RENAL IMPAIRMENT

This study looked at whether using a very small amount of contrast dye (less than 15 ml) is safe and works for opening blocked leg arteries in 18 patients who have both severe leg pain and kidney problems. The goal was to protect the kidneys while still successfully treating the …

This study followed 215 people newly diagnosed with HIV in Hong Kong to see how often they developed non-AIDS conditions like high blood pressure, diabetes, bone thinning, and kidney problems. Participants were checked before starting HIV treatment and again after 48 and 96 weeks…

This study looked at how the body handles a single dose of the experimental drug BMS-986278 in people with severe kidney problems or those on dialysis, compared to healthy volunteers. The goal was to understand safety and drug levels, not to treat the disease. 27 adults took part…

This study looked at how the tuberculosis drug pretomanid is handled by the body in people with different levels of kidney function. Twelve adults with kidney impairment and healthy volunteers took a single dose to compare drug levels and safety. The goal is to find the right dos…

This study looked at how different levels of kidney function affect the way the body processes a single dose of the drug ESK-001. Sixteen adults with healthy kidneys or mild, moderate, or severe kidney problems took part. Researchers measured drug levels in the blood and checked …

This study looked at how the drug resmetirom is processed in the body of people with severe kidney impairment compared to healthy people. 28 participants took 100 mg of resmetirom daily for 6 days. The goal was to measure drug levels and check for side effects, helping doctors un…

This study looked at how the drug MK-8527 is processed in people with moderate and severe kidney problems compared to healthy people. 18 adults took a single dose of the drug, and researchers measured drug levels in the blood over time. The goal was to understand how kidney impai…

This study tested a single dose of the drug olpasiran in 33 adults with normal kidney function or varying degrees of kidney impairment. The goal was to see how the body processes the drug and to check for safety. Results help doctors understand dosing for patients with kidney iss…

This study looked at how the body processes a single dose of the drug cenerimod in people with severe kidney impairment compared to healthy volunteers. A total of 16 adults took part. The goal was to measure drug levels and safety, not to treat any disease.

This study looked at how the weight-management drug petrelintide behaves in people with different levels of kidney function. Researchers compared 39 adults with normal kidneys to those with mild, moderate, or severe kidney impairment. The goal was to see if kidney problems change…

This study looked at how the drug LY3537031 enters the blood and leaves the body in people with different levels of kidney function. 31 adults, some with kidney impairment and some healthy, took a single dose. The goal was to gather safety and processing data, not to treat any co…

This study looked at how the drug AZD5462 moves through the body in people with kidney problems compared to healthy volunteers. Sixteen adults took a single dose, and researchers measured drug levels and checked for side effects. The goal was to understand how kidney function aff…

This study looked at how different levels of kidney function affect the amount of a new medicine (BI 456906) in the blood. The medicine is being developed for obesity and liver problems. 42 adults with or without kidney problems received a single injection. Researchers compared b…

This study tested a single dose of the drug AZD4144 in 41 adults with severe kidney disease, end-stage kidney disease, and healthy volunteers. Researchers measured how the drug moves through the body and checked for side effects. The goal was to understand how kidney problems aff…

This study tested whether a special type of MRI (multiparametric MRI) can reliably measure kidney function in people with metabolic syndrome—a cluster of conditions like obesity, high blood pressure, and high blood sugar. Researchers compared MRI results between 46 healthy volunt…

This study looked at how the drug MCI-186 is handled by the body in people with mild or moderate kidney problems compared to those with normal kidneys. Thirty adults received a single dose of the drug, and researchers measured its levels in the blood over time. The goal was to un…

This study tested how the drug AZD6234 moves through the body in people with different levels of kidney function, from mild to end-stage disease, compared to healthy volunteers. A total of 24 adults received a single injection of the drug. The goal was to see if kidney problems c…

This study looked at how different levels of kidney function affect the way the body handles a drug called enpatoran. 34 adults with normal or impaired kidneys received a single dose. Researchers measured drug levels in the blood and checked for side effects. The goal was to unde…

This study looked at how the drug BPN14770 is processed by the body in people with severe kidney impairment compared to healthy volunteers. Fourteen participants took a single dose, and researchers measured drug levels and checked for side effects. The goal was to understand if k…

This study looked at how the experimental drug MBX 2109 behaves in the body and whether it is safe for people with different levels of kidney function. Twenty-five adults with normal or impaired kidneys received a single injection of the drug. The goal was to measure drug levels …

This study looked at how the drug MK-1084 (calderasib) moves through the body in people with moderate or severe kidney problems compared to healthy people. Researchers measured drug levels in the blood over time and checked for side effects. The goal was to understand if kidney f…