TREATMENT

This study tests a personalized vaccine created from a patient's own immune cells (dendritic cells) that are trained to attack unique markers on their tumor. It is for people with advanced solid tumors who have not responded to standard treatments. The main goal is to check safet…

This study tests a special laser (micropulse) to treat diabetic macular edema, a condition where fluid builds up in the center of the retina and blurs vision. Researchers will enroll 50 adults with diabetes who have either new or stubborn swelling. The goal is to see if the laser…

This study tests a combination of three drugs (venetoclax, ivosidenib, and azacitidine) in adults with a specific genetic form of acute myeloid leukemia (AML) called IDH1-mutated. The goal is to see if this triple therapy can improve remission rates and survival. About 23 partici…

This study tests two types of special glasses (D.S.D.O. lenses) designed to slow the progression of nearsightedness (myopia) in children aged 6 to 14. About 120 children will wear the glasses daily for one year and have regular eye checkups. The goal is to see if these lenses can…

This study tests whether changing treatments based on how well a person responds can help smokers quit. Participants will receive free nicotine patches, lozenges, varenicline, or e-cigarettes for 12 weeks. The study involves 544 adult smokers who want to quit, with all visits don…

This study tests whether a combination of Chinese herbs (Ziyin-Xiehuo) and intradermal acupuncture can help control idiopathic precocious puberty in girls. About 170 girls aged 7.5 or younger with early signs of puberty will receive either the treatment or a placebo. The goal is …

This study tests a new drug called Anti-CD38 antibody in 60 children aged 6 and older with immune thrombocytopenia (ITP), a condition where the immune system destroys platelets, causing bleeding. The drug aims to raise platelet counts safely in patients who have not improved with…

This study tests a new drug, daratumumab, against an older one, rituximab, in children aged 6 to 17 with immune thrombocytopenia (ITP) that didn't improve with steroids. ITP causes low platelets and easy bleeding. The goal is to see which drug works better at raising platelet cou…

This study tests whether adding an anti-CD38 antibody to the standard drug rituximab works better than rituximab alone for adults with immune thrombocytopenia (ITP) who did not improve or relapsed after steroid treatment. About 160 participants will receive either the combination…

This study compares two antibody drugs, daratumumab and rituximab, in 160 adults with immune thrombocytopenia (ITP) whose condition did not improve or came back after steroid treatment. The goal is to see which drug better raises platelet counts and reduces bleeding risk. Partici…

This study tests whether a newer acid-blocking drug (P-CAB) works better than a standard one (PPI) when used as part of a four-drug treatment for H. pylori, a stomach infection that can cause ulcers. About 320 adults who have not been treated before will receive either the P-CAB …

This study tests a new treatment for children, teens, and young adults (ages 2 to 34) newly diagnosed with classical Hodgkin lymphoma. The drug brentuximab vedotin replaces two older drugs to see if it can shrink tumors faster and more completely, so fewer patients need radiation…

This study tests whether combining two drugs—rituximab and daratumumab—can safely raise platelet counts in adults with immune thrombocytopenia (ITP) who did not get better with steroids. About 20 people will receive the combo and be followed for 12 weeks to see if their platelet …

This early-stage study tests whether stem cells from the amniotic sac can help heal painful wounds in people with calciphylaxis, a rare and serious condition linked to chronic kidney disease. Nine adults aged 18-75 will receive the treatment and be monitored for wound healing and…

This study looks at whether a higher amount of aerobic exercise (like brisk walking or cycling) can help teenagers recover faster from a concussion. Researchers will compare a standard exercise program to a higher-dose one, starting within two weeks of injury. The goal is to see …

This study tests a sleep health program for teens aged 10-19 who recently had a concussion. The goal is to see if better sleep helps symptoms go away faster and improves sleep quality, mood, and school engagement. Participants will be randomly assigned to the sleep program or sta…

This study aims to find out which patient factors influence how well a nerve block works for medication-overuse headache. Researchers will give 70 adults an ultrasound-guided injection and track their pain and medication use for one month. The goal is to better predict who will b…

This study compares two surgical techniques for removing a uterine septum, a wall of tissue inside the uterus that can cause problems. Researchers want to see if using scissors without electricity is better than using an electric tool. The study will look at surgery time, cost, c…