Renal impairment

Doctors often see creatinine rise in patients taking vancomycin plus piperacillin-tazobactam, a common antibiotic pair. It is unclear whether that rise means real kidney injury or a harmless lab change. This study follows 304 adults on either that pair or vancomycin plus meropene…

This phase 1 trial examines how severe kidney impairment or end-stage kidney disease affects the levels of ribupatide, an experimental drug, after a single injection. Researchers compare drug exposure in 32 participants: some with normal kidney function and others with severe kid…

This trial is investigating how different levels of kidney function affect the way the body processes a single dose of the antibiotic afabicin. About 60 adults with varying degrees of kidney impairment, from mild to severe, will receive either an oral tablet or an intravenous inf…

This study looks at how the drug D-2570 moves through the body in people with reduced kidney function compared to those with normal kidneys. About 40 adults aged 18 to 70 will receive a single dose of D-2570. Researchers will measure drug levels in the blood and monitor for side …

This study looks at ICU patients with kidney failure who need blood thinners to prevent dangerous clots. Doctors currently use different types of heparin, but it's unclear which is safest and works best when kidneys are weak. The study will track over 1,100 patients to compare bl…

This study looks at whether kidney problems interfere with a common blood test used to check how well patients break down certain chemotherapy drugs (fluoropyrimidines). Researchers will measure DPD enzyme activity in about 742 people with breast or digestive cancer, kidney failu…