SYSTEMIC SCLEROSIS

This Phase 3 trial tests whether the oral drug nerandomilast can slow disease progression and improve symptoms in people with systemic sclerosis, a rare autoimmune disease that causes skin thickening and organ damage. About 448 adults with limited or diffuse systemic sclerosis wi…

This early-stage trial tests a new drug called HBM7020 in 63 people. It starts with healthy volunteers to check safety, then moves to patients with autoimmune diseases like lupus, rheumatoid arthritis, scleroderma, and Sjögren's disease. The goal is to see if the drug is safe and…

This study tests a new treatment using CD19 CAR T cells for people with severe autoimmune diseases that haven't improved with standard therapies. The treatment involves collecting a patient's own immune cells, modifying them to target and destroy certain immune cells, and infusin…

This early study tests a new treatment called CD19 UCAR-T cells for people with autoimmune diseases like lupus, vasculitis, and Sjögren's syndrome. The therapy uses modified immune cells to target and calm the overactive immune system. The main goals are to check safety and see i…

This early-phase trial tests a single dose of universal (off-the-shelf) CAR-T cells in 30 adults with active autoimmune diseases like lupus, scleroderma, vasculitis, myositis, or Sjögren's. The treatment targets CD19 and BCMA on immune cells to reset the faulty immune system. The…

This study will use Doppler ultrasound to measure blood flow in the gut arteries of 74 people with systemic sclerosis (scleroderma) and compare them to healthy volunteers. The goal is to see if changes in gut blood flow are linked to digestive symptoms and other organ problems. T…

This study will collect health data and samples from 100 adults with rheumatoid diseases when they change treatments. Researchers will use artificial intelligence to find patterns that could predict when a treatment change is needed. The goal is to improve personalized care and u…

This study looks at sleep breathing problems in 30 adults with systemic sclerosis (scleroderma). Participants will have an overnight sleep test to measure pauses in breathing. The goal is to find out how common these sleep issues are in people with scleroderma.

This study looks at whether a substance in the blood called catestatin can be used to measure disease activity and heart-related problems in people with systemic sclerosis (scleroderma). Researchers will compare catestatin levels in 70 adults with the disease to those in healthy …

This study is creating a large collection of medical data and blood samples from 450 adults with autoimmune diseases (rheumatoid arthritis, lupus, or scleroderma) and 50 healthy volunteers. Researchers will use advanced lab techniques to find unique biological markers that could …

This study aims to find the best way to share research results with people who have scleroderma, a rare autoimmune disease. About 128 participants will be randomly assigned to receive either an infographic or a plain-language summary of a study. They will then rate how complete, …