STAGE IIIB LUNG CANCER AJCC V8

This large, late-stage trial is testing if adding a new oral drug (AZD6738) to an existing immunotherapy (durvalumab) works better than the immunotherapy alone to keep non-small cell lung cancer from coming back. It is for patients who have already had chemotherapy and surgery to…

This study is testing whether combining a cancer vaccine (CIMAvax) with immunotherapy drugs (nivolumab or pembrolizumab) is safe and effective for people with advanced non-small cell lung cancer or squamous head and neck cancer. The goal is to help the body's immune system better…

This large study is testing if starting an immunotherapy drug called durvalumab at the same time as standard chemotherapy and radiation is better than the current approach of giving it only after those treatments. It involves 660 adults with stage 3 non-small cell lung cancer tha…

This early-stage study is testing a new nanoparticle drug called NBTXR3 for people with inoperable, recurrent non-small cell lung cancer. The nanoparticle is injected directly into the tumor and is designed to make standard radiation therapy more powerful at killing cancer cells,…

This trial is testing a combination of three drugs (niraparib, temozolomide, and atezolizumab) to see if they work better together to control advanced cancers. The study first finds the safest dose, then compares the three-drug combo to a single drug for patients with extensive-s…

This study is for people with advanced non-small cell lung cancer that has a specific genetic change (EGFR mutation). It tests if taking the targeted drug osimertinib for 6-12 weeks, then adding focused radiation therapy or surgery to remaining tumors, works better at keeping the…

This study is for people with advanced non-small cell lung cancer that has low levels of a marker called PD-L1. It compares the standard immunotherapy treatment (with or without chemo) to the same treatment plus a short course of radiation. The goal is to see if adding radiation …

This study is testing whether a lung cancer immunotherapy drug can be safely and effectively given at home by a visiting nurse, with most doctor visits done remotely via video call. It involves patients with non-small cell lung cancer who are eligible for the drug atezolizumab. T…

This study is testing a new, faster way to give radiation after surgery for non-small cell lung cancer. Instead of weeks of daily treatments, doctors give one powerful, highly focused dose to try to kill any leftover cancer cells while aiming to spare healthy lung tissue. The mai…

This study is testing whether combining two drugs, niraparib and dostarlimab, can help control recurrent small cell lung cancer and other aggressive neuroendocrine cancers. It is for adults whose cancer has returned after at least one prior treatment. The goal is to see if this c…

This early-stage study is testing whether adding an experimental drug called minnelide to an existing lung cancer medication (osimertinib) is safe and might help patients whose cancer has continued to grow. The trial is for adults with advanced non-small cell lung cancer that has…

This study is comparing two standard ways to treat small lung tumors: a minimally invasive procedure that uses microwave energy to heat and destroy the tumor, and a small surgery to cut it out. Researchers want to see which method is safer, more effective at keeping the cancer fr…

This early-stage study is testing whether two immunotherapy drugs (ipilimumab and nivolumab) can be safely combined with radiation therapy for patients with stage II or III non-small cell lung cancer. The goal is to see if this combination helps the immune system attack the cance…

This study is testing if adding a new drug called pevonedistat to two standard chemotherapy drugs (carboplatin and paclitaxel) works better for people with advanced non-small cell lung cancer. It is for adults whose cancer has gotten worse after treatment with immunotherapy. The …

This early-stage study is testing a new type of cell therapy for people with advanced non-small cell lung cancer that has spread and no longer responds to standard immunotherapy. Researchers are giving patients specially modified immune cells (called NK cells) taken from umbilica…

This trial is testing whether adding a new drug called LY3295668 to an existing lung cancer drug (osimertinib) can help control cancer that has stopped responding to standard treatment. It involves 32 adults with a specific type of advanced lung cancer (EGFR-mutant non-small cell…

This study is testing a combination of two drugs, trametinib and pembrolizumab, for people with advanced non-small cell lung cancer that has come back or spread after previous treatments. The goal is to see if the drugs work better together to control the cancer and to find the s…

This large, late-stage trial aims to find the best way to combine immunotherapy and chemotherapy for patients with advanced non-squamous lung cancer. It will compare starting with immunotherapy alone versus starting with both treatments together, and test different approaches if …

This study is testing a combination of three immunotherapy drugs—tocilizumab, ipilimumab, and nivolumab—in patients with advanced melanoma, non-small cell lung cancer, or bladder cancer. The main goal is to see if adding tocilizumab can help manage the serious side effects someti…

This early-phase study is testing a combination of two drugs, brigatinib and bevacizumab, for patients with a specific type of advanced lung cancer (ALK-positive) that has worsened despite prior targeted therapy. The main goals are to find the safest dose and understand the side …

This study is testing whether a drug called anamorelin can improve appetite and help stop weight loss in people with advanced non-small cell lung cancer. Participants will take either the drug or a placebo pill daily for nine weeks. Researchers will interview patients about their…

This study is testing whether a special program led by nurses can help people with advanced lung or gynecologic cancer cope with intense fears about their illness getting worse. Participants will have five short video sessions over six weeks to learn worry management skills, set …

This study is testing a telehealth program designed to help people who have finished treatment for early-stage lung or colorectal cancer. It compares a special coaching program that teaches self-management skills to standard educational materials. The goal is to see if the coachi…

This study is testing an online support program designed to help women with lung cancer feel better emotionally and manage their symptoms. Participants are assigned to either a group learning mindfulness and coping skills or a group receiving educational information about lung ca…

This study aims to create a tool to predict which cancer patients are most likely to develop nerve damage (like tingling or numbness in hands and feet) from a common class of chemotherapy drugs called taxanes. Researchers will follow over 1,300 patients with breast, lung, or ovar…

This large study aims to understand the genetic makeup of lung cancer tumors after they have been surgically removed. It will test tumor samples from 8,300 patients with early-stage non-small cell lung cancer to identify specific genetic changes. The goal is to use this genetic i…