Central Hospital, Nancy, France

This study tests whether a drug called oxybutynin, given directly into the bladder, can improve bladder function in children with spina bifida who have not responded well to oral medication. The goal is to increase bladder capacity and reduce the need for more invasive treatments…

This study tests whether adding a contrast dye to standard ultrasound can more accurately diagnose ovarian torsion (twisted ovary) and reduce unnecessary emergency surgeries. About 256 women with suspected torsion will be randomly assigned to standard ultrasound or contrast-enhan…

This study aims to see if a computer algorithm called BodySleep can accurately diagnose obstructive sleep apnea in children using fewer sensors than the standard hospital sleep test. The standard test (polysomnography) requires many wires and is hard for kids to tolerate. If Body…

This study tests a special microscope (CLE) that lets doctors see lung tissue in real time during a biopsy. The goal is to quickly tell if a suspicious spot is non-small cell lung cancer and what type it is. About 70 adults getting a standard lung biopsy will also have CLE imagin…

This study compares the latest 2024 McDonald criteria with the 2017 version for diagnosing multiple sclerosis (MS) in everyday medical practice. Researchers will enroll 100 people with symptoms suggestive of MS and track them for two years. The goal is to see if the new criteria …

This study tests whether regularly monitoring symptoms in dialysis patients and automatically notifying their care teams can improve quality of life. About 2,293 adults with end-stage kidney disease will participate across French dialysis centers. The goal is to help doctors addr…

This study aims to improve MRI scans by testing new ways to take images. The goal is to get clearer pictures while making the exam more comfortable for patients. Researchers will compare the new methods to standard ones in 720 healthy adults and people already scheduled for an MR…

This study looks at why the area destroyed by microwave ablation for liver tumors often differs from what doctors expect. Researchers will review medical records of 90 adults to see how factors like liver health, tumor location, and prior treatments affect the final ablation size…

This study looks at how the drug dapagliflozin affects the heart and kidneys in 103 adults with advanced heart failure who are waiting for a heart transplant. Researchers will measure a protein called suPAR in the blood to track changes in kidney health over 6 months. The goal is…

This study aims to better understand how blood flows in the placenta during pregnancies affected by fetal growth restriction. Researchers will use a special contrast dye during ultrasound to separately view blood flow on the mother's and baby's sides of the placenta. The study in…

This study is creating a large database of people with infective endocarditis, a serious heart infection. Researchers will collect information from 5,000 participants across France to understand the disease, its risk factors, and how it is treated. The goal is to improve future c…

This study looks at why some critically ill patients develop severe fungal infections after abdominal surgery while others do not. Researchers will measure a specific immune marker (HLA-DR) in 100 ICU patients to compare immune function between those with fungal versus bacterial …

This study looks at how the antifungal drug rezafungin spreads into the abdominal cavity of critically ill patients with a serious fungal infection after abdominal surgery. Researchers will measure drug levels in the blood and in fluid from the abdomen to see if enough reaches th…

This study is testing a new decision-making tool to help nurses place IV lines more successfully on the first try, especially in people with difficult veins. About 800 adults who need an IV will take part, and researchers will track how many needle sticks are needed. The goal is …

This study looks at the gut microbiome (bacteria, fungi, and viruses) in people with Crohn's disease, with or without arthritis, and compares them to healthy volunteers. The goal is to find biological markers that could help understand the link between these conditions. No treatm…