Postoperative complications

This trial tests whether giving heated and humidified oxygen during recovery from general anesthesia can reduce the chance of early hypoxemia—a dangerous drop in blood oxygen levels—compared to standard room-temperature oxygen. About 2,000 adults undergoing surgery will be random…

This trial tests two strategies for managing blood pressure during off-pump coronary artery bypass grafting (a type of heart surgery done without a heart-lung machine). It asks whether keeping average blood pressure at 65 mm Hg or higher during surgery reduces the chance of major…

This trial compares two methods for closing the main artery in the leg after a TAVI procedure, which replaces a heart valve without open surgery. Half of the participants will have the artery closed with a single suture device, while the other half will receive a hybrid approach …

This trial tests whether closing the surgical wound immediately after cleaning it with a special high-pressure irrigation technique (HIEDI) is as good as or better than waiting a few days to close it. The study involves 200 people aged 12 and older who have open surgery for compl…

Researchers at University Hospital of Split are studying whether short-term changes in body-impedance readings after a standard intravenous fluid infusion can help predict complications after elective colon or rectal surgery. About 120 adults scheduled for these operations will r…

This study tests whether applying vancomycin powder directly into the surgical wound during shunt placement can prevent infections in children with hydrocephalus. About 164 children will be randomly assigned to receive either standard care or standard care plus the powder. The go…

This study tests whether using a high-flow nasal cannula (a device that delivers warm, moist oxygen at high speeds) for 24 hours after major abdominal surgery can prevent lung complications like pneumonia or collapsed lungs. Researchers will compare this to standard oxygen therap…

This study tests a surgical technique done at the same time as breast cancer lymph node removal to prevent arm lymphedema (chronic swelling). The procedure uses a small flap of tissue from the side of the chest to rebuild the armpit area and support fluid drainage. One hundred hi…

This trial compares two short-acting opioids, remifentanil and fentanyl, given during general anesthesia to see which better prevents emergence delirium, a state of confusion and agitation that affects up to 80% of children after surgery. Researchers will enroll 176 children aged…

This trial tests whether acupressure, a non-invasive therapy using finger pressure on specific body points, can help adults recovering from cardiac surgery. The goal is to see if it reduces postoperative pain and improves respiratory performance, potentially making breathing exer…

This study looks at whether removing the chest tube right after lung surgery (called a tubeless strategy) helps patients recover faster with less pain. About 300 adults having a specific type of lung surgery will be randomly assigned to one of three groups: standard chest tube, o…

This study tests whether ultrasound of the optic nerve sheath, a marker of brain pressure, can track brain swelling during ascending aortic surgery. Researchers will measure the optic nerve sheath diameter before, during, and after surgery in 134 adults undergoing this procedure.…

This study tests whether a non-invasive sensor placed on the back can detect early signs of kidney injury in adults undergoing off-pump coronary artery bypass surgery. Kidney injury is common after such surgery, but current detection relies on blood tests that rise days later. Th…

This study looks at whether nutritional risk and muscle thickness can help predict recovery in adults aged 65 and older after hip fracture surgery. Researchers will measure nutritional status using a standard score and check muscle thickness in the thigh with a quick, painless ul…

This study looks at whether the biological age of a person's blood vessels, measured before heart surgery, can help predict their risk of acute kidney injury afterward. Researchers will assess vascular aging using noninvasive tests and routine lab results in about 470 adults unde…

This study looks at how different types of bilateral breast reconstruction affect women's quality of life and satisfaction. Researchers will compare women who had preventive mastectomy (due to high risk) with those who had therapeutic mastectomy (due to cancer), and also consider…

This study observes 150 infants and toddlers having cleft lip or palate repair to understand how often breathing complications occur and what factors increase risk. Researchers will use standard airway scoring tools to see if they can predict problems like laryngospasm or low oxy…

This study will test whether using higher or standard pressure on a ventilator during surgery helps patients breathe better after waking up. About 360 adults having planned non-chest, non-heart surgery will be randomly assigned to one of two pressure levels. The main goal is to s…

This study looks at 1,000 adults who had planned heart bypass surgery. Researchers will review existing hospital records to see if changes in routine blood tests (like inflammation and kidney markers) in the first hours after surgery can identify patients at higher risk for compl…

This pilot study tests whether a virtual, home-based prehabilitation program is practical for adults awaiting major elective surgery. About 120 participants will be randomly assigned to either the program (exercise, nutrition, mindfulness, and protein supplements) or standard car…

This study looks at a new way to close the belly wall during large hernia surgery to prevent breathing problems right after the operation. Doctors will use standard breathing measurements during surgery to decide the best closure method. The study will include 50 adults who are a…

This study will create a tool to predict complications after major surgery in people aged 65 and older. Researchers will collect information on physical activity, nutrition, mood, and body composition from 520 participants before surgery. The goal is to help doctors better identi…

This study looks at whether a special hospital program for older adults (65+) who need surgery can improve their outcomes. Researchers will compare patients treated before and after the program started, tracking deaths and complications within 28 days. About 150 participants will…

This study looks at how low body temperature during lung cancer surgery (using a tiny camera) affects pain and complications after the operation. About 144 adults having this surgery will have their temperature tracked continuously. The goal is to understand if getting cold durin…

This study will look back at the records of 1,000 surgery patients who were admitted to the intensive care unit (ICU) in Villavicencio, Colombia, between 2022 and 2024. The goal is to understand what patient and surgery factors are linked to worse outcomes, such as death in the I…