Mushroom magic? shiitake extract cream shows promise for oily, Acne-Prone skin

NCT ID NCT06338046

Completed Symptom relief Sponsor: Federico II University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a cream made from shiitake mushroom extract (SMosE) to see if it could improve skin barrier function, reduce oiliness, and soothe acne-prone skin. Researchers studied the extract in the lab and on human skin samples, then tested the cream on 40 adults with acne-prone or scarred skin. The trial was double-blind and placebo-controlled, meaning neither the participants nor the researchers knew who got the real cream.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Shiitake mushroom oil-soluble extract (SMosE) in a topical cream
What this could lead to: If it works, this could point toward a natural ingredient for managing oily, acne-prone skin and improving skin hydration.
What could go wrong: This is a small, completed early-stage trial with only 40 participants. Results may not apply to everyone, and the extract is tested as a cosmetic, not a medicine.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACNE SCARS SEBUM PRODUCTION SKIN BARRIER TO WATER LOSS

Contacts and locations

Locations

RD Cosmetics Lab - Pharmacy Department, University of Naples Federico II

Naples, 80131, Italy

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