Mushroom magic? shiitake extract cream shows promise for oily, Acne-Prone skin
NCT ID NCT06338046
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested a cream made from shiitake mushroom extract (SMosE) to see if it could improve skin barrier function, reduce oiliness, and soothe acne-prone skin. Researchers studied the extract in the lab and on human skin samples, then tested the cream on 40 adults with acne-prone or scarred skin. The trial was double-blind and placebo-controlled, meaning neither the participants nor the researchers knew who got the real cream.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Shiitake mushroom oil-soluble extract (SMosE) in a topical cream
What this could lead to
If it works, this could point toward a natural ingredient for managing oily, acne-prone skin and improving skin hydration.
What could go wrong
This is a small, completed early-stage trial with only 40 participants. Results may not apply to everyone, and the extract is tested as a cosmetic, not a medicine.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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RD Cosmetics Lab - Pharmacy Department, University of Naples Federico II
Naples, 80131, Italy