Canadian Cancer Trials Group

This study looks at whether taking a break from standard immunotherapy (a PD-1 inhibitor) works as well as taking it continuously for people with advanced melanoma that cannot be removed by surgery. About 614 participants will be randomly assigned to either intermittent or contin…

This study is for people with a type of advanced breast cancer (ER+/HER2-) that has stopped responding to standard pills. Researchers want to see if testing a blood sample for genetic markers can help match patients to treatments that work better for them. About 484 participants …

This study tests whether a combination of two newer drugs (pembrolizumab and brentuximab vedotin) can shrink or eliminate Hodgkin lymphoma that has returned or not responded to initial treatment. About 84 adults will be randomly assigned to receive either this new combo or standa…

This study compares two radiation approaches for people with 5 to 15 brain metastases: stereotactic radiosurgery (SRS), which targets only the tumors, versus whole-brain radiation that avoids the memory center (HA-WBRT) plus a drug called memantine to protect thinking skills. Abo…

This study tests whether adding the drug ibrutinib to standard chemotherapy can stop primary central nervous system lymphoma from growing or spreading. It is for 30 adults aged 18 or older who are newly diagnosed and cannot have a stem cell transplant due to age or health issues.…

This study is for older adults with newly diagnosed multiple myeloma who cannot have a stem cell transplant. It compares taking the drug daratumumab or isatuximab continuously versus stopping after about 18 months. The goal is to see if the shorter treatment works just as well in…

This study is for people with early-stage endometrial cancer who have specific genetic markers (POLE-mutated or p53wt/NSMP). It tests whether using less intense treatment after surgery can still keep the cancer from coming back. About 393 participants will receive tailored therap…

This study is for people with prostate cancer that has spread and is not responding as expected to standard hormone therapy. Researchers want to see if adding a chemotherapy drug called docetaxel to the usual treatment can lower the chance of the cancer growing or spreading. Abou…

This study tests whether giving chemotherapy alone before limited surgery works as well as chemotherapy plus radiation for early-stage rectal cancer. The goal is to see if avoiding radiation can improve patients' quality of life without harming cancer control. About 250 adults wi…

This study tests whether adding targeted radiotherapy to usual drug treatments can slow the growth or spread of lung cancer in people with metastatic non-small-cell lung cancer. About 320 participants whose cancer has started to grow in a limited number of spots while on first-li…

This study compares a three-drug combination (durvalumab, tremelimumab, and lenvatinib) against a two-drug combo (durvalumab and tremelimumab) in people with advanced liver cancer that cannot be removed by surgery. About 140 adults who have not had prior cancer treatment will par…

This study looks at whether a simple blood test can help doctors decide when to add chemotherapy to standard immunotherapy for lung cancer. The blood test measures tiny bits of tumor DNA (ctDNA) that cancers release. About 230 people with advanced lung cancer will take part, and …

This study is for people with aggressive B-cell lymphoma that has come back or not responded to treatment. Researchers are testing a new drug added to standard chemotherapy to find the highest dose that is safe and tolerable. The goal is to control the disease and improve outcome…

This study looks at whether women with a low-risk type of breast cancer can safely skip regional radiation therapy after standard treatment. About 2,140 participants will be randomly assigned to receive either usual care with radiation or no radiation to the lymph nodes and chest…

This study tests whether a newer, more precise type of radiation (SBRT) provides better pain relief than standard radiation for people with cancer that has spread to bones other than the spine. About 230 adults with solid tumors and painful bone metastases will receive either SBR…

This study looks at whether the type of early-stage vulvar cancer (based on HPV and p53 status) needs more or less surgery than usual. About 249 adults with stage I-II vulvar squamous cell carcinoma will have their surgery guided by these markers. The goal is to see if this perso…

This study looks at whether starting treatment early or waiting is more cost-effective for people with high-risk chronic lymphocytic leukemia (CLL) who have no symptoms. Researchers will track medical costs and quality of life for up to 10 years in about 247 Canadian patients. Th…