SUBSTANCE USE DISORDERS

This study tests whether a virtual reality (VR) experience can help people who are in early recovery from stimulant use disorder reduce their drug use and stay abstinent longer. Researchers will compare a VR group to a control group to see if the VR tool improves future thinking,…

This study tests whether a low dose of ketamine, given through an IV, can help adults with moderate to severe methamphetamine use disorder reduce their drug use. 120 participants will receive either ketamine or a placebo over six weeks, and researchers will check urine samples to…

This study tests whether training people who inject drugs to become peer educators can help their friends get tested for HIV and start prevention tools like PrEP or treatment for opioid use. About 360 participants from syringe service programs in Maryland will be split into two g…

This study tests if adding extra supports to a group parenting program can improve early language development in children (12-42 months old) of parents with substance use disorder. Researchers will compare child language outcomes between families receiving the standard program an…

This study tests whether starting a quit attempt during the first half of the menstrual cycle (follicular phase) helps women stop smoking more successfully than starting during the second half (luteal phase) or without cycle timing. About 1,200 women who smoke daily and have regu…

This study tests a device that gently stimulates a nerve in the ear to help people going through alcohol withdrawal. Twenty adults with alcohol use disorder will wear the device for 5 days during detox. The goal is to see if it reduces withdrawal symptoms, cravings, and the need …

This study tests whether low intensity focused ultrasound (LIFU) can safely help people with opioid or other substance use disorders. About 29 adults currently in treatment will receive the ultrasound procedure. The main goal is to check for side effects and see if the treatment …

This study tests a brief computer program designed to help teenagers aged 13 to 17 reduce their use of cannabis and alcohol. Participants who are already seeking treatment for these substances will use the program and be followed up at one and three months. The goal is to see if …

This study tests a painless, non-surgical brain stimulation method called temporal interference (TI) to see if it can reduce nicotine cravings and vaping. 120 adults who vape heavily will receive either real TI to a deep brain area or a fake (sham) treatment during a single sessi…

This study aims to develop and test a virtual reality tool to help young people aged 15-30 who have experienced trauma and are at risk for substance use disorders and HIV. Participants include young men who have sex with men and others with substance use issues. The tool is desig…

This study is testing whether a telemedicine program can help people living with HIV who also have substance use disorders get the care they need. Researchers will enroll 30 adults from HIV clinics in Alabama to see if the program is practical and well-received. The main goal is …

This study looks at whether a tool called MyPath helps women with substance use disorder make informed choices about birth control after having a baby. About 400 women will use the tool during pregnancy or right after giving birth. Researchers will track which birth control metho…

This study looks at whether having a trained peer recovery specialist in the emergency room helps people with substance use disorders connect to treatment and support. About 400 adults who visit the ER for substance-related issues will be followed for 6 months. Researchers will c…

This study is testing a new family-based program (Fam-AID) for teenagers aged 13-21 who have both a substance use disorder and an internalizing disorder like anxiety or depression. The program adds extra support to their usual treatment by involving family members and teaching co…

This study tests a method called FIT (Feedback Informed Treatment) in social services. Clients regularly rate their main problems and how they feel about the help they receive. The goal is to see if this feedback helps prevent dropouts and improves outcomes for 400 people dealing…

This study tests whether cognitive remediation—a type of brain training with coaching—can improve thinking skills and reduce aggressive behavior in 30 adults staying in a forensic mental health unit. Participants have conditions like psychosis, ADHD, or substance use disorders. T…

This study looks at whether brain activity related to learning can predict how well teens respond to a program aimed at reducing cannabis use. Teens aged 14-17 get a brain scan, then attend 10 weekly virtual sessions where they report use and take drug tests. They can earn prizes…