SYSTEMIC SCLEROSIS

This study tested the drug bosentan in 18 adults with systemic sclerosis (scleroderma) who had poor blood flow in their hands and a history of digital ulcers. The goal was to see if bosentan could improve hand blood flow, measured by laser imaging, and to understand how blood flo…

This study tested whether adding a strong immune-suppressing drug (cyclophosphamide) to standard steroid treatment (prednisone) could help stabilize or improve lung function in people with scleroderma-related lung scarring. Forty adults with worsening lung function took part. The…

This study tested whether giving a stem cell transplant early is better than standard immunosuppressive drugs for people with early, severe scleroderma (a rare autoimmune disease that causes skin hardening and organ damage). Sixty adults aged 18-65 were randomly assigned to eithe…

This early study tested a drug called nemolizumab in 6 adults with systemic sclerosis, a rare disease that causes skin to harden and tighten. The main goal was to see if the drug could reduce skin thickness over 24 weeks. Researchers also checked for side effects and how the drug…

This study tested whether MRI can detect and monitor interstitial lung disease (lung scarring) in people with scleroderma. Twenty-five adults with scleroderma underwent both MRI and CT scans. A subset also breathed in a special xenon gas to see how well their lungs exchange oxyge…

This study tested whether a painless, non-radiation ultrasound of the chest can find early signs of lung scarring in people with scleroderma. Thirty patients without known lung disease on CT scans underwent thoracic ultrasound. The goal was to see how often ultrasound detects hid…

This study tested a smartphone app called RENEW designed to help people with scleroderma manage fatigue and build resilience. Over 12 weeks, 43 participants used the app to set and track weekly healthy goals. The main goal was to see if people would actually use the app and compl…

This study tested whether a personalized home respiratory rehabilitation program is feasible for people with systemic sclerosis (scleroderma) who have early lung disease. Fifteen participants completed a 3-month program with one supervised session followed by home exercises. The …

This trial tested an online self-management program for people with scleroderma, a chronic autoimmune disease. The program includes educational videos and group video calls led by trained peers. The goal was to see if it helps patients feel more confident managing their condition…

This study tested whether rituximab, a drug used for certain cancers and autoimmune diseases, can reduce joint pain and swelling in people with scleroderma (systemic sclerosis) who have arthritis. 22 participants with active arthritis took the drug. The main goal was to see if it…

This study compared two commercially available devices that measure how well the lungs transfer nitric oxide and carbon monoxide. Nine adults with systemic sclerosis and related lung disease took part. Each person was tested with both devices in random order to see if the results…

This study followed 150 adults with systemic sclerosis (scleroderma) for two years to track their nutritional health. Researchers measured weight, diet, and disease severity every six months. If malnutrition was found, patients received dietary advice or supplements. The goal was…

This completed study involved 214 people with systemic sclerosis (scleroderma) to find out how often calcium deposits form in the hands and feet. Researchers used X-rays to detect these deposits and checked if they were linked to damage in organs like the lungs or heart. The goal…

This study looked at 629 adults with different types of pulmonary arterial hypertension (PAH), including those linked to HIV, heart defects, and connective tissue diseases. Researchers checked for specific antibodies that might help predict how the disease will progress. The goal…

This study aimed to create a standard way to measure how systemic sclerosis (a rare autoimmune disease) affects patients' daily lives. Researchers worked with 100 patients and experts to identify the most important areas to assess, like mobility, pain, and social participation. T…

This completed study examined whether eosinophils, a type of white blood cell, contribute to fibrosis (scarring) in systemic sclerosis, an autoimmune disease. Researchers compared blood samples from 40 patients with systemic sclerosis and 30 healthy volunteers, with optional skin…

This study looked at the experiences of family members who care for someone with systemic sclerosis (scleroderma), a rare and serious disease. Researchers surveyed 50 caregivers to understand their physical, mental, and social challenges. The goal is to use this information to cr…

This study looked at how skin changes from systemic sclerosis affect a person's feelings about their appearance. Researchers compared 170 patients with the disease to healthy people using surveys about body image and emotional distress. The goal was to understand the burden of th…

This study tested whether a special MRI technique can measure lung scarring (fibrosis) in people with scleroderma. 24 adults with scleroderma had MRI scans of their lungs while breathing in and out. The goal was to see if MRI could provide a safe, radiation-free way to track lung…

This study looked at 30 adults with systemic sclerosis (scleroderma) to see how the disease affects blood vessels in the arms and belly. Researchers used a special ultrasound to check the radial, ulnar, and splanchnic vessels. The goal was to better understand blood vessel proble…

This study looked at 235 people to understand how certain immune cells, called innate T cells, might be involved in systemic sclerosis (a rare disease that causes hardening of the skin and organs). Researchers compared patients with systemic sclerosis to those with other autoimmu…

This study looked at how blood vessel cells and immune cells talk to each other in people with systemic sclerosis, a rare autoimmune disease that causes skin hardening. Researchers collected skin samples from 350 adults aged 18 to 75 to measure a specific protein (OX40L) on blood…

This study followed 56 adults with systemic sclerosis (scleroderma) who also had a serious lung complication called diffuse infiltrating pneumonia. Researchers measured lung function at 12 and 24 months to see how it changed and to identify factors that might predict faster decli…