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New drug targets rare lung cancer mutation in advanced disease

NCT ID NCT04268550

Disease control Sponsor: SWOG Cancer Research Network Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase II trial tests the drug selpercatinib (LOXO-292) in 124 people with stage IV or recurrent non-small cell lung cancer that has a specific genetic change called a RET fusion. The drug works by blocking enzymes that help cancer cells grow. Researchers are measuring how many patients see their tumors shrink and tracking side effects.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Selpercatinib (also called LOXO-292), a drug that blocks certain enzymes to slow or stop cancer cell growth
What this could lead to
If successful, this could provide a new targeted treatment option for people with RET fusion-positive lung cancer, potentially shrinking tumors and delaying progression.
What could go wrong
This is a phase II trial, so it is still early. The drug may not work for everyone, and side effects are possible. Results may not apply to all lung cancer types.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 124 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2020

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

A research network

The lead sponsor is a research network or cooperative group.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients must have been assigned to S1900B based on biomarker analysis of tissue and/or blood and determined to have RET fusion-positive NSCLC as defined here: * Patients must have RET fusion-positive NSCLC as determined by the Foundation Medicine (FMI) tissue-assay, other tumor-based assays such as next-generation sequencing (NGS), polymerase chain reaction (PCR), or follicular in situ hybridization (FISH), or by cfDNA blood assay. Patients with RET fusions detected by immunohistochemistry (IHC) alone are not eligible. The testing must be done within a laboratory with Clinical Laboratory Improvement Act (CLIA), International Organization for Standardization (ISO/International Electrotechnical Commission (IEC), College of American Pathologists (CAP), or similar certification. Presence of RET fusions detected on tests performed outside of LUNGMAP must have been confirmed by the study biomarker review panel * For patients whose prior therapy was for stage IV or recurrent disease, the patient must have received at least one line of a platinum-based chemotherapy regimen. For patients whose prior systemic therapy was for stage I-III disease only (i.e. patient has not received any treatment for stage IV or recurrent disease), disease progression on platinum-based chemotherapy must have occurred within one year from the last date that the patient received that therapy. Prior anti-PD-1/PD-L1 therapy, alone or in combination (e.g. nivolumab, pembrolizumab, or durvalumab) is allowed * Patients must be negative for all additional validated oncogenic drivers that could cause resistance to LOXO-292 treatment. This includes EGFR sensitizing mutations, EGFR T790M, ALK gene fusion, ROS1 gene fusion, KRAS activating mutation, BRAF V600E mutation and MET exon 14 skipping mutation or high-level amplification and expression * Note: EGFR, ALK, ROS, KRAS, and BRAF testing is performed as part of the LUNGMAP screening/pre-screening FoundationOne test. If prior data is not available, results from the FMI testing must be obtained prior to sub-study registration * Patients must have measurable disease documented by computed tomography (CT) or magnetic resonance imaging (MRI). The CT from a combined positron emission tomography (PET)/CT may be used to document only non-measurable disease unless it is of diagnostic quality. Measurable disease must be assessed within 28 days prior to sub-study registration. Pleural effusions, ascites and laboratory parameters are not acceptable as the only evidence of disease. Non-measurable disease must be assessed within 42 days prior to sub-study registration. All disease must be assessed and documented on the Baseline Tumor Assessment Form. Patients whose only measurable disease is within a previous radiation therapy port must demonstrate clearly progressive disease (in the opinion of the treating investigator) prior to registration. CT and MRI scans must be submitted for central review via transfer of images and data (TRIAD) * Patients must have a CT or MRI scan of the brain to evaluate for CNS disease within 42 days prior to sub-study registration * Patients with evidence of chronic hepatitis B virus (HBV) infection must have undetectable HBV viral load on suppressive therapy within 28 days prior to registration * Patients with a history of hepatitis C virus (HCV) infection must have been treated and cured. Patients with HCV infection who are currently on treatment must have an undetectable HCV viral load within 28 days prior to registration * Patients with known human immunodeficiency virus (HIV) infection are eligible, provided they are on effective anti-retroviral therapy and have undetectable viral load at their most recent viral load test and within 6 months prior to registration * Patients must be able to swallow capsules * Patients must have progressed (in the opinion of the treating physician) following the most recent line of therapy * Patients must have recovered (=\< grade 1) from any side effects of prior therapy. Patients must not have received any radiation therapy within 14 days prior to sub-study registration * Absolute neutrophil count (ANC) \>= 1,500/mcl (obtained within 28 days prior to sub-study registration) * Platelet count \>= 100,000 mcl (obtained within 28 days prior to sub-study registration) * Serum bilirubin =\< institutional upper limit of normal (IULN) (within 28 days prior to sub-study registration). For patients with liver metastases, bilirubin must be =\< 5 x IULN * Either alanine aminotransferase (ALT) or aspartate aminotransferase (AST) =\< 2 x IULN (within 28 days prior to sub-study registration) (if both ALT and AST are done, both must be =\< 2 IULN). For patients with liver metastases, bilirubin and either ALT or AST must be =\< 5 x IULN (if both ALT and AST are done, both must be =\< 5 x IULN) * Serum creatinine =\< the IULN or calculated creatinine clearance \>= 50 mL/min using the following Cockcroft-Gault formula (within 28 days prior to sub-study registration) * Patients must have Zubrod performance status 0-1 documented within 28 days prior to sub-study registration * Pre-study history and physical exam must be obtained within 28 days prior to sub-study registration * No other prior malignancy is allowed except for the following: adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, adequately treated stage I or II cancer from which the patient is currently in complete remission, or any other cancer from which the patient has been disease free for five years * Patients must have electrolytes and blood urea nitrogen (BUN) performed within 14 days prior to sub-study registration * Patients must agree to have blood specimens submitted for circulating tumor DNA (ctDNA) * Patients must also be offered participation in banking and in the correlative studies for collection and future use of specimens * Patients must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines * As a part of the Oncology Patient Enrollment Network (OPEN) registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system * Patients with impaired decision-making capacity are eligible as long as their neurological or psychological condition does not preclude their safe participation in the study (e.g., tracking pill consumption and reporting adverse events to the investigator) Exclusion Criteria: * Patients must not have received any prior treatment with selective anti-RET inhibitors (anti-RET multikinase inhibitors are permitted) * Patient must not have leptomeningeal disease, spinal cord compression or brain metastases unless: (1) metastases have been locally treated and have remained clinically controlled and asymptomatic for at least 14 days following treatment, and prior to registration, AND (2) patient has no residual neurological dysfunction and has been off corticosteroids for at least 24 hours prior to sub-study registration * Patients must not have received any prior systemic therapy (systemic chemotherapy, immunotherapy or investigational drug) within 14 days prior to sub-study registration * Patients must not be planning to receive any concurrent chemotherapy, immunotherapy, biologic or hormonal therapy for cancer treatment while receiving treatment on this study. Concurrent use of hormones for non-cancer-related conditions (e.g., insulin for diabetes and hormone replacement therapy) is acceptable * Patient must not have had a major surgery within 14 days prior to sub-study registration. Patient must have fully recovered from the effects of prior surgery in the opinion of the treating investigator * Patients must not have any grade III/IV cardiac disease as defined by the New York Heart Association Criteria (i.e., patients with cardiac disease resulting in marked limitation of physical activity or resulting in inability to carry on any physical activity without discomfort), unstable angina pectoris, and myocardial infarction within 6 months, or serious uncontrolled cardiac arrhythmia * Patients must not have a QT interval by Fridericia (QTcF) \> 470 msec based on the electrocardiogram (ECG) within 28 days prior to registration. It is suggested that a local cardiologist review the QTcF intervals * Patients must not have any clinically significant uncontrolled systemic illness, including but not limited to uncontrolled infection, requiring intravenous antibiotics, unstable angina pectoris, myocardial infarction within the past 6 months, uncontrolled cardiac arrhythmias, uncontrolled hypertension, or uncontrolled diabetes mellitus * Uncontrolled diabetes: Patients who have a diagnosis of diabetes must have an hemoglobin (Hb) A1C \< 7% within 28 days prior to registration. The same criterion will be used in patients with confirmed diagnosis of diabetes mellitus who have been on a stable dietary or therapeutic regimen for this condition in the last three months * Uncontrolled blood pressure and hypertension: All blood pressure measurements within the 28 days prior to registration must be systolic blood pressure (SBP) =\< 180 and diastolic blood pressure (DBP) =\< 100. An exception can be made by a healthcare provider for a patient with a single blood pressure elevation who upon rechecking has a blood pressure within the parameters above * Patients must not have any impairment of gastrointestinal function or gastrointestinal disease that may significantly alter the absorption of LOXO-292 (e.g., ulcerative disease, uncontrolled nausea, vomiting, diarrhea, malabsorption syndrome, small bowel resection, or active peptic ulcer disease) * Patients must not be planning to receive any strong inhibitors or inducers of CYP3A4 at least 14 days prior to sub-study registration and throughout protocol treatment * Patients must not be planning to use proton pump inhibitors (PPIs) at least one week prior to sub-study registration and throughout protocol treatment * Patients must not be pregnant or nursing. Women study patients of reproductive potential and fertile men study patients and their partners must abstain or use effective contraception (including barrier method) while receiving study treatment and for at least 3 months after the last dose of LOXO-292. Male study patients must agree not to donate sperm for 6 months after the last dose of LOXO-292. A woman is considered to be of "reproductive potential" if she has had menses at any time in the preceding 12 consecutive months. In addition to routine contraceptive methods, "effective contraception" also includes heterosexual celibacy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) defined as a hysterectomy, bilateral oophorectomy or bilateral tubal ligation. However, if at any point a previously celibate patient chooses to become heterosexually active during the time period for use of contraceptive measures outlined in the protocol, he/she is responsible for beginning contraceptive measures

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Conditions

The condition(s) this trial relates to.

lung cancer lung neoplasm non-small cell lung carcinoma RET fusion positive cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Recurrent lung non-small cell carcinoma Stage IV lung cancer ajcc V8 Stage IVA lung cancer ajcc V8 Stage IVB lung cancer ajcc V8

Contacts and locations

Locations

  • Adams Cancer Center

    Gettysburg, Pennsylvania, 17325, United States

  • Adena Regional Medical Center

    Chillicothe, Ohio, 45601, United States

  • Allegiance Health

    Jackson, Michigan, 49201, United States

  • Alta Bates Summit Medical Center-Herrick Campus

    Berkeley, California, 94704, United States

  • Arnot Ogden Medical Center/Falck Cancer Center

    Elmira, New York, 14905, United States

  • Ascension Saint Joseph Hospital

    Tawas City, Michigan, 48764, United States

  • Ascension Saint Mary's Hospital

    Saginaw, Michigan, 48601, United States

  • Aspirus Medford Hospital

    Medford, Wisconsin, 54451, United States

  • Aspirus Regional Cancer Center

    Wausau, Wisconsin, 54401, United States

  • Aspirus UW Cancer Center

    Wisconsin Rapids, Wisconsin, 54494, United States

  • Atlanta VA Medical Center

    Decatur, Georgia, 30033, United States

  • Aurora Bay Area Medical Group-Marinette

    Marinette, Wisconsin, 54143, United States

  • Aurora BayCare Medical Center

    Green Bay, Wisconsin, 54311, United States

  • Aurora Cancer Care-Grafton

    Grafton, Wisconsin, 53024, United States

  • Aurora Cancer Care-Kenosha South

    Kenosha, Wisconsin, 53142, United States

  • Aurora Cancer Care-Milwaukee

    Milwaukee, Wisconsin, 53209, United States

  • Aurora Cancer Care-Milwaukee West

    Wauwatosa, Wisconsin, 53226, United States

  • Aurora Cancer Care-Racine

    Racine, Wisconsin, 53406, United States

  • Aurora Cancer Care-Southern Lakes VLCC

    Burlington, Wisconsin, 53105, United States

  • Aurora Health Care Germantown Health Center

    Germantown, Wisconsin, 53022, United States

  • Aurora Medical Center in Summit

    Summit, Wisconsin, 53066, United States

  • Aurora Saint Luke's Medical Center

    Milwaukee, Wisconsin, 53215, United States

  • Aurora Sinai Medical Center

    Milwaukee, Wisconsin, 53233, United States

  • Aurora West Allis Medical Center

    West Allis, Wisconsin, 53227, United States

  • Bayhealth Hospital Kent Campus

    Dover, Delaware, 19901, United States

  • Bayhealth Hospital Sussex Campus

    Milford, Delaware, 19963, United States

  • Benefis Healthcare- Sletten Cancer Institute

    Great Falls, Montana, 59405, United States

  • Bon Secours Memorial Regional Medical Center

    Mechanicsville, Virginia, 23116, United States

  • Bon Secours Saint Francis Medical Center

    Midlothian, Virginia, 23114, United States

  • Bon Secours Saint Mary's Hospital

    Richmond, Virginia, 23226, United States

  • Bozeman Deaconess Hospital

    Bozeman, Montana, 59715, United States

  • Bronson Battle Creek

    Battle Creek, Michigan, 49017, United States

  • California Pacific Medical Center-Pacific Campus

    San Francisco, California, 94115, United States

  • Cancer Care Center of O'Fallon

    O'Fallon, Illinois, 62269, United States

  • Cancer Care Specialists of Illinois - Decatur

    Decatur, Illinois, 62526, United States

  • Cancer Care and Hematology-Fort Collins

    Fort Collins, Colorado, 80528, United States

  • Case Western Reserve University

    Cleveland, Ohio, 44106, United States

  • Cherry Tree Cancer Center

    Hanover, Pennsylvania, 17331, United States

  • Columbus Oncology and Hematology Associates Inc

    Columbus, Ohio, 43214, United States

  • Community Hospital of Anaconda

    Anaconda, Montana, 59711, United States

  • Cone Health Cancer Center

    Greensboro, North Carolina, 27403, United States

  • Cone Health Cancer Center at Alamance Regional

    Burlington, North Carolina, 27215, United States

  • Crossroads Cancer Center

    Effingham, Illinois, 62401, United States

  • Delaware Health Center-Grady Cancer Center

    Delaware, Ohio, 43015, United States

  • Doctors Hospital

    Columbus, Ohio, 43228, United States

  • Duluth Clinic Ashland

    Ashland, Wisconsin, 54806, United States

  • Durham VA Medical Center

    Durham, North Carolina, 27705, United States

  • Edwards Comprehensive Cancer Center

    Huntington, West Virginia, 25701, United States

  • Ephrata Cancer Center

    Ephrata, Pennsylvania, 17522, United States

  • Essentia Health - Deer River Clinic

    Deer River, Minnesota, 56636, United States

  • Essentia Health Cancer Center

    Duluth, Minnesota, 55805, United States

  • Essentia Health Hibbing Clinic

    Hibbing, Minnesota, 55746, United States

  • Essentia Health Sandstone

    Sandstone, Minnesota, 55072, United States

  • Essentia Health Virginia Clinic

    Virginia, Minnesota, 55792, United States

  • Fairbanks Memorial Hospital

    Fairbanks, Alaska, 99701, United States

  • Fox Chase Cancer Center

    Philadelphia, Pennsylvania, 19111, United States

  • Fox Chase Cancer Center - East Norriton Hospital Outpatient Center

    East Norriton, Pennsylvania, 19401, United States

  • Franciscan Health Indianapolis

    Indianapolis, Indiana, 46237, United States

  • Franciscan Health Mooresville

    Mooresville, Indiana, 46158, United States

  • Froedtert Menomonee Falls Hospital

    Menomonee Falls, Wisconsin, 53051, United States

  • Froedtert West Bend Hospital/Kraemer Cancer Center

    West Bend, Wisconsin, 53095, United States

  • Geauga Hospital

    Chardon, Ohio, 44024, United States

  • Genesee Cancer and Blood Disease Treatment Center

    Flint, Michigan, 48503, United States

  • Genesee Hematology Oncology PC

    Flint, Michigan, 48503, United States

  • Genesis Cancer Care Institute

    Davenport, Iowa, 52804, United States

  • Genesis Cancer Center - Silvis

    Silvis, Illinois, 61282, United States

  • Genesis Healthcare System Cancer Care Center

    Zanesville, Ohio, 43701, United States

  • Genesis Medical Center - East Campus

    Davenport, Iowa, 52803, United States

  • Genesys Hurley Cancer Institute

    Flint, Michigan, 48503, United States

  • Goshen Center for Cancer Care

    Goshen, Indiana, 46526, United States

  • Grant Medical Center

    Columbus, Ohio, 43215, United States

  • Greater Regional Medical Center

    Creston, Iowa, 50801, United States

  • Gundersen Lutheran Medical Center

    La Crosse, Wisconsin, 54601, United States

  • Harold Alfond Center for Cancer Care

    Augusta, Maine, 04330, United States

  • Hartford Hospital

    Hartford, Connecticut, 06102, United States

  • Hawaii Cancer Care - Savio

    ‘Aiea, Hawaii, 96701, United States

  • Hawaii Cancer Care Inc-POB II

    Honolulu, Hawaii, 96813, United States

  • HaysMed University of Kansas Health System

    Hays, Kansas, 67601, United States

  • Henry Ford Hospital

    Detroit, Michigan, 48202, United States

  • Henry Ford Macomb Hospital-Clinton Township

    Clinton Township, Michigan, 48038, United States

  • Hope Cancer Clinic

    Livonia, Michigan, 48154, United States

  • IHA Hematology Oncology Consultants-Ann Arbor

    Ypsilanti, Michigan, 48197, United States

  • IHA Hematology Oncology Consultants-Brighton

    Brighton, Michigan, 48114, United States

  • IHA Hematology Oncology Consultants-Canton

    Canton, Michigan, 48188, United States

  • IHA Hematology Oncology Consultants-Chelsea

    Chelsea, Michigan, 48118, United States

  • Illinois CancerCare-Bloomington

    Bloomington, Illinois, 61704, United States

  • Illinois CancerCare-Canton

    Canton, Illinois, 61520, United States

  • Illinois CancerCare-Carthage

    Carthage, Illinois, 62321, United States

  • Illinois CancerCare-Dixon

    Dixon, Illinois, 61021, United States

  • Illinois CancerCare-Eureka

    Eureka, Illinois, 61530, United States

  • Illinois CancerCare-Galesburg

    Galesburg, Illinois, 61401, United States

  • Illinois CancerCare-Kewanee Clinic

    Kewanee, Illinois, 61443, United States

  • Illinois CancerCare-Macomb

    Macomb, Illinois, 61455, United States

  • Illinois CancerCare-Ottawa Clinic

    Ottawa, Illinois, 61350, United States

  • Illinois CancerCare-Pekin

    Pekin, Illinois, 61554, United States

  • Illinois CancerCare-Peoria

    Peoria, Illinois, 61615, United States

  • Illinois CancerCare-Peru

    Peru, Illinois, 61354, United States

  • Illinois CancerCare-Princeton

    Princeton, Illinois, 61356, United States

  • Iowa Cancer Specialists

    Davenport, Iowa, 52807, United States

  • James J Peters VA Medical Center

    The Bronx, New York, 10468, United States

  • Jefferson Healthcare

    Port Townsend, Washington, 98368, United States

  • Kaiser Permanente - Harbor City

    Harbor City, California, 90710, United States

  • Kaiser Permanente - Panorama City

    Panorama City, California, 91402, United States

  • Kaiser Permanente Los Angeles Medical Center

    Los Angeles, California, 90027, United States

  • Kaiser Permanente Northwest

    Portland, Oregon, 97227, United States

  • Kaiser Permanente-Anaheim

    Anaheim, California, 92806, United States

  • Kaiser Permanente-Baldwin Park

    Baldwin Park, California, 91706, United States

  • Kaiser Permanente-Bellflower

    Bellflower, California, 90706, United States

  • Kaiser Permanente-Cadillac

    Los Angeles, California, 90034, United States

  • Kaiser Permanente-Fontana

    Fontana, California, 92335, United States

  • Kaiser Permanente-Irvine

    Irvine, California, 92618, United States

  • Kaiser Permanente-Ontario

    Ontario, California, 91761, United States

  • Kaiser Permanente-Riverside

    Riverside, California, 92505, United States

  • Kaiser Permanente-San Diego Zion

    San Diego, California, 92120, United States

  • Kaiser Permanente-San Marcos

    San Marcos, California, 92078, United States

  • Kaiser Permanente-Woodland Hills

    Woodland Hills, California, 91367, United States

  • Langlade Hospital and Cancer Center

    Antigo, Wisconsin, 54409, United States

  • Lewis Cancer and Research Pavilion at Saint Joseph's/Candler

    Savannah, Georgia, 31405, United States

  • Licking Memorial Hospital

    Newark, Ohio, 43055, United States

  • Loma Linda University Medical Center

    Loma Linda, California, 92354, United States

  • Loyola University Medical Center

    Maywood, Illinois, 60153, United States

  • Maine Medical Partners - South Portland

    South Portland, Maine, 04106, United States

  • MaineHealth/SMHC Cancer Care and Blood Disorders-Biddeford

    Biddeford, Maine, 04005, United States

  • MaineHealth/SMHC Cancer Care and Blood Disorders-Sanford

    Sanford, Maine, 04073, United States

  • Margaret R Pardee Memorial Hospital

    Hendersonville, North Carolina, 28791, United States

  • Marie Yeager Cancer Center

    Saint Joseph, Michigan, 49085, United States

  • Marietta Memorial Hospital

    Marietta, Ohio, 45750, United States

  • Marshfield Clinic - Weston Center

    Weston, Wisconsin, 54476, United States

  • Mary Greeley Medical Center

    Ames, Iowa, 50010, United States

  • Mary Imogene Bassett Hospital

    Cooperstown, New York, 13326, United States

  • McFarland Clinic PC - Ames

    Ames, Iowa, 50010, United States

  • McFarland Clinic PC-Boone

    Boone, Iowa, 50036, United States

  • McFarland Clinic PC-Jefferson

    Jefferson, Iowa, 50129, United States

  • McFarland Clinic PC-Marshalltown

    Marshalltown, Iowa, 50158, United States

  • McFarland Clinic PC-Trinity Cancer Center

    Fort Dodge, Iowa, 50501, United States

  • McKee Medical Center

    Loveland, Colorado, 80539, United States

  • Medical Center of Baton Rouge

    Baton Rouge, Louisiana, 70816, United States

  • Medical Center of the Rockies

    Loveland, Colorado, 80538, United States

  • Medical College of Wisconsin

    Milwaukee, Wisconsin, 53226, United States

  • Medical Oncology and Hematology Associates-Laurel

    Des Moines, Iowa, 50314, United States

  • Medical Oncology and Hematology Associates-West Des Moines

    Clive, Iowa, 50325, United States

  • Medical University of South Carolina

    Charleston, South Carolina, 29425, United States

  • Memorial Hospital North

    Colorado Springs, Colorado, 80920, United States

  • Memorial Hospital of South Bend

    South Bend, Indiana, 46601, United States

  • Mercy Cancer Center-West Lakes

    Clive, Iowa, 50325, United States

  • Mercy Hospital Oklahoma City

    Oklahoma City, Oklahoma, 73120, United States

  • Mercy Hospital Saint Louis

    St Louis, Missouri, 63141, United States

  • Mercy Hospital South

    St Louis, Missouri, 63128, United States

  • Mercy Hospital Springfield

    Springfield, Missouri, 65804, United States

  • Mercy Medical Center - Des Moines

    Des Moines, Iowa, 50314, United States

  • Mercy Medical Center-West Lakes

    West Des Moines, Iowa, 50266, United States

  • Metro Health Hospital

    Wyoming, Michigan, 49519, United States

  • Minneapolis VA Medical Center

    Minneapolis, Minnesota, 55417, United States

  • Missouri Baptist Medical Center

    St Louis, Missouri, 63131, United States

  • Missouri Baptist Outpatient Center-Sunset Hills

    Sunset Hills, Missouri, 63127, United States

  • Missouri Baptist Sullivan Hospital

    Sullivan, Missouri, 63080, United States

  • Moffitt Cancer Center

    Tampa, Florida, 33612, United States

  • Mount Sinai Comprehensive Cancer Center at Aventura

    Aventura, Florida, 33180, United States

  • Mount Sinai Medical Center

    Miami Beach, Florida, 33140, United States

  • Munson Medical Center

    Traverse City, Michigan, 49684, United States

  • New Hampshire Oncology Hematology PA-Concord

    Concord, New Hampshire, 03301, United States

  • New Mexico Oncology Hematology Consultants

    Albuquerque, New Mexico, 87109, United States

  • North Colorado Medical Center

    Greeley, Colorado, 80631, United States

  • NorthShore University HealthSystem-Evanston Hospital

    Evanston, Illinois, 60201, United States

  • NorthShore University HealthSystem-Glenbrook Hospital

    Glenview, Illinois, 60026, United States

  • NorthShore University HealthSystem-Highland Park Hospital

    Highland Park, Illinois, 60035, United States

  • Northeast Georgia Medical Center Braselton

    Braselton, Georgia, 30517, United States

  • Northeast Georgia Medical Center-Gainesville

    Gainesville, Georgia, 30501, United States

  • Northside Hospital

    Atlanta, Georgia, 30342, United States

  • Northside Hospital - Duluth

    Duluth, Georgia, 30096, United States

  • Northside Hospital - Gwinnett

    Lawrenceville, Georgia, 30046, United States

  • Northwestern University

    Chicago, Illinois, 60611, United States

  • Ochsner High Grove

    Baton Rouge, Louisiana, 70836, United States

  • Ochsner Medical Center Jefferson

    New Orleans, Louisiana, 70121, United States

  • Ochsner Medical Center Kenner

    Kenner, Louisiana, 70065, United States

  • OhioHealth Marion General Hospital

    Marion, Ohio, 43302, United States

  • Olathe Health Cancer Center

    Olathe, Kansas, 66061, United States

  • Oncology Hematology Associates of Saginaw Valley PC

    Saginaw, Michigan, 48604, United States

  • OptumCare Cancer Care at Fort Apache

    Las Vegas, Nevada, 89148, United States

  • OptumCare Cancer Care at Oakey

    Las Vegas, Nevada, 89102, United States

  • Oregon Health and Science University

    Portland, Oregon, 97239, United States

  • Pali Momi Medical Center

    ‘Aiea, Hawaii, 96701, United States

  • Palo Alto Medical Foundation Health Care

    Palo Alto, California, 94301, United States

  • Palo Alto Medical Foundation-Camino Division

    Mountain View, California, 94040, United States

  • Palo Alto Medical Foundation-Fremont

    Fremont, California, 94538, United States

  • Palo Alto Medical Foundation-Santa Cruz

    Santa Cruz, California, 95065, United States

  • Palo Alto Medical Foundation-Sunnyvale

    Sunnyvale, California, 94086, United States

  • Parkland Health Center - Farmington

    Farmington, Missouri, 63640, United States

  • Parkland Memorial Hospital

    Dallas, Texas, 75235, United States

  • Parkview Regional Medical Center

    Fort Wayne, Indiana, 46845, United States

  • Penobscot Bay Medical Center

    Rockport, Maine, 04856, United States

  • Pottstown Hospital

    Pottstown, Pennsylvania, 19464, United States

  • Poudre Valley Hospital

    Fort Collins, Colorado, 80524, United States

  • Presbyterian Intercommunity Hospital

    Whittier, California, 90602, United States

  • Presbyterian Kaseman Hospital

    Albuquerque, New Mexico, 87110, United States

  • Presbyterian Rust Medical Center/Jorgensen Cancer Center

    Rio Rancho, New Mexico, 87124, United States

  • Prisma Health Cancer Institute - Butternut

    Greenville, South Carolina, 29605, United States

  • Prisma Health Cancer Institute - Easley

    Easley, South Carolina, 29640, United States

  • Prisma Health Cancer Institute - Eastside

    Greenville, South Carolina, 29615, United States

  • Prisma Health Cancer Institute - Faris

    Greenville, South Carolina, 29605, United States

  • Prisma Health Cancer Institute - Greer

    Greer, South Carolina, 29650, United States

  • Prisma Health Cancer Institute - Seneca

    Seneca, South Carolina, 29672, United States

  • Prisma Health Cancer Institute - Spartanburg

    Spartanburg, South Carolina, 29307, United States

  • ProMedica Flower Hospital

    Sylvania, Ohio, 43560, United States

  • Queen's Cancer Cenrer - POB I

    Honolulu, Hawaii, 96813, United States

  • Queen's Cancer Center - Kuakini

    Honolulu, Hawaii, 96817, United States

  • Queen's Medical Center

    Honolulu, Hawaii, 96813, United States

  • Randolph Hospital

    Asheboro, North Carolina, 27203, United States

  • Renown Regional Medical Center

    Reno, Nevada, 89502, United States

  • Rex Cancer Center

    Raleigh, North Carolina, 27607, United States

  • Rex Cancer Center of Wakefield

    Raleigh, North Carolina, 27614, United States

  • Rex Hematology Oncology Associates-Blue Ridge

    Raleigh, North Carolina, 27607, United States

  • Rex Hematology Oncology Associates-Cary

    Cary, North Carolina, 27518, United States

  • Rex Hematology Oncology Associates-Garner

    Garner, North Carolina, 27529, United States

  • Rocky Mountain Cancer Centers-Boulder

    Boulder, Colorado, 80304, United States

  • Rocky Mountain Cancer Centers-Littleton

    Littleton, Colorado, 80120, United States

  • Rocky Mountain Cancer Centers-Midtown

    Denver, Colorado, 80218, United States

  • Rocky Mountain Cancer Centers-Sky Ridge

    Lone Tree, Colorado, 80124, United States

  • Saint Francis Medical Center

    Cape Girardeau, Missouri, 63703, United States

  • Saint Joseph Mercy Brighton

    Brighton, Michigan, 48114, United States

  • Saint Joseph Mercy Canton

    Canton, Michigan, 48188, United States

  • Saint Joseph Mercy Chelsea

    Chelsea, Michigan, 48118, United States

  • Saint Joseph Mercy Hospital

    Ann Arbor, Michigan, 48106, United States

  • Saint Luke's Cancer Institute - Fruitland

    Fruitland, Idaho, 83619, United States

  • Saint Luke's Cancer Institute - Meridian

    Meridian, Idaho, 83642, United States

  • Saint Luke's Cancer Institute - Nampa

    Nampa, Idaho, 83686, United States

  • Saint Luke's Cancer Institute - Twin Falls

    Twin Falls, Idaho, 83301, United States

  • Saint Luke's Mountain States Tumor Institute

    Boise, Idaho, 83712, United States

  • Saint Mary Mercy Hospital

    Livonia, Michigan, 48154, United States

  • Sainte Genevieve County Memorial Hospital

    Sainte Genevieve, Missouri, 63670, United States

  • Salem Hospital

    Salem, Oregon, 97301, United States

  • Salina Regional Health Center

    Salina, Kansas, 67401, United States

  • Sanford Bismarck Medical Center

    Bismarck, North Dakota, 58501, United States

  • Sanford Broadway Medical Center

    Fargo, North Dakota, 58122, United States

  • Sanford Cancer Center Oncology Clinic

    Sioux Falls, South Dakota, 57104, United States

  • Sanford Joe Lueken Cancer Center

    Bemidji, Minnesota, 56601, United States

  • Sanford Roger Maris Cancer Center

    Fargo, North Dakota, 58122, United States

  • Sanford USD Medical Center - Sioux Falls

    Sioux Falls, South Dakota, 57117-5134, United States

  • Sechler Family Cancer Center

    Lebanon, Pennsylvania, 17042, United States

  • Siteman Cancer Center at Saint Peters Hospital

    City of Saint Peters, Missouri, 63376, United States

  • Siteman Cancer Center at West County Hospital

    Creve Coeur, Missouri, 63141, United States

  • Siteman Cancer Center-South County

    St Louis, Missouri, 63129, United States

  • Solinsky Center for Cancer Care

    Manchester, New Hampshire, 03103, United States

  • Southern Ohio Medical Center

    Portsmouth, Ohio, 45662, United States

  • Sparrow Hospital

    Lansing, Michigan, 48912, United States

  • Spectrum Health Reed City Hospital

    Reed City, Michigan, 49677, United States

  • Spectrum Health at Butterworth Campus

    Grand Rapids, Michigan, 49503, United States

  • Stanford Cancer Institute Palo Alto

    Palo Alto, California, 94304, United States

  • Straub Clinic and Hospital

    Honolulu, Hawaii, 96813, United States

  • Strecker Cancer Center-Belpre

    Belpre, Ohio, 45714, United States

  • Suburban Hematology Oncology Associates - Snellville

    Snellville, Georgia, 30078, United States

  • Sutter Auburn Faith Hospital

    Auburn, California, 95602, United States

  • Sutter Medical Center Sacramento

    Sacramento, California, 95816, United States

  • Sutter Roseville Medical Center

    Roseville, California, 95661, United States

  • Sutter Solano Medical Center/Cancer Center

    Vallejo, California, 94589, United States

  • Temple University Hospital

    Philadelphia, Pennsylvania, 19140, United States

  • The Don and Sybil Harrington Cancer Center

    Amarillo, Texas, 79106, United States

  • The Mark H Zangmeister Center

    Columbus, Ohio, 43219, United States

  • Thomas Jefferson University Hospital

    Philadelphia, Pennsylvania, 19107, United States

  • Truman Medical Centers

    Kansas City, Missouri, 64108, United States

  • UCHealth Greeley Hospital

    Greeley, Colorado, 80631, United States

  • UCHealth Highlands Ranch Hospital

    Highlands Ranch, Colorado, 80129, United States

  • UCHealth Lone Tree Health Center

    Lone Tree, Colorado, 80124, United States

  • UCHealth Memorial Hospital Central

    Colorado Springs, Colorado, 80909, United States

  • UH Seidman Cancer Center at Firelands Regional Medical Center

    Sandusky, Ohio, 44870, United States

  • UH Seidman Cancer Center at Lake Health Mentor Campus

    Mentor, Ohio, 44060, United States

  • UH Seidman Cancer Center at Landerbrook Health Center

    Mayfield Heights, Ohio, 44124, United States

  • UH Seidman Cancer Center at Saint John Medical Center

    Westlake, Ohio, 44145, United States

  • UH Seidman Cancer Center at Southwest General Hospital

    Middleburg Heights, Ohio, 44130, United States

  • UHHS-Chagrin Highlands Medical Center

    Beachwood, Ohio, 44122, United States

  • UHHS-Westlake Medical Center

    Westlake, Ohio, 44145, United States

  • UMass Memorial Medical Center - University Campus

    Worcester, Massachusetts, 01655, United States

  • UPMC Pinnacle Cancer Center/Community Osteopathic Campus

    Harrisburg, Pennsylvania, 17109, United States

  • UPMC Susquehanna

    Williamsport, Pennsylvania, 17701, United States

  • UT Southwestern/Simmons Cancer Center-Dallas

    Dallas, Texas, 75390, United States

  • United Hospital

    Saint Paul, Minnesota, 55102, United States

  • University Hospitals Parma Medical Center

    Parma, Ohio, 44129, United States

  • University Hospitals Portage Medical Center

    Ravenna, Ohio, 44266, United States

  • University Hospitals Sharon Health Center

    Wadsworth, Ohio, 44281, United States

  • University of Arkansas for Medical Sciences

    Little Rock, Arkansas, 72205, United States

  • University of California Davis Comprehensive Cancer Center

    Sacramento, California, 95817, United States

  • University of Colorado Hospital

    Aurora, Colorado, 80045, United States

  • University of Kansas Cancer Center

    Kansas City, Kansas, 66160, United States

  • University of Kansas Cancer Center - Lee's Summit

    Lee's Summit, Missouri, 64064, United States

  • University of Kansas Cancer Center - North

    Kansas City, Missouri, 64154, United States

  • University of Kansas Cancer Center at North Kansas City Hospital

    North Kansas City, Missouri, 64116, United States

  • University of Kansas Cancer Center-Overland Park

    Overland Park, Kansas, 66210, United States

  • University of Kansas Health System Saint Francis Campus

    Topeka, Kansas, 66606, United States

  • University of Kansas Hospital-Westwood Cancer Center

    Westwood, Kansas, 66205, United States

  • University of Kentucky/Markey Cancer Center

    Lexington, Kentucky, 40536, United States

  • University of Mississippi Medical Center

    Jackson, Mississippi, 39216, United States

  • University of New Mexico Cancer Center

    Albuquerque, New Mexico, 87102, United States

  • University of Oklahoma Health Sciences Center

    Oklahoma City, Oklahoma, 73104, United States

  • University of Pittsburgh Cancer Institute (UPCI)

    Pittsburgh, Pennsylvania, 15232, United States

  • University of Rochester

    Rochester, New York, 14642, United States

  • Veterans Affairs Connecticut Healthcare System-West Haven Campus

    West Haven, Connecticut, 06516, United States

  • Vince Lombardi Cancer Clinic - Oshkosh

    Oshkosh, Wisconsin, 54904, United States

  • Vince Lombardi Cancer Clinic-Sheboygan

    Sheboygan, Wisconsin, 53081, United States

  • Vince Lombardi Cancer Clinic-Two Rivers

    Two Rivers, Wisconsin, 54241, United States

  • Virtua Samson Cancer Center

    Moorestown, New Jersey, 08057, United States

  • Virtua Voorhees

    Voorhees Township, New Jersey, 08043, United States

  • Waldo County General Hospital

    Belfast, Maine, 04915, United States

  • Washington University School of Medicine

    St Louis, Missouri, 63110, United States

  • WellSpan Health-York Cancer Center

    York, Pennsylvania, 17403, United States

  • West Michigan Cancer Center

    Kalamazoo, Michigan, 49007, United States

  • Western Maryland Regional Medical Center

    Cumberland, Maryland, 21502, United States

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