Erasmus Medical Center

This early-stage trial tests a therapeutic vaccine called ISA104 in 24 people with chronic hepatitis B who are already on antiviral drugs. The goal is to see if the vaccine is safe and can boost the immune system to better fight the virus. Participants will receive either ISA104 …

Researchers compare two strengths of atropine eye drops, 0.05% and 0.5%, in Dutch children aged 6 to 11 with progressive nearsightedness. About 550 children use the drops for three years, then researchers follow them for two more years. The goal is to see which strength better sl…

This study tests a new device called the VariPulse catheter, which uses short electrical pulses to treat atrial fibrillation (AF), a common heart rhythm problem. Twenty adults with AF will get this treatment, and after 2-3 months, doctors will check if the treated veins are still…

This trial tests whether adding weekly thermotherapy, a treatment that heats the tumor and lymph nodes, to standard radiotherapy can help people with head and neck cancer who cannot receive chemotherapy. The goal is to find a safe dose of thermotherapy that does not cause severe …

This study tests whether taking potassium supplements can slow down kidney function loss in people with moderate-to-severe chronic kidney disease (CKD) and high blood pressure. About 532 adults with CKD stage 3b or 4 will receive potassium or a placebo. The goal is to see if pota…

This trial tests whether a personalized training program called 'Kleuter Extra' can improve executive functioning—skills like attention, self-control, and planning—in preschoolers aged 4 to 6 who have severe congenital heart disease. Many children with this condition face thinkin…

This trial investigates whether adding secretin—a hormone that helps produce bicarbonate—during machine perfusion of donor livers can restore the protective 'bicarbonate umbrella' in bile ducts. Researchers will treat up to 20 donor livers with secretin while they are kept on a m…

This study tests whether giving chemotherapy both before and after surgery helps people with pancreatic cancer live longer compared to chemotherapy only after surgery. About 378 patients with resectable pancreatic cancer will be randomly assigned to one of two treatment schedules…

This study evaluates 12 different healthy lifestyle programs for children aged 4 to 12 who are overweight. About 1,000 kids and their parents will take part in activities like sports, nutrition advice, and behavior coaching. Researchers will measure changes in quality of life, BM…

This study tests whether giving a special nutrient mixture (Olimel N12) during hemodialysis can help prevent muscle loss and improve quality of life in people with end-stage kidney disease. About 166 patients will receive either the nutrient infusion or a simple glucose solution …

This study looks at whether taking a daily multivitamin can prevent vitamin and mineral deficiencies in people using GLP-1 drugs (like tirzepatide) for weight loss. About 246 adults with obesity who have been on a stable GLP-1 dose for at least 3 months will be randomly assigned …

This study tests whether waiting to clamp the umbilical cord until after the baby's lungs have filled with air can reduce dangerous lung blood pressure (pulmonary hypertension) in newborns with congenital diaphragmatic hernia (CDH). About 140 infants with left-sided CDH will be r…

This study tests whether showing older adults a short educational video after a bicycle or scooter accident makes them more likely to wear a helmet in the future. Participants are aged 60 and older who came to the emergency department without a helmet. Half will watch the video, …

This study tests a computer dashboard that helps doctors and nurses in the Neonatal Intensive Care Unit (NICU) manage pain in newborn babies. The dashboard shows real-time data to flag when a baby may be in discomfort. Researchers will compare pain levels in 1,250 babies before a…

This study surveys senior digital-health leaders at 350 top-ranked smart hospitals worldwide to assess how they govern artificial intelligence. The goal is to understand current AI governance maturity and frameworks, then build a toolkit that helps other hospitals adopt AI respon…

This study follows 90 living liver donors to see how much their liver regrows within a year after donation. Researchers will use CT or MRI scans to measure liver volume and look for factors like age, sex, and weight that might influence regrowth. The goal is to better understand …

This study looks at whether a special MRI scan (MRCP) can accurately measure liver fat in people who want to donate part of their liver. Currently, donors need a liver biopsy, which is invasive and carries risks. The researchers will compare MRCP results with biopsy results from …