POSTOPERATIVE ANALGESIA

This study tests a new medicine called HRS-2129 to see if it can better control pain after abdominal surgery. About 360 adults having abdominal surgery will receive either HRS-2129 or a standard painkiller. The main goal is to measure how much pain relief patients feel during the…

This study compares two pain medicines, oliceridine and sufentanil, given through a patient-controlled pump after brain surgery. The goal is to see if oliceridine causes less nausea, a common side effect of opioids. About 174 adults having surgery in the back of the skull will ta…

This study tests whether giving a combination of two drugs (lidocaine and dexmedetomidine) during laparoscopic weight-loss surgery can reduce pain, inflammation, and oxidative stress afterward. About 104 adults having bariatric surgery will be randomly assigned to receive the com…

This study compares two types of ultrasound-guided pain injections (TAP block and TFPB) in 36 children aged 6 months to 16 years who are having laparoscopic surgery. The goal is to see which injection provides better pain relief after surgery, how long the relief lasts, and wheth…

This study compares two ways to dilute the numbing drug bupivacaine for arm blocks: one with sugar water (D5W) and one with normal salt water. Researchers want to see if sugar water helps the block work faster or last longer. 90 adults having arm surgery will take part.

This study looks at whether a specific nerve block (erector spinae plane block) can reduce pain after laparoscopic abdominal surgery. Researchers will measure how long it takes for patients to need extra pain medicine and how much morphine they use. The study involves 50 adults u…

This study compares two types of nerve blocks—Erector Spinae Plane (ESP) and Lateral Transversus Abdominis Plane (TAP)—to see which provides better pain relief after open appendix removal. About 68 adults having open appendectomy will be randomly assigned to receive one of the bl…

This study compares two ways to manage pain after major abdominal cancer surgery: a nerve block (TAP block) versus an epidural. The goal is to see which method is safer and reduces the need for morphine. The study will enroll 50 adults undergoing surgeries like gastrectomy or col…

This study tests whether a long-acting numbing medicine (bupivacaine liposome) combined with standard numbing medicine can better control pain after lung surgery. About 496 adults having their first lung lobe removal will receive a nerve block before surgery. The goal is to see i…

This study compares two types of nerve blocks (PENG block and Deep Iliacus Plane Block) to see which provides better pain relief for people with hip fractures. The blocks are given before spinal anesthesia and after surgery. The goal is to reduce pain during positioning for the s…

This study compares two different doses of an intravenous painkiller (ketorolac) given after a planned C-section. 126 women will rate their pain on a 0-10 scale to see which dose provides better relief. The goal is to find the most effective dose to improve recovery and comfort a…

This study looks at whether a special ultrasound-guided nerve block (Quadro-Iliac Plane Block) can help control pain after lumbar spine surgery. About 60 adults having elective back surgery will be observed. The goal is to see if the block lowers pain scores and reduces the need …

This study compares two methods to reduce pain after laparoscopic hernia repair: injecting numbing medicine into the surgical area or using an ultrasound-guided nerve block (TAP block). Sixty adults having hernia surgery will be randomly assigned to one of the two groups. Researc…

This study tests whether a specific nerve block, given before surgery, can reduce pain and the need for strong painkillers after minimally invasive heart bypass surgery. Sixty adults will be randomly assigned to receive either the nerve block plus standard care or standard care a…

This study compares three standard pain relief methods used after open heart surgery: IV pain medicine, an epidural, and a nerve block. The goal is to see which method reduces the chance of long-term pain three months after surgery. Researchers will follow 90 adults and track the…