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New vaginal ring aims to prevent HIV and pregnancy in one device

NCT ID NCT05041699

First seen Apr 06, 2026 · Last updated Jun 17, 2026 · Updated 10 times

Summary

This study tested a vaginal ring that slowly releases two medicines: dapivirine (to prevent HIV) and levonorgestrel (a contraceptive). Forty healthy women without HIV used the ring for 90 days. Researchers measured drug levels in blood and vaginal fluid and checked for side effects and bleeding changes. The goal was to see if the ring is safe and how the drugs are absorbed.

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Contacts and locations

Locations

  • Oregon Health & Science University

    Portland, Oregon, 97239, United States

  • UPMC Magee-Womens Hospital, Center for Family Planning Research

    Pittsburgh, Pennsylvania, 15213-3180, United States

Conditions

The condition(s) this trial relates to.

Hemorrhage hemorrhagic disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.