STAGE IVA LUNG CANCER AJCC V8

This early-stage trial tests a new drug (MRX-2843) combined with a standard treatment (osimertinib) for people with advanced EGFR-mutant non-small cell lung cancer. The goal is to find the safest and most effective dose and to see how well the combination works. About 69 particip…

This early-phase trial is testing a new drug called PBF-1129 combined with the immunotherapy nivolumab in people with advanced non-small cell lung cancer that has returned or spread. The main goal is to find the safest dose and understand side effects. About 30 adults who have al…

This early-phase study tests whether adding low-dose IL-2 to the immunotherapy drug pembrolizumab can strengthen the immune system's attack on advanced lung cancer. About 15 people with untreated stage IV non-small cell lung cancer will receive the combination. The main goal is t…

This study tests a personalized vaccine made from a patient's own tumor proteins, combined with the immunotherapy drug pembrolizumab, for people with advanced solid tumors (like breast, lung, or skin cancer). The goal is to see if the combination is safe and helps the immune syst…

This early-phase study tests a combination of two drugs, osimertinib and tegavivint, as the first treatment for people with a specific type of advanced lung cancer (EGFR-mutant NSCLC that has spread). The main goal is to find the safest dose and see how well the drugs work togeth…

This study tests a combination of chemotherapy (temozolomide) and immunotherapy (atezolizumab) as a second or third treatment option for people with small cell lung cancer that has spread or returned. The goal is to see if this combination can shrink tumors and help patients live…

This study tests a drug called avapritinib in people with advanced solid tumors that have spread and have specific gene changes (CKIT or PDGFRA mutations). The drug works by blocking enzymes that help cancer cells grow. The goal is to see if avapritinib can shrink or control thes…

This study tests a dye called panitumumab-IRDye800 that attaches to lung cancer cells and makes them glow under a special camera during surgery. The goal is to help surgeons see and remove all cancer tissue more accurately. About 30 adults with lung cancer or lung metastases will…

This study tests a smarter way to give radiation to people with lung cancer. Normally, the radiation plan is made before treatment starts, but tumors can shrink during treatment, which may expose healthy tissue to unnecessary radiation. In this study, the radiation plan is update…

This study tests whether a special yoga program can improve physical function, fatigue, sleep, and quality of life for people with lung or esophageal cancer who are getting radiation therapy, and also for their family caregivers. About 400 patient-caregiver pairs will take part. …

This study looks at how the bacteria in your gut might influence stomach issues like diarrhea and colitis caused by certain cancer drugs (immune checkpoint inhibitors). Researchers will collect stool, blood, and tissue samples from 800 people with melanoma, lung cancer, or genito…