PHARMACOKINETICS

This early-stage study tested a new drug called boserolimab (MK-5890), either alone or combined with the immunotherapy Keytruda, in 182 adults with advanced solid tumors, including lung and triple-negative breast cancers. The main goals were to check safety and how the drug moves…

This study tested a new sustained-release (slow-release) tablet of pyridostigmine, a drug used to treat myasthenia gravis, against the standard immediate-release tablet. Forty healthy Chinese volunteers took both versions in random order, separated by a washout period. Researcher…

This study tested whether giving the antibiotic cefoxitin using a target-controlled infusion pump works better than the standard method to prevent surgical site infections in patients having colon or rectal surgery. About 2,500 adults took part. The goal was to see if the new met…

This study tested whether giving the drug pasireotide with a reusable pen works as well as using a traditional syringe. Forty healthy adults received a single dose by both methods to compare how the drug enters the body and if it is safe. The goal is to find a more convenient way…

This completed Phase 4 trial studied how sugammadex, a drug that reverses muscle relaxants, works in 48 patients undergoing laparoscopic surgery. Researchers measured drug levels in the blood and how quickly patients recovered muscle function. The study focused on patients with a…

This study tested whether a new rapid-acting insulin (called I004) works the same as the approved insulin NovoLog. Sixty-nine healthy volunteers each received a single dose of both insulins at different times, and researchers measured how quickly the insulin entered the blood and…

This study tested whether taking a new antibiotic (ceftibuten/VNRX-7145) with food changes how the body absorbs it. Twenty-four healthy adults took the drug once while fasting and once after a meal. Researchers measured drug levels in the blood to see if food affects safety or ef…

This study looked at how the sedative drug ciprofol is processed in the body of people with moderate to severe low blood protein (hypoproteinemia). Researchers measured drug levels in the blood after a single injection in 36 patients. The goal was to understand dosing and timing,…

This early-phase trial tested the safety of a new drug called BB-025, designed to reverse the effects of another experimental drug, BB-031. 72 healthy volunteers received either BB-025 or a placebo, alone or after BB-031, and were monitored for 28 days. The main goal was to check…

This early-stage trial tested the safety and drug levels of noribogaine in 55 healthy adults aged 18 to 45. Participants received either the drug or a placebo, and researchers measured how the drug was processed by the body. The goal was to gather safety information, not to treat…

This study tested a vaginal ring that slowly releases two medicines: dapivirine (to prevent HIV) and levonorgestrel (a contraceptive). Forty healthy women without HIV used the ring for 90 days. Researchers measured drug levels in blood and vaginal fluid and checked for side effec…

This study looked at how moderate liver problems affect the way the body handles a new experimental cancer medicine called sevabertinib. About 20 people—half with liver impairment and half healthy—took a single dose and had their blood levels measured over 5 days. The goal is to …

This study tested whether a computer model can help doctors give the right dose of anti-rejection drugs to children after a kidney transplant. The model used drug levels from blood samples to predict future exposure and guide dosing. 29 children participated, and the goal was to …

This study looked at how the investigational drug MRX1 is processed by the body, its safety, and whether food changes its absorption. Twenty healthy adults took multiple doses of MRX1. The goal was to gather basic information, not to treat any disease.

This study looked at how safe kratom is and how the body processes it in healthy adults who have used opioids recreationally. 40 participants received single rising doses of kratom to monitor side effects and drug levels. The goal was to gather basic safety information, not to tr…

This study looked at how two antibiotics, ceftibuten and ledaborbactam, move through the blood and lungs of 34 healthy adults aged 18 to 55. Participants took the drugs for several days and then had a bronchoscopy to collect lung fluid samples. The goal was to measure drug levels…

This study looked at how a single dose of the antibiotic combination ceftibuten/VNRX-7145 moves through the bodies of 32 adults with normal kidney function, mild to severe kidney problems, or end-stage kidney disease on dialysis. Researchers measured drug levels in the blood and …