STAGE IVB LUNG CANCER AJCC V8

This study tests a vaccine called CIMAvax combined with immunotherapy drugs (nivolumab or pembrolizumab) in people with advanced non-small cell lung cancer or head/neck cancer that has spread. The goal is to find the best dose and see if the combination helps control tumor growth…

This study tests a new drug called pevonedistat combined with standard chemotherapy (carboplatin and paclitaxel) in people with advanced non-small cell lung cancer that has not responded to immunotherapy. The goal is to see if this combination can shrink tumors or slow cancer gro…

This study is for people with advanced non-small cell lung cancer that has come back or spread. It tests a combination of two drugs: trametinib, which blocks cancer cell growth, and pembrolizumab, which helps the immune system attack cancer. The goal is to see if this combination…

This early-phase trial tests two experimental drugs, sapanisertib and telaglenastat, in people with advanced non-small cell lung cancer that has spread to the brain or other areas. The goal is to find the safest dose and see if the combination can shrink tumors or slow the diseas…

This early-phase study is for people with a specific kind of advanced lung cancer (ALK-positive non-small cell lung cancer) that has gotten worse despite prior ALK-targeted therapy. Researchers are testing a combination of two drugs—brigatinib and bevacizumab—to see what dose is …

This study tests a combination of three drugs (niraparib, temozolomide, and atezolizumab) in people with advanced solid tumors or extensive-stage small cell lung cancer that responded to initial chemotherapy. The goal is to find the safest dose and see if the combo helps keep can…

This study tests whether a cancer drug called atezolizumab can be given safely at home to people with non-small cell lung cancer. Instead of going to a clinic, patients receive the injection under the skin from a nurse while using telemedicine. The goal is to see if this home-bas…

This study tests a new drug (aurora kinase inhibitor) combined with a standard targeted therapy (osimertinib) for people with advanced EGFR-mutant non-small cell lung cancer. The goal is to find the safest dose and see if the combination can better control tumor growth. About 32 …

This study tests a combination of three drugs (docetaxel, ramucirumab, and pembrolizumab) in 30 people with advanced non-small cell lung cancer that worsened after standard chemotherapy and immunotherapy. The goal is to see if this triple therapy is safe and works better than cur…

This early-phase study tests a new combination of two drugs, minnelide and osimertinib, for people with advanced non-small cell lung cancer that has a specific gene change (EGFR mutation). The main goal is to find the safest dose and see how the body responds. Only 8 participants…

This early-phase study tests a new drug combination for people with advanced ALK-positive non-small cell lung cancer that has spread or come back. The goal is to find the safest dose of the targeted drug ensartinib when given with standard chemotherapy (carboplatin, pemetrexed) a…

This early trial tests whether adding surgery or radiation to the targeted drug brigatinib can better control advanced ALK-positive non-small cell lung cancer. About 35 people whose cancer has spread or returned will receive both treatments. The main goal is to check safety and s…

This study looks at whether adding surgery or radiation to the targeted drug osimertinib helps people with advanced EGFR-mutant lung cancer live longer without their cancer growing. About 173 adults with stage IIIB or IV non-small cell lung cancer that has a specific EGFR mutatio…

This study tests whether adding tocilizumab to standard immunotherapy (ipilimumab and nivolumab) can reduce severe side effects in people with advanced melanoma, lung cancer, or bladder cancer. About 35 participants will receive the combination to see if it is safer and still eff…

This early-phase study tests a new treatment for people with advanced non-small cell lung cancer that no longer responds to standard immunotherapy. The treatment uses immune cells from donated umbilical cord blood that are genetically modified to better recognize and attack cance…

This study compares two treatments for lung tumors: microwave ablation (using heat to kill cancer cells) and surgical wedge resection (removing a small piece of lung). It includes people with early or advanced lung cancer, sarcoma, or colorectal cancer that has spread to the lung…

This study tests a drug called AMG 510 in people with advanced lung cancer that has a specific genetic change (KRAS G12C mutation). The drug is designed to block the cancer's growth signal. About 116 participants will receive the treatment to see if it shrinks tumors and how safe…

This study tests a new treatment combination for people with extensive-stage small cell lung cancer (ES-SCLC) who haven't had treatment yet. It combines a PARP inhibitor (olaparib), an immunotherapy drug (durvalumab), standard chemotherapy (carboplatin and etoposide), and radiati…

This early-stage trial tests a combination of all-trans retinoic acid (ATRA), a drug made from vitamin A, and atezolizumab, an immunotherapy, in 18 adults with advanced non-small cell lung cancer that has returned or spread. The main goal is to find the safest dose and understand…

This study tests a drug called selpercatinib (LOXO-292) in people with a specific type of advanced or recurrent non-small cell lung cancer that has a RET gene fusion. The drug works by blocking enzymes that help cancer cells grow. About 124 participants will receive the treatment…

This study tests whether adding two antibody drugs (necitumumab and trastuzumab) to the standard pill osimertinib can shrink tumors in people with advanced EGFR-mutated lung cancer that has stopped responding to osimertinib alone. About 30 adults with stage IV non-small cell lung…

This study tests a nurse-led program designed to help people with advanced lung or gynecologic cancer cope with fears about the future. About 42 participants will try the program to see if it is practical and helpful in medical centers and clinics. The goal is to learn if this ap…

This study looks at whether using a precise, targeted form of radiation (stereotactic radiosurgery) instead of whole-brain radiation can help preserve brain function in people with small cell lung cancer that has spread to the brain. About 55 participants with up to 10 brain tumo…

This study looks at whether giving a single, precise dose of radiation after lung cancer surgery is safe and causes fewer side effects than the usual weeks-long radiation. About 50 adults with non-small cell lung cancer who had surgery but still have cancer cells at the edge of t…

This study looks at whether a drug called anamorelin can help improve appetite and stop weight loss in people with advanced non-small cell lung cancer who have lost their appetite and weight. About 25 participants will take either the drug or a placebo and share their experiences…

This early-phase trial tests a drug called berzosertib combined with whole brain radiation for people with lung cancer that has spread to the brain. The main goal is to find the safest dose and check for side effects. About 15 adults with non-small cell, small cell, or neuroendoc…

This study tests an online program designed to improve social well-being and emotional support for women being treated for lung cancer. About 70 women with stage I to IV non-small cell lung cancer will take part. The program uses mindfulness and emotional processing techniques to…

This study looks at whether regularly measuring the amount of paclitaxel (a chemotherapy drug) in the blood can help doctors give the right dose to kill cancer while limiting nerve damage. About 22 adults with various solid tumors (like lung, breast, or ovarian cancer) will have …

This study looks at whether watching a short video can help people with metastatic cancer better understand tumor genomic testing. About 243 adults with advanced breast, lung, or other solid tumors will watch the video and answer questions before and after. The goal is to see if …