OROPHARYNGEAL CANCER

This study was designed for people with HPV-positive oropharyngeal cancer who still have signs of the virus in their blood after finishing standard treatment. The goal was to see if an immunotherapy drug called BALSTILIMAB could clear the virus and improve long-term survival. How…

This study compares two treatments for advanced head and neck cancer: the immunotherapy drug pembrolizumab (Keytruda) plus radiation versus standard chemotherapy (cisplatin) plus radiation. About 126 participants with p16-positive cancer will be enrolled. The goal is to see if th…

This study tests whether a mix of three immunotherapy drugs can shrink tumors in people with advanced HPV-related cancers that have spread. About 51 adults with cancers like cervical, anal, or throat cancer will receive the drugs for up to a year. The goal is to control the disea…

This phase 3 trial compares different treatment combinations for people with intermediate or high-risk oropharyngeal cancer (a type of throat cancer). The goal is to find which approach works best to improve survival and reduce severe side effects. About 785 participants are bein…

This study tests an HPV vaccine (PRGN-2009) alone or with a drug called M7824 in adults with HPV-positive cancers like cervical, anal, and throat cancers. The goal is to find a safe dose and see if the combination boosts the immune system to fight the cancer better. Participants …

This study looks at whether giving lower doses of radiation to a smaller area after robotic surgery can still keep HPV-positive throat cancer from coming back. About 150 adults with early-stage cancer will receive this gentler treatment. The goal is to see if two years later the …

This study compares two standard treatments for HPV-related throat cancer: radiation therapy or surgery to remove the tumor. The goal is to see which approach leads to better survival and quality of life, especially swallowing function. The study involves 61 adults with early-sta…

This study tests a combination of three drugs (entinostat, PDS01ADC, and bintrafusp alfa) in adults with advanced cancers linked to HPV or certain colon cancers that haven't responded to standard treatments. The goal is to find a safe dose and see if the treatment can shrink tumo…

This study is testing whether a blood test (NavDx®) can find early signs of HPV-related oropharyngeal cancer by looking for tiny bits of HPV DNA in the bloodstream. Researchers are enrolling 9 people aged 45 and older with multiple sexual partners to see how many cases the test c…

This study tests whether an online tool called Empowered Survivor helps people who have had oral or throat cancer feel more confident managing their health. About 643 cancer survivors will use either the new tool or a standard online program. The goal is to see if the tool improv…

This study looks at whether skipping radiation to some lymph node areas can lower side effects without increasing the chance of the cancer coming back. It includes 103 adults with low-risk HPV-related oropharyngeal cancer. The goal is to see if a smaller radiation field is safe a…

This study tests whether using MRI scans to plan radiation therapy can lower the dose and reduce severe swallowing problems in people with HPV-positive throat cancer. About 90 adults with early-stage cancer will receive standard or MRI-adjusted radiation. The goal is to keep canc…

This study looks at whether a lower dose of radiation can safely control HPV-positive throat cancer in people who have never smoked or smoked very little. About 75 participants will be followed for up to 5 years to see if the cancer stays away and how their quality of life is. Th…

This study tests a new program designed to help head and neck cancer patients who feel depressed. The goal is to see if the program is practical and liked by patients, and if it can improve their mood and help them follow through with swallowing exercises and dental care. About 1…

This study screens 1500 adults for oral HPV infection and related antibodies to identify those at higher risk for HPV-related throat cancer. Researchers follow participants over time to see which infections persist and what factors (like mouth bacteria or immune response) play a …