facial skin as determined by the Investigator. * Subjects who spend excessive time out in the sun. * Subjects who are unwilling or unable to comply with the requirements of the protocol. * Subjects deprived of freedom by administrative or legal decision or under guardianship * Subjects planning hospitalization during the study * Subjectsaving received vaccination within 2 weeks before the study or intending to be vaccinated during the study * Subjects with diseases in the period immediately preceding the current study under treatment topically or systemically with any drug that may affect the outcome of the test, particularly: systemic retinoids within 6 months, topical retinoids within 2 months anti-inflammatory or antihistamine products within the 2 weeks antibiotics within 2 weeks medication for malignancy (of any kind) within 5 years desensitization treatment within 6 months * Subjects in treatments with topical products based on alpha and beta-hydroxy acids in the 45 days before the start of the study * Subjects reactive to sun/having photosensitivity.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • RD Cosmetics Lab - Pharmacy Department, University of Naples Federico II

    Naples, 80131, Italy

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