UVEAL MELANOMA

This phase 3 trial tests a new treatment called belzupacap sarotalocan (AU-011) for people with early-stage eye cancer (small choroidal melanoma) or suspicious spots. The drug is injected into the eye and then activated by a laser. The goal is to stop the tumor from growing while…

This Phase 3 trial tests darovasertib, an oral drug, given before standard local therapy (radiation or surgery) for people with primary uveal melanoma that hasn't spread. The goal is to see if the drug can reduce vision loss and help save the eye from removal. About 520 participa…

This pilot trial is testing a personalized cell therapy called lifileucel (LN-144/LN-145) for people with advanced uveal melanoma (a type of eye cancer) or certain sarcomas (undifferentiated pleomorphic sarcoma or dedifferentiated liposarcoma). The treatment involves removing imm…

This study tests whether the drug quisinostat can prevent uveal melanoma, a rare eye cancer, from spreading to other parts of the body. It involves 63 high-risk patients whose primary tumor has been treated. The main goal is to see how long participants stay free of distant cance…

This study tests a new treatment for advanced melanoma that has not responded to standard therapies. Doctors take immune cells from a patient's tumor, boost them with a molecule called CD40L, and return them to the patient after a short course of chemotherapy. The goal is to see …

This phase 3 trial tests whether the drug tebentafusp can prevent uveal melanoma from coming back in high-risk patients after their initial treatment. About 290 people with a specific genetic marker (HLA-A*02:01) will either receive weekly infusions of tebentafusp or be observed …

This study tests a drug called tebentafusp in people with a specific type of advanced eye cancer (uveal melanoma) that has spread to other parts of the body. The drug is designed to help the immune system attack cancer cells. Researchers will also use a blood test to measure tumo…

This study tests a new drug (BI-1206) combined with an existing immunotherapy (pembrolizumab) in people with advanced solid tumors that have stopped responding to standard treatments. The goal is to find a safe dose and see if the combination can help control the cancer. About 19…

This early-phase study tests a new drug, NN3201, designed to seek out and attack cancer cells that have a specific marker called c-Kit. The trial includes people with advanced or spreading cancers such as gastrointestinal stromal tumors (GIST), small-cell lung cancer, and several…

This early-phase trial tests a new treatment for people with advanced melanoma or other solid tumors that have spread. Doctors take a patient's own immune cells, modify them in a lab to better recognize and attack cancer, and give them back after a short course of chemotherapy. T…

This study is looking for 500 people with certain cancers (like eye or skin melanoma, kidney cancer, or mesothelioma) and their family members to understand how common BAP1 gene mutations are. Researchers will collect medical history and questionnaires to learn about cancer risks…

This study follows 700 people with uveal melanoma (a rare eye cancer) who are at high risk of the cancer spreading to the liver. Researchers will collect blood samples and medical data to find early signs of metastasis. The goal is to personalize follow-up care based on each pers…

This study tracks how choroidal melanoma and its treatment affect patients' quality of life. It involves 15 people already in a larger Phase 3 trial. Participants fill out questionnaires about their well-being over two years. No new drugs or procedures are tested here.

This study aims to find new genes that may cause a hereditary risk for uveal melanoma, a rare eye cancer. Researchers will analyze the DNA of 50 patients with this cancer to identify unknown genetic changes. The goal is to improve screening and surveillance for families affected …

This study looks at how the liver's immune system reacts to a chemotherapy drug called melphalan, given directly to the liver through a special procedure. It involves 10 adults with uveal melanoma that has spread to the liver. The goal is to understand immune changes, not to test…