OROPHARYNGEAL CANCER

This study is testing whether a much lower dose of radiation, combined with standard chemotherapy, can effectively control HPV-positive throat cancer while causing fewer side effects. It will compare a new, lower radiation dose (30Gy) against the current high standard dose (70Gy)…

This study is testing a new approach for people with advanced head and neck cancer. The goal is to see if giving a combination of chemotherapy and immunotherapy before surgery can shrink tumors enough to allow surgeons to perform less extensive operations. This could help patient…

This study is testing whether using special imaging to guide radiation treatment to only the affected side of the neck works as well as treating both sides for patients with throat cancer that hasn't spread across the midline. Researchers want to see if this more targeted approac…

This study is testing a personalized approach to treatment for people with HPV-linked throat cancer who have had surgery. The goal is to see if a simple blood test can help doctors decide who needs less intense follow-up therapy, aiming to control the cancer while reducing side e…

This study is testing two personalized approaches to treat early-stage throat cancer caused by HPV. The goal is to control the cancer effectively while using less intense treatments to reduce side effects. One approach starts with surgery, and the other uses tailored radiation an…

This study is testing a new treatment approach for HPV16-positive throat cancer that has not been treated before. Patients first receive an immunotherapy drug (toripalimab) combined with chemotherapy to shrink the tumor. Based on how well the tumor responds, patients then undergo…

This study is testing if an immunotherapy drug called balstilimab can clear the HPV virus from the blood of throat cancer patients who have finished their main treatment but still show signs of the virus. The goal is to see if clearing this leftover virus can help prevent the can…

This study is testing a new oral swab that looks for specific markers linked to HPV-related throat cancer. The goal is to see if this simple test can accurately find cancer early, when treatment is often more successful. Researchers will compare results from 200 people with throa…

This study is testing whether a long-acting numbing medicine, injected directly into the surgical area, can better control pain and help swallowing function after robotic surgery for throat cancer. Researchers will compare patients who receive this injection to those who do not, …

This study aims to see if simple 'liquid biopsies'—like blood tests, mouth rinses, and swabs—can help doctors monitor treatment and catch the early return of cancers caused by HPV (human papillomavirus). It will enroll 480 people with cervical or throat cancer or pre-cancer. Rese…

This study is building a large, long-term database of health information and biological samples from people with cancer, people at risk for cancer, and healthy volunteers. The goal is to collect this data to help researchers better understand what causes cancer and how to prevent…