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Does an extra knee ligament procedure lead to arthritis later?

NCT ID NCT06885372

Knowledge-focused Sponsor: Western University, Canada Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study follows 510 people who had ACL knee reconstruction surgery, with or without an extra procedure called LET, about 10 years ago. Researchers want to see if adding LET increases the chance of developing knee osteoarthritis. Participants will get X-rays and answer questions about knee pain and function. The goal is to help doctors and patients weigh long-term risks when choosing treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Lateral Extra-Articular Tenodesis (LET) procedure
What this could lead to
If successful, this study will clarify whether adding LET to ACL reconstruction raises the risk of knee osteoarthritis, helping surgeons and patients make better-informed decisions.
What could go wrong
This is an observational follow-up, not a new treatment test. Results may show no clear link or may not apply to all patients. The study relies on imaging and patient reports, which can vary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 510 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2024

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

14 to 25 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria: * ACL deficient knee * skeletally mature to 25 years of age * 2 or more of: * competitive pivoting sport * grade 2 pivot shift or greater * generalized ligament laxity - Beighton score of 4 or greater Exclusion criteria: * previous ACL reconstruction on either knee * multi-ligament injury (two or more ligaments requiring surgical attention) * symptomatic articular cartilage defect requiring treatment other than debridement * greater than 3 degrees of asymmetric varus * unable to complete outcome questionnaires

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Conditions

The condition(s) this trial relates to.

Anterior Cruciate Ligament Injuries lupus erythematosus tumidus osteoarthritis osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acl reconstruction LET Osteoarthritis (OA) of the knee

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    8 sites in 2 countries. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Banff Sport Medicine Clinic

    Banff, Alberta, T1L 1B3, Canada

  • Fowler Kennedy Sport Medicine Clinic

    London, Ontario, N6A 3K7, Canada

  • Fraser Health Authority

    New Westminster, British Columbia, V3L 5P5, Canada

  • McMaster University

    Hamilton, Ontario, L8N 3Z5, Canada

  • Pan Am Clinic

    Winnipeg, Manitoba, R3M 3E4, Canada

  • Queens University

    Kingston, Ontario, K7L 2V7, Canada

  • University Hospitals Coventry and Warwickshire NHS Trust

    Coventry, CV2 2DX, United Kingdom

  • University of Calgary

    Calgary, Alberta, T2N 1N4, Canada

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