STAGE IVA LUNG CANCER AJCC V8

This phase II trial is testing whether combining the chemotherapy drug temozolomide with the immunotherapy atezolizumab can help shrink tumors or slow the disease in people with advanced small cell lung cancer that has spread or returned. About 56 participants will receive the co…

This study tests a personalized vaccine made from a patient's own tumor proteins, combined with the immunotherapy drug pembrolizumab, for people with advanced solid tumors. The goal is to see if the combination is safe and helps the immune system fight cancer more effectively. Ab…

This early-phase trial tests whether adding low-dose interleukin-2 (IL-2) to the immunotherapy drug pembrolizumab (Keytruda) can better activate the immune system against stage IV non-small cell lung cancer. The study will enroll 15 people who have not had prior treatment for the…

This early-phase study tests a combination of two drugs, osimertinib and tegavivint, as the first treatment for people with a certain type of advanced lung cancer (EGFR-mutant NSCLC that has spread). The main goal is to find the safest dose and see how well the drugs work togethe…

This early-stage trial tests a new drug called MRX-2843 combined with the standard targeted therapy osimertinib in people with advanced EGFR-mutant non-small cell lung cancer. The goal is to find the safest dose and see if the combination can stop tumor growth by blocking key enz…

This early-stage trial tests a new drug (PBF-1129) combined with an immunotherapy (nivolumab) in 30 adults with advanced non-small cell lung cancer that has returned or spread. The main goal is to find the safest dose and understand side effects. Participants must have already tr…

This study tests a drug called avapritinib in people with advanced solid tumors that have certain genetic changes (CKIT or PDGFRA mutations). The goal is to see if the drug can shrink or control the cancer. About 50 adults with cancers like melanoma, sarcoma, or breast, lung, or …

This study tests a special dye that attaches to lung cancer cells and makes them glow under a camera during surgery. The goal is to help surgeons see and remove all cancer tissue more accurately. About 30 adults with lung cancer or lung metastases will receive the dye before thei…

This study tests whether a special yoga program can improve physical function, fatigue, sleep, and quality of life for people with lung or esophageal cancer who are getting radiation therapy, as well as for their family caregivers. About 400 patient-caregiver pairs will take part…

This study looks at how the bacteria in your gut might cause stomach issues like diarrhea and colitis when you take certain cancer drugs called immune checkpoint inhibitors. Researchers will collect stool, blood, and tissue samples from 800 people with melanoma, lung cancer, or g…