OROPHARYNGEAL CANCER

This study tests a personalized approach to treating p16-positive oropharyngeal cancer (a type of throat cancer linked to HPV). The goal is to use less intense treatment—either surgery with tailored follow-up or customized chemoradiation—to maintain high cure rates while reducing…

This study tests giving chemotherapy and immunotherapy before standard surgery for head and neck cancer. The goal is to shrink tumors enough so that surgeons can do a less extensive operation, preserving speech, swallowing, and vision. About 75 adults with newly diagnosed, advanc…

This early-phase study tests whether injecting the numbing drug lidocaine directly into HPV-related throat tumors before robotic surgery is safe and can help kill more cancer cells. About 30 adults with oropharyngeal cancer will receive either lidocaine or no injection before the…

This study tests whether a special imaging scan (SPECT-CT) can help doctors decide to give radiation to only one side of the neck instead of both in people with oropharyngeal cancer. The goal is to see if this approach keeps the cancer from coming back while reducing side effects…

This study tests whether a blood test that detects HPV DNA can help doctors tailor the intensity of chemotherapy and radiation after surgery for HPV-positive throat cancer. About 50 participants will receive treatment based on their blood test results and standard risk factors. T…

This study tests whether giving the drug toripalimab with chemotherapy before surgery or a lower dose of radiation can shrink HPV16-positive throat cancer tumors. About 30 adults with advanced but not spread throat cancer will take part. The goal is to see if this approach improv…

This study is for people with HPV-positive throat cancer. It tests whether a much lower dose of radiation (30 Gy) combined with standard chemotherapy works as well as the usual high dose (70 Gy) to control the cancer, while causing fewer side effects. About 121 participants will …

This study is testing a new mouth swab test that looks for HPV DNA and certain gene changes to find throat cancer early. Researchers will compare results from 200 people with throat cancer and 200 healthy volunteers matched by age, sex, and background. If the test works well, it …

This study tests whether injecting a long-acting anesthetic called EXPAREL into the surgical wound can reduce pain and improve swallowing after robotic surgery for throat cancer. About 80 adults having this surgery will be split into two groups: one gets EXPAREL plus standard pai…

This study is testing whether a liquid biopsy (a blood or fluid test) can effectively monitor HPV-related cancers like cervical and throat cancer. Researchers will follow 480 patients for 4 years, collecting samples before, during, and after treatment to see if the test can detec…

This study is creating a huge collection of medical information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. The goal is to help researchers better understand cancer causes, improve early detection, and develop person…