TOBACCO USE DISORDER

This study tests a smartphone-based program that gives veterans small rewards for staying smoke-free before and after major elective surgery. Smoking raises the risk of problems like infections and longer hospital stays after surgery. The program uses breath tests to confirm abst…

This study tests whether varenicline (Chantix) helps people quit cigarettes and reduce cannabis use. About 200 adults in South Carolina who smoke and use cannabis will get either the drug or a placebo, plus counseling. All visits are done remotely.

This study tests if a non-invasive brain stimulation technique called rTMS can help people with mental illness quit smoking. Forty daily smokers with a psychiatric condition will either receive rTMS or standard care. Researchers will also talk to patients and doctors to see if ad…

This study tests whether the drug cytisinicline can change how the brain reacts to seeing smoking-related images. 64 daily smokers who are not trying to quit will receive either the drug or a placebo and undergo brain scans. The goal is to see if the drug reduces brain activity l…

This study tests a free, internet-based program that uses mindfulness and behavioral strategies to help adults reduce or quit smoking and vaping. About 406 adults in Switzerland and Türkiye who smoke or vape will be randomly assigned to the program or a control group. The program…

This study tests whether practicing mindfulness meditation in a virtual reality environment can reduce cigarette cravings and help people quit smoking for good. About 200 smokers who use 10-40 cigarettes daily will be split into two groups: one will do six weekly VR mindfulness s…

This study tests whether adding ear acupressure (small seeds taped to ear points) to standard nicotine patches can better reduce cravings, withdrawal symptoms, and anxiety in psychiatric patients who must stop smoking while in the hospital. About 60 adults aged 18-65 will be rand…

This study tests a program called Contingency Management (CM) that gives rewards to Veterans who quit smoking, verified by breath tests. Researchers will first gather feedback from Veterans and staff, then test the mobile program with 20 Veterans over 5 weeks. The goal is to see …

This study tests whether a 5-day course of accelerated deep transcranial magnetic stimulation (aTMS) can help adults aged 18-65 quit smoking. About 40 participants will receive 4 brain stimulation sessions daily for 5 days. The main goal is to see if the treatment is tolerable an…

This study is testing whether a compound from cannabis called cannabidiol (CBD) can help people stop smoking tobacco. Researchers will give oral CBD to 50 adults who smoke at least 10 cigarettes daily and want to quit. The goal is to see if CBD increases short-term tobacco abstin…

This study tests a new way to help veterans with PTSD stop smoking. It combines counseling, nicotine gum, and a noninvasive brain stimulation called TMS. Researchers want to see if this approach is feasible and helps veterans stay smoke-free for at least 3 months. The study will …

This study tests whether cannabidiol (CBD), a compound from cannabis, can help people who want to quit smoking reduce their cigarette use. About 120 adults with tobacco use disorder will receive either CBD or a placebo twice daily for 56 days. Researchers will measure nicotine le…

This study tests whether clavulanic acid, a drug used in some antibiotics, can help adult smokers reduce their cigarette use. About 30 heavy smokers will receive either the drug or a placebo, and researchers will track changes in smoking behavior and brain activity using MRI scan…

This study observes 200 people already taking psychedelics in other trials to understand how these drugs alter brain information processing. Researchers will use brain scans, computer tasks, and interviews to measure changes in perception, belief flexibility, and electrical activ…

This study looks at how a beta-blocker (propranolol) and nicotine patches, alone or together, affect smokers' brain activity and cravings when they see smoking-related cues. About 80 daily smokers will have MRI scans and rate their urges. Participants do not try to quit or take t…

This study tests a program that combines help to quit smoking with lung cancer screening for African American smokers. About 250 people will take part. The goal is to see if this combined approach helps more people stop smoking and get screened, reducing lung cancer deaths in thi…