PHARMACOKINETICS

This study compares a new rapid-acting insulin called I004 to the approved insulin NovoLog in 60 healthy adults. Researchers want to see if the two insulins are similar in how they work in the body. If they are, I004 could become a more affordable option for managing diabetes.

This study tests an experimental pill called IPG7236 in people with advanced solid tumors that have spread or cannot be removed. The main goals are to check the drug's safety, find the best dose, and see if it can shrink tumors. About 196 adults will take the pill twice daily in …

This study tests a long-acting painkiller (liposomal bupivacaine) against a standard one (plain bupivacaine) for pain after chest surgery. About 40 adults having minimally invasive chest surgery will receive one of the two drugs injected between the ribs. Researchers will measure…

This Phase 1 trial is testing a new drug called linaprazan glurate in 121 healthy adults to see how the body absorbs and processes it, and whether it affects heart rhythm. The study is double-blind and placebo-controlled, meaning some participants get a dummy pill. It is an early…

This study looks at how smoking high-potency cannabis affects pain relief, feelings of being high, and drug levels in the blood. Researchers will test 30 near-daily cannabis users who are not seeking treatment. Participants will smoke either placebo, low-dose, or high-dose THC ca…

This early-stage study compares two forms of the cholesterol-lowering drug evolocumab in 400 healthy adults aged 18 to 60. Participants receive a single injection of one version, and researchers measure how much drug gets into the blood and how long it stays. The goal is to see i…

This study tests how a new painkiller called PF614, given alone or with another drug (nafamostat), moves through the body. It involves 54 healthy adults aged 18 to 55. The goal is to measure drug levels and safety, not to treat any disease.

This early-stage study tests a new antibiotic combination (ceftibuten-ledaborbactam) in 46 healthy adults aged 18-55. The goal is to check safety and how the drug moves through the body, not to treat any disease. Participants will stay at a clinic for several days and have follow…

This study looks at how antibiotics behave in the bodies of critically ill newborns, infants, and children who are on a heart-lung machine called ECMO. Researchers want to find out if current doses are high enough to fight infections without causing harm. The goal is to improve d…

This study looks at how the antifungal medicine caspofungin behaves in children with severe infections, especially those with liver problems or on life support like ECMO. Researchers will measure drug levels in the blood to understand dosing needs. About 60 children in intensive …

This study looks at whether standard antibiotic doses are effective for children in the pediatric intensive care unit. Researchers will measure drug levels in the blood of 640 children to see if they reach the right targets to fight infections. The goal is to improve dosing guide…

This early-stage study tests whether a single inhaled dose of RCS-21 is safe and tolerable in 24 healthy volunteers aged 18 to 64. Participants receive either the drug or a placebo and are closely monitored for side effects and how the drug moves through the body. The study does …

This study looks at how the body processes kava and kratom when taken together compared to taking each one alone. It involves 18 healthy adults who will try all three options in a random order. The goal is to understand any interactions, not to treat any disease.

This study looks at how antibiotics like amoxicillin and metronidazole work in the body when used with deep cleaning for severe gum disease. Researchers want to find the best dose and treatment length (3 vs 7 days) to kill harmful bacteria without overusing antibiotics. About 45 …