OSTEOARTHRITIS (OA) OF THE KNEE
Clinical trials for OSTEOARTHRITIS (OA) OF THE KNEE explained in plain language.
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New knee injection aims to ease arthritis pain in 53-Week trial
Disease control OngoingThis study tests whether TPX-100 injections into the knee can safely reduce pain and improve function in people with mild to severe knee osteoarthritis. About 270 adults aged 50 to 80 will receive either the study drug or a placebo over 53 weeks. The main goal is to check for sid…
Matched conditions: OSTEOARTHRITIS (OA) OF THE KNEE
Phase: PHASE2 • Sponsor: OrthoTrophix, Inc • Aim: Disease control
Last updated May 26, 2026 05:22 UTC
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Cold injection could ease knee pain without surgery
Symptom relief OngoingThis study tests a new treatment called Neural Ice, which uses cold energy injected into the knee to relieve chronic pain from osteoarthritis. About 263 adults aged 22 to 80 with moderate to severe knee pain are taking part. The goal is to see if this therapy reduces pain during …
Matched conditions: OSTEOARTHRITIS (OA) OF THE KNEE
Phase: NA • Sponsor: Brixton Biosciences, Inc. • Aim: Symptom relief
Last updated May 26, 2026 05:31 UTC
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New knee brace and simple exercise combo could ease arthritis pain
Symptom relief ENROLLING_BY_INVITATIONThis study tests a new knee brace designed to correct alignment and reduce joint pressure, along with a special low-intensity exercise method called blood flow restriction (BFR) training. Researchers will compare the new brace to a traditional one in 40 volunteers over age 50 wit…
Matched conditions: OSTEOARTHRITIS (OA) OF THE KNEE
Phase: NA • Sponsor: China Medical University Hospital • Aim: Symptom relief
Last updated May 22, 2026 13:54 UTC
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New knee shot aims to ease arthritis pain for years
Symptom relief OngoingThis study tests a single knee injection of an experimental drug called PCRX-201 in 135 adults aged 45–80 with painful knee osteoarthritis. The goal is to see if it is safe and tolerable, and to explore how well it reduces knee pain and improves joint function over up to 5 years.…
Matched conditions: OSTEOARTHRITIS (OA) OF THE KNEE
Phase: PHASE2 • Sponsor: Pacira Pharmaceuticals, Inc • Aim: Symptom relief
Last updated May 22, 2026 13:53 UTC
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New painkiller aims to replace opioids after knee surgery
Symptom relief ENROLLING_BY_INVITATIONThis study compares a new pain medicine called suzetrigine to the standard opioid oxycodone for pain after total knee replacement. About 140 adults with knee osteoarthritis will take either suzetrigine or oxycodone for two weeks after surgery. Researchers will measure pain levels…
Matched conditions: OSTEOARTHRITIS (OA) OF THE KNEE
Phase: PHASE4 • Sponsor: University of Louisville • Aim: Symptom relief
Last updated May 18, 2026 11:58 UTC
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Does an extra knee surgery during ACL repair raise arthritis risk? 10-year study aims to find out.
Knowledge-focused ENROLLING_BY_INVITATIONThis study follows 510 people who had ACL knee surgery 10 years ago to see if adding an extra procedure (called LET) increases the risk of developing knee arthritis. Participants had ACL reconstruction with or without LET between 2014-2017. Researchers will use X-rays and questio…
Matched conditions: OSTEOARTHRITIS (OA) OF THE KNEE
Phase: NA • Sponsor: Western University, Canada • Aim: Knowledge-focused
Last updated May 26, 2026 04:37 UTC