POST-TRAUMATIC STRESS DISORDER (PTSD)

This study tests a new stepped care program called PCT+2HOPE for women with opioid use disorder who have also experienced intimate partner violence and have PTSD symptoms. The program combines group therapy with optional individual sessions to address trauma and improve recovery.…

This study compares two treatments for veterans with PTSD who are at high risk for suicide. One combines Dialectical Behavior Therapy (DBT) with a PTSD-focused exposure therapy; the other is the current standard VA care. Researchers want to see which better reduces suicidal behav…

This study tests a new form of transcranial magnetic stimulation (TMS) for post-traumatic stress disorder (PTSD). Unlike standard TMS, which takes 6-7 weeks, this accelerated version delivers 10 sessions per day for 5 days. Researchers will enroll 40 adults with PTSD to see if ac…

This study tests whether giving oxytocin nasal spray before couples therapy can help veterans with PTSD feel better and improve their relationships. About 240 veterans and their partners will take part. Half get oxytocin, half get a placebo, and all receive eight sessions of brie…

This pilot study tests whether a therapy called EMDR can help reduce post-traumatic stress and psychological distress in people with advanced thyroid cancer. The study will enroll 25 participants who have cancer and PTSD. They will receive group and individual EMDR sessions, and …

This study tests a new way to deliver trauma-focused therapy to 40 teens aged 12-17 with PTSD. Half will use a secure mobile app alongside video and in-person sessions, while the other half receives standard therapy. The goal is to see if the blended approach is practical and hel…

This study tests a program called NurseNET, where nurses are trained to provide a short-term trauma therapy for PTSD. The goal is to make treatment easier to access for people who see their primary care nurse. Researchers will enroll 100 adults with PTSD symptoms and measure if s…

This study tests whether transcranial magnetic stimulation (TMS) can help teens aged 12-20 who still have PTSD symptoms after finishing trauma-focused therapy. About 20 participants will receive 10 TMS sessions over a month. The goal is to see if TMS is safe and acceptable, and t…

This study tests a handheld device called gammaCore that gently stimulates the vagus nerve through the skin on the neck. Researchers want to see if using it daily at home can safely reduce PTSD symptoms in adults. About 40 people with PTSD will use the device for 12 weeks while t…

This study tests whether short, educational videos sent by text message can help young people aged 15 to 25 manage symptoms of post-traumatic stress disorder (PTSD). Participants will either receive three videos per week for 10 weeks or wait to get them later. The goal is to see …

This study is testing a type of talk therapy for people who have both HIV and PTSD. The therapy helps people understand how trauma affects their emotions and relationships. The goal is to see if this therapy is helpful and acceptable for this group. About 20 adults with HIV and P…

This study tests whether 5 group sessions teaching mind-body skills can reduce PTSD symptoms and emotional problems in 120 adolescents aged 11-17 in Gaza who have experienced war-related trauma. Participants are randomly assigned to either the mind-body group or a control group, …

This study tests a new version of a therapy called RTM-C for children aged 6-14 with PTSD. The treatment uses child-friendly language, games, and animated tools to help kids safely replay difficult memories and reduce fear. About 40 children and their parents will take part in up…

This study tests whether a special computer-based brain training program can help adults with PTSD improve memory, attention, and daily functioning. Participants will be randomly assigned to either the brain training program or regular computer games, both with group discussions,…

This study tests a software program designed to reduce symptoms of post-traumatic stress disorder (PTSD). About 52 adults with PTSD will use the software or a placebo version. Researchers will measure changes in PTSD severity using a standard scale over the study period.

This small early study tests whether a gentle brain stimulation technique called temporal interference (TI) can safely reduce PTSD symptoms in 5 adults. Participants will receive TI stimulation and have their brain activity measured with MRI, MEG, and EEG. The goal is to see if s…

This study tests whether giving ketamine during surgery can reduce pain, lower the need for opioids, and improve depression and PTSD symptoms in adults with serious orthopedic injuries. About 90 participants will be randomly assigned to receive either ketamine or standard anesthe…

This early-phase study tests whether a sublingual form of dexmedetomidine (BXCL501) is safe and shows promise for treating alcohol use disorder in people who also have PTSD. Ten heavy drinkers with PTSD will take the drug and be monitored for changes in blood pressure, anxiety, a…

This study tests a prescription wrist device called NightWare in 125 veterans with PTSD who have frequent nightmares. The device is designed to improve sleep quality by interrupting nightmares. Researchers also want to see if better sleep leads to improved cardiovascular health. …

This study tests whether a 2-week, fully remote program combining mild brain stimulation (tDCS) with prolonged exposure therapy can reduce chronic pain and PTSD symptoms. About 146 adults with both conditions will receive either real or sham stimulation alongside therapy, all fro…

This study tests whether adding a digital mindfulness program to usual care helps adults aged 18-65 recover from emotional disorders like depression, anxiety, OCD, PTSD, and eating disorders. Participants attend online group sessions and use a WeChat mini-program for daily exerci…

This study tests a new therapy called the Reconsolidation of Traumatic Memories (RTM) Protocol for people with PTSD in Ukraine. The goal is to reduce distressing symptoms like flashbacks and anxiety without requiring patients to relive their trauma in detail. The study will invol…

This study uses a special PET scan tracer to measure a brain protein called PDE4B in people with PTSD or alcohol use disorder. Researchers want to see if levels of this protein differ from healthy individuals. The study involves 160 adults aged 18 to 70 and does not offer treatme…