Osteoarthritis (OA) of the knee

This study looks at whether adding a bone marrow injection to standard knee surgery can improve pain and function for people with cartilage or meniscus injuries. Fifty adults aged 18 to 64 will be randomly assigned to get either the bone marrow injection or a placebo saltwater in…

This trial tests whether adding platelet-rich plasma (PRP) made from a person's own blood to a standard hyaluronic acid injection provides better knee pain relief than hyaluronic acid alone. About 100 adults with moderate knee osteoarthritis will receive one injection of either t…

This trial tests whether adding platelet-rich plasma (PRP) — made from a person's own blood — to a standard hyaluronic acid injection improves knee pain and function in people with knee osteoarthritis. Half of the 50 participants receive the combined injection, while the other ha…

This study tests a 3-month virtual program called Choose to Move Replacement Ready for people on waitlists for hip or knee replacement due to osteoarthritis. The program offers choice-based physical activity and group support to help participants stay active, reduce pain, and imp…

This trial tests whether adding metformin, a common diabetes medication, to a program of diet and exercise can reduce knee pain and improve function in overweight or obese adults with knee osteoarthritis. Participants will receive either metformin or a placebo for six months, alo…

This study tests whether Mobithron Advance, a daily oral supplement made from undenatured type II collagen, can slow or reverse cartilage loss in people with knee osteoarthritis. Over 12 months, 84 participants will take either the supplement or a placebo. Researchers will use MR…

This study tests a 12-week digital exercise program for people who had ACL knee surgery. The program uses sensors to help correct how the knee moves during walking, with the goal of reducing joint inflammation and preventing osteoarthritis. Researchers will enroll 60 adults aged …

This study compares two types of robotic-arm assisted knee replacement surgery in 120 people with knee osteoarthritis. One group gets cementless implants, the other gets cemented implants. The main goal is to see which approach helps patients 'forget' they have an artificial knee…

Researchers compare two platelet-based injections, platelet lysate and platelet-rich plasma, against a saline placebo in adults aged 50 to 80 with mild to moderate knee osteoarthritis. Participants receive one injection into the knee and researchers track pain, joint function, X-…

This study tests a device that uses focused sound waves to block pain signals in the knee, offering a needle-free option for people with chronic osteoarthritis pain. Ten adults with moderate to severe knee pain will receive a one-hour treatment and be followed for six months. The…

This trial compares two injection sites for steroid shots in people with moderate-to-severe knee osteoarthritis. Participants get the injection on either the inside or outside of the knee, then report pain and function over 12 weeks. The goal is to see if one spot provides better…

This Phase 2 trial tests a single injection of a gene therapy called PCRX-201 in 135 adults aged 45–80 with painful knee osteoarthritis. Participants receive one of two doses or a placebo, then are monitored for safety and pain relief over 5 years. The goal is to see if the injec…

This trial tests whether a genicular nerve block given before knee replacement surgery can reduce pain and the need for opioids. About 70 adults with knee osteoarthritis will receive either the nerve block or a placebo injection. Researchers will track pain levels, opioid use, an…

This study compares three pain control methods for total knee replacement: a standard injection of pain medicine into the knee during surgery, a new long-acting medication called Zynrelef, and a nerve block given before surgery. The goal is to see if Zynrelef can control pain as …

This trial tests whether adding a short course of oral steroids (prednisone or dexamethasone) to standard pain medication (ibuprofen) better relieves acute osteoarthritis pain in the knee, hip, or shoulder for adults visiting the emergency department. Participants are randomly as…

This study compares two robot-assisted knee replacement methods for people with severe knee arthritis. One method uses a CT scan to plan the surgery (image-based), while the other uses a simpler approach without a scan (imageless). The goal is to see if the imageless method works…

This study is testing whether giving a steroid injection to the knee that is not being operated on can help reduce pain and improve function for people undergoing total knee replacement. The study will involve 60 adults with knee osteoarthritis who are scheduled for a single knee…

This study tests a modular, powered leg brace (exoskeleton) designed to assist knee movement and reduce pain in people with knee osteoarthritis. The brace provides a small amount of torque to help the joint, potentially lowering muscle effort and painful loads on the knee. Resear…

This study tests whether a team of pharmacists and physiotherapists can help people with early knee osteoarthritis manage their condition. Participants will get one-on-one pharmacist care, including medication review and education, plus individual or group physiotherapy sessions.…

This trial tests whether a short, temporary nerve stimulation can reduce pain in people with moderate to severe knee osteoarthritis. About 100 adults aged 30 to 70 who have not found relief from oral pain medications or physical therapy will receive a brief electrical pulse to sp…

This study will follow 10,000 adults with common joint or tendon problems—like knee arthritis, tennis elbow, or plantar fasciitis—who choose to receive a platelet-rich plasma (PRP) injection. PRP is made from a patient's own blood, spun to concentrate healing factors. Participant…

This study tests whether a painless, needle-free treatment called transcutaneous pulsed radiofrequency acupuncture can reduce pain and stiffness in people with knee osteoarthritis. About 90 adults aged 45 to 85 with long-term knee pain will receive the treatment along with standa…

This study tests whether a supplement made from boswellia, turmeric, and grape extracts can reduce pain and stiffness in people with knee or hip osteoarthritis. Thirty adults will take the supplement or a placebo for four weeks each, then switch. Researchers will measure changes …

This study tests whether using virtual reality for relaxation exercises can reduce pain and improve sleep better than traditional relaxation methods in people recovering from hip or knee replacement surgery. About 82 adults who speak Turkish and have no mental or sleep disorders …

This study tests whether combining functional electrical stimulation (FES) with exercise can improve quadriceps muscle strength and reduce pain in people with knee osteoarthritis. Researchers will measure muscle strength, pain levels, and quality of life in 52 participants aged 5…

This study will follow 500 people with knee injuries or knee osteoarthritis who receive standard care at a hospital in China. Researchers will collect medical history, imaging, and function tests at the start and then again at 6, 12, and 24 months. The goal is to better understan…

This study looks at whether a 3-month virtual program called Choose to Move Replacement Ready is feasible for people waiting for hip or knee replacement surgery due to osteoarthritis. About 60 participants will answer surveys and some will be interviewed. The goal is to see if th…