PROSTATE CARCINOMA

This trial tests a procedure called TULSA that uses MRI-guided ultrasound to heat and destroy prostate tumors without cutting into the body. It is for men aged 45-80 with low-to-intermediate grade prostate cancer that has not spread. The goal is to see if this approach can contro…

This study is for people with a type of advanced prostate cancer that has spread and stopped responding to standard treatments. It compares the usual fixed schedule of 6 doses of a radioactive drug (Lu-PSMA) given every 6 weeks to a flexible schedule that allows up to 12 doses wi…

This study looks at whether time-restricted eating (intermittent fasting) or GLP-1 medications (semaglutide, tirzepatide) can reduce heart risks in prostate cancer patients receiving hormone therapy. About 60 men will be randomly assigned to one of these approaches or a standard …

This study tests whether combining two drugs—pembrolizumab (an immunotherapy) and 177Lu-PSMA-617 (a targeted radiation therapy)—can slow the growth of advanced prostate cancer that has stopped responding to hormone treatments. About 48 men with metastatic castration-resistant pro…

This study is for men with high-risk prostate cancer that hasn't spread far. It tests whether adding the drug niraparib to standard hormone therapy after radiation can better control the cancer. About 200 participants will receive either hormone therapy alone or with niraparib. T…

This study is testing a new way to detect prostate cancer by looking at cells in urine using a special imaging method. Researchers will collect urine samples from 675 men, including those with and without prostate cancer, to see how accurate the test is. If successful, this could…

This study tests whether a special PET/CT scan using flotufolastat F 18 can accurately find prostate cancer that remains or returns after focal therapy. About 81 men who had focal therapy in the past 6-36 months will get the scan. If successful, this imaging method could offer a …

This study tests whether a special PET/CT scan using a radioactive tracer (flotufolastat F 18) can better guide prostate biopsies than standard MRI. About 30 men with suspicious MRI findings will get both types of scans before biopsy. The goal is to see if the new method finds mo…

This study tests whether an artificial intelligence (AI) system can analyze prostate MRI scans as accurately as a radiologist to detect prostate cancer. About 130 men who need a prostate biopsy will have their MRI read by both the AI and a radiologist. The goal is to see if the A…

This study tests a drug called fezolinetant to see if it can reduce hot flashes in men with prostate cancer who are on hormone therapy (ADT). About 60 men will take either the drug or a placebo daily for 4 weeks. Researchers will track hot flash frequency, severity, and any liver…

This study tests an internet-based program (iLIVE) that combines weight loss and resistance training to help men who have had prostate cancer and hormone therapy. The goal is to reduce obesity and frailty, which can improve quality of life and lower fall risk. About 250 participa…

This study tests whether giving cancer treatment at home is preferred over going to a clinic. It involves 27 adults with various cancers in the Florida Panhandle. The goal is to see if home care improves patient satisfaction and is safe.

This study tests if sucking on popsicles during chemotherapy can reduce taste changes in prostate cancer patients. Taste changes are a common side effect of taxane chemotherapy. The idea is that the cold from the popsicles narrows blood vessels in the mouth, which may limit how m…

This study tests a new proton therapy technique called 'Spot Delete' for men with low- to intermediate-risk prostate cancer. The goal is to reduce bowel and bladder side effects by preventing proton beams from stopping in sensitive areas. The study will enroll 500 participants an…

This study tests whether using bright white light therapy glasses can reduce fatigue and improve mood in men with advanced prostate cancer who are on hormone therapy. About 210 men will either start light therapy right away or wait a few months. The goal is to help patients feel …

This study tests whether using a computer program (RapidPlan) to plan radiation therapy for prostate cancer leads to fewer side effects than the current method where a human expert creates the plan. About 108 adults with prostate cancer will be randomly assigned to one of the two…

This study tests whether adding social support to group exercise helps older men (65+) with prostate cancer feel less lonely and improve their mental and physical health. 150 men will be assigned to one of three 6-month programs: socially-enhanced group exercise, standard group e…

This study tests whether light therapy and occupational therapy can help reduce cancer-related fatigue in people with bladder, kidney, or prostate cancer. About 224 participants who are on active treatment will be assigned to receive light therapy, occupational therapy, both, or …

This study explores whether specific breathing exercises can boost brain and mental health in people with multiple sclerosis or certain cancers, as well as their caregivers. Researchers will use brain scans to measure oxygen delivery and fluid flow in the brain. The goal is to un…

This study explores whether a virtual robot assistant can help Black men recently diagnosed with prostate cancer get the support and information they need. Researchers will work with patients and doctors to build and test the tool, focusing on how well it is accepted and used. Th…

This study is testing new blood tests that look for signs of many different cancers at the same time. The goal is to see if these tests can find cancer early, when treatment works best. About 24,000 adults aged 45 to 75 who do not have cancer will take part. They will be placed i…

This study at Mayo Clinic tests new AI image-processing methods (AIR Recon DL and Sonic DL) to see if they can improve MRI quality and shorten scan times for people being screened for prostate or endometrial issues. Sixty adults will receive standard and AI-enhanced scans, which …

This study sets up Community Living Labs at American Legion Posts to help Black men learn about prostate health and get screened. Community health workers will connect men to doctors and services. The goal is to see if this approach improves access to care and reduces prostate ca…

This study enrolls 300 men with advanced prostate cancer to donate blood, urine, tissue, and health information over time. The goal is to create a research resource that helps scientists better understand the disease and improve future treatments. No new drug or treatment is bein…

This study tests whether an online platform helps cancer patients track medication safety events and concerns while taking oral anticancer drugs at home. About 80 adults with lung, colorectal, breast, or prostate cancer will use the system to log symptoms and issues. Researchers …

This study aims to understand why African American men with prostate cancer often miss out on genetic testing and whether a community-based health coach can help. Researchers will provide culturally tailored education and track how many men choose to get tested. The goal is to le…

This early study tests a radioactive imaging agent called 99mTc-PSMA-I&S in 30 men with prostate cancer who are scheduled for lymph node removal surgery. The goal is to see how the agent spreads in the body and whether it can help surgeons detect cancer that has spread to lymph n…

This study looks for better ways to find aggressive prostate cancer early in people who have a genetic risk. Researchers will collect blood, urine, and tissue samples from 450 participants aged 40 and older with certain gene changes. The goal is to improve screening and treatment…