Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

Ear cartilage to the rescue? a tiny biopsy could rebuild knees

NCT ID NCT07755579

Disease control Sponsor: Regenera Activa Worldwide S.L. Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 10, 2026 · Last updated Aug 11, 2026 · Updated 1 time

Summary

This trial is testing whether a single injection of micrografts made from a patient's own ear cartilage can improve symptoms and knee function in adults with moderate knee osteoarthritis. The micrografts are prepared from a small ear cartilage sample using a special device, without lab culture. Researchers will track changes in knee pain, stiffness, and function over 12 months, and use MRI scans to see if cartilage thickness improves.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Autologous ear cartilage micrografting (Mytocel MSK) using Rigenera Technology
What this could lead to
If successful, this could offer a minimally invasive, one-time injection to ease knee osteoarthritis pain and potentially improve cartilage condition, delaying or avoiding more invasive surgery.
What could go wrong
This is a small, early-stage trial, so results may not be conclusive or generalizable. The procedure involves a biopsy and injection, which carry risks like infection or pain, and the micrografts may not effectively regenerate cartilage.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

33 people

The number who actually took part.

Started

May 2023

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diagnosed knee OA L-K grade II-III * Symptomatic knee OA (with pain) * Reduced mobility Exclusion Criteria: * Knee OA L-K grade IV * Systemic Joint Disease (e.g. rheumatoid arthritis) * Active autoimmune disease * Active Oncologic process * If other orthobiologic treatments administered in the last 3 months

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Moderate osteoarthritis are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

osteoarthritis osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Moderate osteoarthritis Osteoarthritis Osteoarthritis (OA) of the knee

Contacts and locations

Locations

  • Semmelweis University

    Budapest, 1085, Hungary

More trials for these conditions

Other studies related to the condition(s) this trial covers.