UVEAL MELANOMA

This early-phase trial tests a radioactive drug called 225Ac-MTI-201 in people with metastatic uveal melanoma, a rare eye cancer that has spread to other parts of the body. The main goal is to find the safest dose and understand side effects. Only 16 participants will receive a s…

This phase 2 trial tests the drug darovasertib in 160 people with uveal melanoma, a rare eye cancer. The drug is given before and after standard treatments like surgery or radiation. The main goals are to see if it can help some patients avoid eye removal, reduce radiation needed…

This phase II trial tests two drugs—olaparib and pembrolizumab—together in 12 people with advanced uveal melanoma, a rare eye cancer that has spread. The goal is to see if the combination can shrink tumors or slow the disease. The study is active but no longer recruiting, and res…

This early-phase trial tests whether injecting the chemotherapy drug melphalan directly into the eye's blood vessels can shrink large uveal melanomas (a type of eye cancer) enough to then treat them with radiation. Ten adults with tumors at least 8 mm thick will receive the chemo…

This study tests a treatment that uses a patient's own immune cells (T-cells) to fight advanced melanoma. Some participants also receive a dendritic cell vaccine to boost the immune response. The goal is to see if the T-cells last longer and work better against the cancer. The tr…

This early-stage study tests a new drug called IOA-244 in about 210 adults with advanced or metastatic cancers like lung cancer, melanoma, and lymphoma. The main goal is to see if the drug is safe and tolerable, both alone and combined with other treatments. Researchers also chec…

This study tests a new drug called roginolisib in adults with advanced uveal melanoma, a rare eye cancer that has spread. About 85 participants will receive either roginolisib or standard treatment to see if the drug helps them live longer and improves their quality of life. The …

This study screens up to 1,150 adults with advanced solid tumors (like head and neck, cervical, or lung cancer) to see if they have the right genetic markers and tumor features for future T-cell therapies. Researchers will test blood and tumor samples for HLA type and other marke…

This study follows 500 adults with uveal melanoma (a rare eye cancer) to measure how diagnosis and treatment affect their quality of life, mental health, and decision-making. Participants complete surveys before treatment and for five years after. The goal is to better understand…

This study looks at whether eating a high-fiber diet can change the gut bacteria of people with advanced melanoma who are receiving standard immunotherapy. About 50 participants will be randomly assigned to either a high-fiber or a healthy control diet for a set period. The main …

This study tests whether a video-based educational program can help people who have had uveal melanoma (a rare eye cancer) better understand their disease and feel more in control. About 108 adults who completed treatment are randomly assigned to watch the video or receive usual …