TREATMENT

This study tests a personalized vaccine created from a patient's own immune cells (dendritic cells) that are trained to attack unique markers on their tumor. It is for people with advanced solid tumors who have not responded to standard treatments. The main goal is to check safet…

This study compares two types of acid-reducing medications—vonoprazan (a newer drug) and rabeprazole (a standard drug)—when used with bismuth and two antibiotics to treat H. pylori infection. About 320 adults with confirmed H. pylori who have not been treated before will receive …

This phase 2 trial tests whether combining rituximab with daratumumab can raise platelet counts in adults with immune thrombocytopenia (ITP) who have not responded to steroids. Twenty participants will receive one dose of rituximab and eight doses of daratumumab over eight weeks.…

This study tests whether changing treatments after an early relapse helps smokers quit. 544 smokers who want to quit will try nicotine patches, lozenges, varenicline, or e-cigarettes. If they slip in the first few weeks, they may switch to a different option. All visits are remot…

This study tests whether adding an anti-CD38 antibody to the standard drug rituximab works better than rituximab alone for adults with immune thrombocytopenia (ITP) whose platelet counts stayed low or came back after steroid treatment. About 160 participants will receive either t…

This study tests a micropulse laser for diabetic macular edema, a condition causing vision loss in people with diabetes. Fifty participants with initial or stubborn swelling will receive the laser treatment. Researchers will measure changes in vision and retinal thickness to see …

This study tests a combination of three drugs—venetoclax, ivosidenib, and azacitidine—in adults with a specific genetic form of acute myeloid leukemia (IDH1-mutated AML). The goal is to see if this triple therapy can improve remission rates and survival compared to standard treat…

This early-stage study tests whether stem cells from human amniotic fluid can help heal painful skin wounds (calciphylaxis) in people with chronic kidney disease. Nine participants will receive the stem cell treatment, and researchers will measure wound healing and pain levels. T…

This study tests an experimental drug called Anti-CD38 antibody in 60 children aged 6 and older who have immune thrombocytopenia (ITP), a condition where the immune system destroys platelets, causing bleeding risks. The participants have not responded well to standard treatments.…

This study compares two antibody drugs—daratumumab and rituximab—in 160 adults with immune thrombocytopenia (ITP) whose condition did not improve or came back after steroid treatment. The goal is to see which drug works better at raising platelet counts and reducing bleeding risk…

This study tests two types of special glasses (D.S.D.O. lenses) designed to slow the progression of nearsightedness (myopia) in children aged 6 to 14. About 120 children will wear the glasses daily for one year and have regular eye checkups. The goal is to see if these lenses can…

This study tests whether a combination of Chinese herbs (Ziyin-Xiehuo) and intradermal acupuncture can help control idiopathic precocious puberty in girls. About 170 girls aged 7.5 or younger with early signs of puberty will receive either the treatment or a placebo. The goal is …

This study tests a new drug, daratumumab, against an older one, rituximab, in children aged 6 to 17 with immune thrombocytopenia (ITP) that didn't improve with steroids. ITP causes low platelets and easy bleeding. The goal is to see which drug works better at raising platelet cou…

This study tests a new treatment for children, teens, and young adults (ages 2 to 34) newly diagnosed with classical Hodgkin lymphoma. The drug brentuximab vedotin replaces two older drugs to see if it can shrink tumors faster and more completely, so fewer patients need radiation…

This study tests whether doing more aerobic exercise than usual can help teens aged 13-18 recover faster from a concussion. Participants start within 14 days of injury and are assigned to either high-dose exercise (over 150 minutes per week at a safe intensity) or standard care. …

This study tests a sleep health program for teens aged 10-19 who recently had a concussion. The goal is to see if better sleep helps symptoms go away faster and improves sleep quality, mood, and school engagement. Participants will be randomly assigned to the sleep program or sta…

This study compares two surgical techniques for removing a uterine septum—a wall of tissue inside the uterus that can cause pregnancy complications. One method uses scissors without electricity, while the other uses a heated wire. Researchers will track surgery time, costs, and r…

This study aims to find out which patient factors influence how well a nerve block works for medication-overuse headache. Researchers will give 70 adults an ultrasound-guided injection and track their pain and medication use for one month. The goal is to better predict who will b…