OSTEOARTHRITIS (OA) OF THE KNEE
Clinical trials for OSTEOARTHRITIS (OA) OF THE KNEE explained in plain language.
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Could this daily pill rebuild knee cartilage?
Disease control Not yet recruitingThis study tests a drug called Mobithron Advance in 84 adults aged 50 and older with mild to moderate knee osteoarthritis. Participants take the drug or a placebo daily for one year to see if it can slow cartilage loss and reduce pain. The goal is to find a safe treatment that he…
Matched conditions: OSTEOARTHRITIS (OA) OF THE KNEE
Phase: EARLY_PHASE1 • Sponsor: Universiti Sains Malaysia • Aim: Disease control
Last updated May 26, 2026 05:25 UTC
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Knee replacement pain relief: simple injection before surgery may cut opioid use
Symptom relief Not yet recruitingThis study tests whether a numbing injection (genicular nerve block) given before knee replacement surgery can lower pain and the need for strong painkillers afterward. About 70 adults with knee osteoarthritis will be randomly assigned to get either the nerve block or a placebo i…
Matched conditions: OSTEOARTHRITIS (OA) OF THE KNEE
Phase: NA • Sponsor: Helse Møre og Romsdal HF • Aim: Symptom relief
Last updated May 26, 2026 05:37 UTC
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Knee injection pain relief: study tests smaller needles and cooling spray
Symptom relief Not yet recruitingThis study looks at ways to make steroid injections into the knee less painful for people with osteoarthritis. Researchers will test if using a smaller needle or a cooling spray (ethyl chloride) reduces pain during the injection. About 88 adults with knee osteoarthritis will take…
Matched conditions: OSTEOARTHRITIS (OA) OF THE KNEE
Phase: PHASE4 • Sponsor: University of California, Davis • Aim: Symptom relief
Last updated May 26, 2026 05:37 UTC
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Diet study aims to ease arthritis pain and boost brain health
Symptom relief Not yet recruitingThis study looks at whether a carefully planned ketogenic diet can help people who have both osteoarthritis (joint pain) and mild cognitive impairment (memory issues). Ten adults will follow the diet under supervision for a period, and researchers will measure changes in pain, ph…
Matched conditions: OSTEOARTHRITIS (OA) OF THE KNEE
Phase: NA • Sponsor: University of Kansas Medical Center • Aim: Symptom relief
Last updated May 26, 2026 04:37 UTC
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Laser treatment shows promise for knee arthritis pain relief
Symptom relief Not yet recruitingThis study looks at whether high-intensity laser therapy, added to standard physiotherapy, can improve knee cartilage thickness and reduce pain in people with knee osteoarthritis. About 58 adults aged 40 to 60 with moderate knee arthritis will receive either laser plus physiother…
Matched conditions: OSTEOARTHRITIS (OA) OF THE KNEE
Phase: NA • Sponsor: University of Lahore • Aim: Symptom relief
Last updated May 22, 2026 14:05 UTC
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New painkiller aims to cut opioid use after knee replacement
Symptom relief Not yet recruitingThis study looks at whether a long-acting painkiller (bupivacaine-meloxicam) can reduce pain and the need for opioid painkillers after robot-assisted total knee replacement. About 150 adults aged 18 to 89 with knee osteoarthritis will take part. Researchers will measure pain leve…
Matched conditions: OSTEOARTHRITIS (OA) OF THE KNEE
Phase: PHASE4 • Sponsor: Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) • Aim: Symptom relief
Last updated May 22, 2026 13:51 UTC
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Weight-Loss drug before knee surgery may ease pain and speed recovery
Symptom relief Not yet recruitingThis early-phase study tests whether a GLP-1 weight-loss drug (semaglutide) taken before total knee replacement can reduce pain and improve recovery in obese adults with knee osteoarthritis. About 54 participants aged 40-80 with a BMI of 27 or higher will receive the drug or stan…
Matched conditions: OSTEOARTHRITIS (OA) OF THE KNEE
Phase: EARLY_PHASE1 • Sponsor: The University of Hong Kong • Aim: Symptom relief
Last updated May 19, 2026 11:46 UTC
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Robotic knee surgery showdown: can skipping the scan still deliver?
Symptom relief Not yet recruitingThis study compares two types of robotic-assisted knee replacement surgery for people with severe knee arthritis. One method uses a CT scan to plan the surgery, while the other does not. The goal is to see if the no-scan method works just as well for improving knee pain and funct…
Matched conditions: OSTEOARTHRITIS (OA) OF THE KNEE
Phase: NA • Sponsor: Medical University of Warsaw • Aim: Symptom relief
Last updated Apr 30, 2026 15:51 UTC
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New study to test if running helps or hurts arthritic knees in beginners
Knowledge-focused Not yet recruitingThis study looks at how starting a running program affects the knees of people with osteoarthritis. Researchers will use MRI scans to check knee cartilage health in 80 new runners, some with knee arthritis and some without. The goal is to learn whether recreational running is saf…
Matched conditions: OSTEOARTHRITIS (OA) OF THE KNEE
Phase: NA • Sponsor: University of British Columbia • Aim: Knowledge-focused
Last updated May 26, 2026 05:38 UTC
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500 knee patients to be tracked for injury and arthritis clues
Knowledge-focused Not yet recruitingThis study will follow about 500 people with knee injuries or knee arthritis to see how their knees heal and change over time. Participants get their usual care and are checked at 6, 12, and 24 months with scans and surveys. No new treatments or medicines are tested—the goal is s…
Matched conditions: OSTEOARTHRITIS (OA) OF THE KNEE
Sponsor: Ningbo No.2 Hospital • Aim: Knowledge-focused
Last updated May 26, 2026 04:37 UTC