Canadian Cancer Trials Group

This study tested whether a 3-year physical activity program could help prevent colon cancer from returning in people who had surgery and chemotherapy for high-risk stage II or stage III colon cancer. About 889 participants were randomly assigned to either the exercise program pl…

This early-phase study tested a new combination of drugs (romidepsin, gemcitabine, dexamethasone, and cisplatin) in 21 people with peripheral T-cell or diffuse large B-cell lymphoma who had already tried other treatments. The main goal was to find the safest dose and understand s…

This study tested a new drug called RP-6306 in 28 people with advanced cancer that could not be cured. The goal was to see if adding RP-6306 to standard treatment helps shrink tumors and is safe. Researchers also looked for specific biomarkers to see if some patients respond bett…

This study tested giving chemotherapy before a less invasive surgery for early rectal cancer. The goal was to see if this approach could allow patients to keep their rectum instead of needing major surgery. 58 people took part, and the treatment was considered successful if at le…

This study tested two different dosing schedules of the drug palbociclib combined with hormone therapy in 180 women with advanced, hormone-receptor-positive breast cancer. The goal was to see if a lower daily dose (100 mg) works as well as the standard higher dose (125 mg) but wi…

This study compared two types of radiation therapy for men with intermediate-risk prostate cancer: standard image-guided external beam radiation (IGRT) versus IGRT plus a high-dose-rate brachytherapy boost. The goal was to see which treatment works better and what side effects oc…

This phase 3 trial tested whether a biologic called IMM-101 could reduce severe respiratory infections, including COVID-19, in cancer patients at higher risk. 195 participants either received three doses of IMM-101 or were simply observed. The goal was to see if the treatment cou…