New drug combo aims to boost immune system against tough lung cancer

NCT ID NCT05096663

Ongoing Disease control Sponsor: SWOG Cancer Research Network Source: ClinicalTrials.gov ↗

First seen May 21, 2026 · Last updated May 23, 2026 · Updated 1 time

Summary

This study tests whether adding an experimental drug (N-803) to the immunotherapy pembrolizumab works better than standard treatments for people with advanced non-small cell lung cancer that has already been treated with other immunotherapies. N-803 activates natural killer cells, while pembrolizumab helps the immune system attack cancer cells. About 82 participants will be enrolled to see if the combo improves survival and shrinks tumors.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Abbott-Northwestern Hospital

Minneapolis, Minnesota, 55407, United States
Academic Hematology Oncology Specialists

Grosse Pointe Woods, Michigan, 48236, United States
Adams Cancer Center

Gettysburg, Pennsylvania, 17325, United States
Addison Gilbert Hospital

Gloucester, Massachusetts, 01930, United States
Adena Regional Medical Center

Chillicothe, Ohio, 45601, United States
AdventHealth Hendersonville

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AdventHealth Infusion Center Asheville

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Mebane, North Carolina, 27302, United States
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Effingham, Illinois, 62401, United States
Dartmouth Hitchcock Medical Center

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Delaware Health Center-Grady Cancer Center

Delaware, Ohio, 43015, United States
Divine Providence Hospital

Williamsport, Pennsylvania, 17754, United States
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Columbus, Ohio, 43228, United States
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Raleigh, North Carolina, 27609, United States
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Durham, North Carolina, 27710, United States
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Essentia Health - Deer River Clinic

Deer River, Minnesota, 56636, United States
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Essentia Health Hibbing Clinic

Hibbing, Minnesota, 55746, United States
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Sandstone, Minnesota, 55072, United States
Essentia Health Virginia Clinic

Virginia, Minnesota, 55792, United States
FirstHealth of the Carolinas-Moore Regional Hospital

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Fox Chase Cancer Center

Philadelphia, Pennsylvania, 19111, United States
Froedtert Menomonee Falls Hospital

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Genesee Cancer and Blood Disease Treatment Center

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West Islip, New York, 11795, United States
Grant Medical Center

Columbus, Ohio, 43215, United States
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East China Township, Michigan, 48054, United States
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Macomb, Michigan, 48044, United States
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Harold Alfond Center for Cancer Care

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Indiana University/Melvin and Bren Simon Cancer Center

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Kaiser Permanente - Harbor City

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Washington D.C., District of Columbia, 20002, United States
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Knox Community Hospital

Mount Vernon, Ohio, 43050, United States
Lafayette Family Cancer Center-EMMC

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Lahey Hospital and Medical Center

Burlington, Massachusetts, 01805, United States
Lahey Medical Center-Peabody

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Lawrence Memorial Hospital

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Lewis Cancer and Research Pavilion at Saint Joseph's/Candler

Savannah, Georgia, 31405, United States
Licking Memorial Hospital

Newark, Ohio, 43055, United States
Louisiana Hematology Oncology Associates LLC

Baton Rouge, Louisiana, 70809, United States
MaineHealth/SMHC Cancer Care and Blood Disorders-Biddeford

Biddeford, Maine, 04005, United States
MaineHealth/SMHC Cancer Care and Blood Disorders-Sanford

Sanford, Maine, 04073, United States
Marie Yeager Cancer Center

Saint Joseph, Michigan, 49085, United States
Mary Greeley Medical Center

Ames, Iowa, 50010, United States
Mary Imogene Bassett Hospital

Cooperstown, New York, 13326, United States
McFarland Clinic PC - Ames

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Marshalltown, Iowa, 50158, United States
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Fort Dodge, Iowa, 50501, United States
Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States
Medical Oncology Hematology Consultants PA

Newark, Delaware, 19713, United States
Medical Oncology and Hematology Associates-West Des Moines

Clive, Iowa, 50325, United States
Medical University of South Carolina

Charleston, South Carolina, 29425, United States
Memorial Hospital of South Bend

South Bend, Indiana, 46601, United States
Memorial Medical Center

Modesto, California, 95355, United States
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Springfield, Illinois, 62781, United States
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Mercy Cancer Center-West Lakes

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Mercyhealth Javon Bea Hospital - Rockton

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Minneapolis VA Medical Center

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Mission Cancer and Blood - Laurel

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Missouri Baptist Medical Center

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Chicago, Illinois, 60611, United States
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Marion, Ohio, 43302, United States
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Prisma Health Cancer Institute - Butternut

Greenville, South Carolina, 29605, United States
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Easley, South Carolina, 29640, United States
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Greenville, South Carolina, 29615, United States
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Greenville, South Carolina, 29605, United States
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Greer, South Carolina, 29650, United States
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Seneca, South Carolina, 29672, United States
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Boiling Springs, South Carolina, 29316, United States
Prisma Health Greenville Memorial Hospital

Greenville, South Carolina, 29605, United States
ProMedica Flower Hospital

Sylvania, Ohio, 43560, United States
Ralph H Johnson VA Medical Center

Charleston, South Carolina, 29401, United States
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Asheboro, North Carolina, 27203, United States
Regions Hospital

Saint Paul, Minnesota, 55101, United States
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Reno, Nevada, 89502, United States
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Columbus, Ohio, 43214, United States
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Boise, Idaho, 83706, United States
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Westerville, Ohio, 43081, United States
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Cape Girardeau, Missouri, 63703, United States
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Warren, Michigan, 48093, United States
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Canton, Michigan, 48188, United States
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Chelsea, Michigan, 48118, United States
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Ann Arbor, Michigan, 48106, United States
Saint Luke's Cancer Institute - Boise

Boise, Idaho, 83712, United States
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Fruitland, Idaho, 83619, United States
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Meridian, Idaho, 83642, United States
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Nampa, Idaho, 83686, United States
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Twin Falls, Idaho, 83301, United States
Saint Vincent Hospital Cancer Center Green Bay

Green Bay, Wisconsin, 54301, United States
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Oconto Falls, Wisconsin, 54154, United States
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Green Bay, Wisconsin, 54303, United States
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Sturgeon Bay, Wisconsin, 54235-1495, United States
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Sainte Genevieve, Missouri, 63670, United States
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Salina, Kansas, 67401, United States
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Bismarck, North Dakota, 58501, United States
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Fargo, North Dakota, 58122, United States
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Sioux Falls, South Dakota, 57104, United States
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Bemidji, Minnesota, 56601, United States
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Fargo, North Dakota, 58122, United States
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Sioux Falls, South Dakota, 57117-5134, United States
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Lebanon, Pennsylvania, 17042, United States
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St Louis, Missouri, 63136, United States
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City of Saint Peters, Missouri, 63376, United States
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Creve Coeur, Missouri, 63141, United States
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St Louis, Missouri, 63129, United States
Solinsky Center for Cancer Care

Manchester, New Hampshire, 03103, United States
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Warrensville Heights, Ohio, 44122, United States
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Springfield, Illinois, 62702, United States
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Portsmouth, Ohio, 45662, United States
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Lansing, Michigan, 48912, United States
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Springfield, Illinois, 62702, United States
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Springfield, Ohio, 45504, United States
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Springfield, Ohio, 45505, United States
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Belpre, Ohio, 45714, United States
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Auburn, California, 95602, United States
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Roseville, California, 95661, United States
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Vallejo, California, 94589, United States
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Urbana, Illinois, 61801, United States
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Amarillo, Texas, 79106, United States
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Columbus, Ohio, 43219, United States
Torrance Memorial Physician Network - Cancer Care

Torrance, California, 90505, United States
Tower Cancer Research Foundation

Beverly Hills, California, 90211, United States
Trinity Health IHA Medical Group Hematology Oncology - Brighton

Brighton, Michigan, 48114, United States
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Canton, Michigan, 48188, United States
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Chelsea, Michigan, 48118, United States
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Ypsilanti, Michigan, 48197, United States
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Livonia, Michigan, 48154, United States
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Steubenville, Ohio, 43952, United States
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Cranberry Township, Pennsylvania, 16066, United States
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Erie, Pennsylvania, 16505, United States
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Butler, Pennsylvania, 16001, United States
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Johnstown, Pennsylvania, 15901, United States
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Pittsburgh, Pennsylvania, 15237, United States
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Fort Worth, Texas, 76104, United States
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Little Rock, Arkansas, 72205, United States
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Sacramento, California, 95817, United States
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Bettendorf, Iowa, 52722, United States
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North Kansas City, Missouri, 64116, United States
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Overland Park, Kansas, 66210, United States
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Topeka, Kansas, 66606, United States
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Overland Park, Kansas, 66211, United States
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Westwood, Kansas, 66205, United States
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Lexington, Kentucky, 40536, United States
University of Michigan Comprehensive Cancer Center

Ann Arbor, Michigan, 48109, United States
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Jackson, Mississippi, 39216, United States
University of New Mexico Cancer Center

Albuquerque, New Mexico, 87102, United States
University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104, United States
University of Pittsburgh Cancer Institute (UPCI)

Pittsburgh, Pennsylvania, 15232, United States
University of Rochester

Rochester, New York, 14642, United States
University of Wisconsin Carbone Cancer Center

Madison, Wisconsin, 53792, United States
Veterans Administration Medical Center - Birmingham

Birmingham, Alabama, 35233, United States
Veterans Affairs Connecticut Healthcare System-West Haven Campus

West Haven, Connecticut, 06516, United States
Veterans Affairs Medical Center - San Francisco

San Francisco, California, 94121, United States
Virtua Samson Cancer Center

Moorestown, New Jersey, 08057, United States
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Voorhees Township, New Jersey, 08043, United States
Washington University School of Medicine

St Louis, Missouri, 63110, United States
WellSpan Health-York Cancer Center

York, Pennsylvania, 17403, United States
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York, Pennsylvania, 17403, United States
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Chambersburg, Pennsylvania, 17201, United States
West Michigan Cancer Center

Kalamazoo, Michigan, 49007, United States
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Charleston, West Virginia, 25304, United States
West Virginia University Healthcare

Morgantown, West Virginia, 26506, United States
William E Kahlert Regional Cancer Center/Sinai Hospital

Westminster, Maryland, 21157, United States

Conditions

Explore the condition pages connected to this study.

ADVANCED LUNG NON-SMALL CELL CARCINOMA RECURRENT LUNG NON-SMALL CELL CARCINOMA STAGE III LUNG CANCER AJCC V8 STAGE IIIA LUNG CANCER AJCC V8 STAGE IIIB LUNG CANCER AJCC V8 STAGE IIIC LUNG CANCER AJCC V8 STAGE IV LUNG CANCER AJCC V8 STAGE IVA LUNG CANCER AJCC V8 STAGE IVB LUNG CANCER AJCC V8