PROSTATE CARCINOMA

This early-stage study tests an experimental pill, ATV-1601, in people with advanced solid tumors (including certain breast, ovarian, and prostate cancers) that have a specific AKT1 gene mutation. The main goals are to check the drug's safety, find the best dose, and see how the …

This study compares two types of brachytherapy (radiation placed directly into the prostate) for men with localized prostate cancer. One type uses high-dose radiation given in a few minutes, while the other uses low-dose seeds that stay in place. The goal is to see which approach…

This study looks at whether the drug olaparib, taken after initial chemotherapy, can help control aggressive variant prostate cancer (AVPC) for longer. About 96 men will receive cabazitaxel, carboplatin, and prednisone first, then either olaparib or observation. The goal is to se…

This study looks at whether a concentrated form of green tea (green tea catechins) can stop or slow the growth of low-risk prostate cancer in men who are not receiving immediate treatment. About 360 men on active surveillance will take either the green tea extract or a placebo fo…

This study tests whether adding darolutamide to standard hormone therapy (ADT) after prostate removal surgery can delay or prevent cancer from spreading in men at highest risk. About 27 participants will receive either darolutamide or a placebo alongside ADT. The goal is to see i…

This study looks at whether a special whole-body MRI can accurately find cancer that has spread to the bones or lymph nodes in men with high-risk prostate cancer. About 98 participants will get this MRI along with standard bone and CT scans to compare results. The goal is to see …

This study tests whether a special ultrasound with tiny gas-filled bubbles can spot prostate cancer without a needle biopsy. Seventy men scheduled for prostate removal will receive an injection of these bubbles before imaging. If successful, this method could offer a faster, less…

This study tests whether a modified MRI scan (called Dixon sequencing) can produce clearer images of prostate cancer than the standard MRI. Researchers will compare the two methods in 65 men who have prostate cancer and are scheduled for prostate removal. The goal is to see if th…

This study was designed to test whether a special type of PET/MRI scan (using a radioactive tracer called 18F-DCFPyL) can better detect aggressive prostate cancer compared to standard MRI in men with elevated PSA levels. The trial was withdrawn before enrolling any participants, …

This study tests a new 3D MRI technique to see if it can find prostate cancer better than standard MRI, without needing a special coil inside the body. About 33 men with untreated, intermediate- or high-risk prostate cancer who plan to have surgery will take part. The goal is to …

This study tests whether a new device called OmnEcoil can safely and effectively combine two prostate cancer tests—MRI and biopsy—into a single session. Currently, these are done separately, which means extra visits and procedures. The trial involves 45 men aged 45 and older with…

This study explores whether a PET scan using a special tracer (68Ga-PSMA-11) can help guide prostate biopsies to find serious prostate cancer more accurately. It involves 30 men who had a previous biopsy that was negative or unclear. The goal is to improve detection and reduce bo…

This study looks at whether a special type of MRI, called multiparametric MRI, can more accurately determine the stage of prostate cancer in people recently diagnosed. The goal is to help doctors better identify aggressive cancers and plan the right surgery. About 850 participant…

This study looks at whether having an empty bladder before CT simulation for prostate cancer radiation therapy is better than a full bladder. The goal is to see if it reduces urinary symptoms and makes treatment easier for patients. About 168 men with prostate cancer will take pa…

This study tests whether a combination of a stimulant drug (methylphenidate) and exercise can better reduce cancer-related fatigue in prostate cancer patients than either alone. About 200 men with prostate cancer who are scheduled for radiation and hormone therapy will participat…

This study looks at whether a procedure called prostatic artery embolization (PAE) can safely reduce urinary symptoms in men with low-risk prostate cancer who are about to have radiation therapy. Seventeen participants will receive PAE before radiation and be followed for 12 week…

This study looks at how useful a web-based virtual genetics board is for doctors who treat or screen men for prostate cancer. The board helps providers discuss genetics cases, precision treatments, and screening recommendations. Researchers will interview and survey healthcare pr…

This research study aims to collect tissue, blood, and other samples from 2,400 people diagnosed with breast, colon, kidney, liver, multiple myeloma, or prostate cancer at a young age. The goal is to identify genetic changes that may explain why these cancers occur early in certa…

This study tests a web-based education tool called HOPE-Genomics that teaches cancer patients about their genetic test results. About 465 adults with lung, breast, colorectal, pancreatic, ovarian, or prostate cancer are taking part. The goal is to see if the tool helps patients r…

This study tests whether a new imaging system (RefleXion RMRS) can produce clear PET-CT scans of prostate cancer tumors, similar to standard scans. About 34 adults with prostate cancer will get both types of scans. If the new system works well, it may allow doctors to plan radiat…

This study looks at how hormone therapy (anti-androgen treatment) for prostate cancer may affect the heart. Researchers will use heart MRI scans before and after 4-7 months of treatment in 23 men. The goal is to understand changes in heart function, which could help doctors plan …

This study looks at whether a special PET scan using Posluma can help doctors better plan radiation therapy for prostate cancer. About 20 adults with prostate cancer will get an extra scan on the RefleXion X1 machine to compare with their standard scan. The goal is to improve how…

This study tests whether analyzing the genes in a patient's tumor can help doctors choose a more effective treatment. Over 6,400 adults with advanced or hard-to-treat cancers (solid tumors, lymphoma, or myeloma) had their tumors genetically screened. Those with specific genetic c…

This study looks at 28 men with intermediate to high-risk prostate cancer who are getting a precise type of radiation called stereotactic body radiotherapy. The goal is to see if early MRI scans can show whether the main tumor is responding to treatment, and if that matches chang…

This study follows 2,500 men who had surgery for prostate cancer at City of Hope, at least one year after their operation. Researchers collect data on quality of life, sexual health, and long-term complications to better understand survivors' health. The goal is to use this infor…

This study aims to understand how social factors—like where someone comes from—affect the way immigrant men from Sub-Saharan Africa and the Caribbean seek care and make decisions about prostate cancer. Researchers will interview 80 men to learn about their experiences and identif…

This study looks at inherited gene mutations (like BRCA1 and BRCA2) in men with prostate cancer. Researchers will test saliva samples and review health histories to understand how these mutations affect cancer risk and treatment. The goal is to improve screening and care for pati…

This study looked at whether regular screening tests for prostate, lung, colorectal, and ovarian cancers can help find cancer early and reduce the number of people who die from these cancers. Over 76,000 men and women took part, with some getting routine screening and others gett…

This study looks at tiny particles called extracellular vesicles that come from prostate cancer cells. Researchers want to see if levels of these particles in blood and urine change after surgery to remove the prostate. The goal is to learn if these particles can help doctors und…