SUBSTANCE USE DISORDERS

This study tests if using a phone app called the Safe and Sound Protocol (SSP) can help adults who are in treatment for substance use and have a history of trauma. About 100 people will either use the real app or a fake version for up to 5 hours over a week. Researchers will chec…

This early-stage study tests whether a single dose of psilocybin (the active ingredient in magic mushrooms) combined with talk therapy is safe and can reduce depression and substance use in veterans and first responders who haven't responded to standard treatments. Fifty particip…

This study will test if a technology-based tool is helpful and easy to use for people living in supportive housing who also have substance use issues. About 25 residents and staff will try the tool, which includes videos and rewards, for two weeks. The goal is to see if it improv…

This study looks at how kratom affects people who have used opioids in the past. Researchers will compare kratom to another substance and a placebo to understand its safety, how the body processes it, and how it makes people feel. The goal is to gather information about kratom's …

This study will test whether a mobile app that teaches people about the brain science of addiction is easy to use and helpful. Researchers will enroll 40 adults who are currently being treated for opioid or stimulant use disorder. Participants will use the app and answer question…

This study examines whether recent federal policy changes made it easier for veterans with opioid or alcohol use disorders to get and stay on medication-assisted treatment. Researchers will compare treatment use, retention, and outcomes before and after the policy changes using d…

This study tests a 12-week one-on-one support program for people who care for a loved one recently treated for substance use. Researchers want to see if the program is easy to complete and if participants find it helpful. About 18 adults will join weekly telehealth sessions and s…

This study looks at what happens to your brain, hunger, mood, and daily life when you briefly stop taking tirzepatide (a medication for blood sugar and appetite) and then restart it. Researchers will track 40 adults aged 18-70 who are already on tirzepatide, using brain scans, qu…